Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat

Peng, Dong; Qiao, Hanzi; Tan, Hong-Yu; Wang, Yi-Xue; Luo, Dan; Qiao, Liang; Cai, Yefeng; Zhang, Shijie; Wang, Qi; Guan, Li

doi:10.1007/s11011-022-00947-0

Cited by 14 publications

(3 citation statements)

References 66 publications

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“…Firstly, SIRT1 can inhibit the expression of inflammatory-related genes such as cytokines and factors related to inflammatory signaling pathways ( Kitada et al, 2016 ). In recent studies on vascular dementia treatment, ligustilide has been shown to activate the AMPK/SIRT1 signaling pathway, ameliorate pathological changes in the hippocampus cells of dementia rats, promote remyelination, suppress the expression of inflammatory factors, and alleviate cognitive impairment following cerebral hemorrhage ( Peng et al, 2022 ). Secondly, SIRT1 can regulate the production and release of inflammatory mediators, for example, by inhibiting the activation of NF-κB, thereby reducing the synthesis and release of inflammatory mediators ( Ren et al, 2019 ).…”

Section: Latest Advances In Research At the Cellular And Molecular Levelmentioning

confidence: 99%

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

Li,

Fang

et al. 2024

Front. Cell. Neurosci.

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General anesthesia, as a commonly used medical intervention, has been widely applied during surgical procedures to ensure rapid loss of consciousness and pain relief for patients. However, recent research suggests that general anesthesia may be associated with the occurrence of perioperative neurocognitive disorder (PND). PND is characterized by a decline in cognitive function after surgery, including impairments in attention, memory, learning, and executive functions. With the increasing trend of population aging, the burden of PND on patients and society’s health and economy is becoming more evident. Currently, the clinical consensus tends to believe that peripheral inflammation is involved in the pathogenesis of PND, providing strong support for further investigating the mechanisms and prevention of PND.

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Section: Latest Advances In Research At the Cellular And Molecular Levelmentioning

confidence: 99%

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

Li,

Fang

et al. 2024

Front. Cell. Neurosci.

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“…Angelica sinensis has medicinal effects on depression and cognitive disorders 4 , and its active ingredients include ligustilide (LIG) 5 , ferulic acid 6 , d -glucose 7 , etc. Among them, LIG is the main component of the volatile oil of angelica sinensis 8 , which has the properties of easy volatility and easy penetration of the blood-brain barrier, which allows LIG to be delivered to the brain through intranasal administration.…”

Section: Introductionmentioning

confidence: 99%

“…For example, LIG attenuates ischemic brain injury by inhibiting NLRP3 inflammasome activation and microglia focalization 11 and has potent neuroprotective effects against hemorrhagic stroke 12 . Also, studies have found that LIG can improve cognitive impairment in rats with vascular dementia 5 and mice with Alzheimer's disease 13 . In addition, the researchers found that Z-LIG, an isomer of LIG, exerts antidepressant-like effects in a rat model of depression 14 .…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics and computational chemistry approaches to explore the mechanism of the anti-depressive effect of ligustilide

Zhang

Teng

et al. 2023

Sci Rep

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Depression affects people with multiple adverse outcomes, and the side effects of antidepressants are troubling for depression sufferers. Aromatic drugs have been widely used to relieve symptoms of depression with fewer side effects. Ligustilide (LIG) is the main component of volatile oil in angelica sinensis, exhibiting an excellent anti-depressive effect. However, the mechanisms of the anti-depressive effect of LIG remain unclear. Therefore, this study aimed to explore the mechanisms of LIG exerting an anti-depressive effect. We obtained 12,969 depression-related genes and 204 LIG targets by a network pharmacology approach, which were intersected to get 150 LIG anti-depressive targets. Then, we identified core targets by MCODE, including MAPK3, EGF, MAPK14, CCND1, IL6, CASP3, IL2, MYC, TLR4, AKT1, ESR1, TP53, HIF1A, SRC, STAT3, AR, IL1B, and CREBBP. Functional enrichment analysis of core targets showed a significant association with PI3K/AKT and MAPK signaling pathways. Molecular docking showed strong affinities of LIG with AKT1, MAPK14, and ESR1. Finally, we validated the interactions between these proteins and LIG by molecular dynamics (MD) simulations. In conclusion, this study successfully predicted that LIG exerted an anti-depressive effect through multiple targets, including AKT1, MAPK14, and ESR1, and the pathways of PI3K/AKT and MAPK. The study provides a new strategy to explore the molecular mechanisms of LIG in treating depression.

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Exploring the therapeutic implications of natural compounds modulating apoptosis in vascular dementia

Zhong,

Wang,

Zhang

et al. 2024

Phytotherapy Research

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Vascular dementia (VaD) is a prevalent form of dementia stemming from cerebrovascular disease, manifesting in memory impairment and executive dysfunction, thereby imposing a substantial societal burden. Unfortunately, no drugs have been approved for the treatment of VaD due to its intricate pathogenesis, and the development of innovative and efficacious medications is urgently needed. Apoptosis, a programmed cell death process crucial for eliminating damaged or unwanted cells within an organism, assumes pivotal roles in embryonic development and tissue homeostasis maintenance. An increasing body of evidence indicates that apoptosis may significantly influence the onset and progression of VaD, and numerous natural compounds have demonstrated significant therapeutic potential. Here, we discuss the molecular mechanisms underlying apoptosis and its correlation with VaD. We also provide a crucial reference for developing innovative pharmaceuticals by systematically reviewing the latest research progress concerning the neuroprotective effects of natural compounds on VaD by regulating apoptosis. Further high‐quality clinical studies are imperative to firmly ascertain these natural compounds' clinical efficacy and safety profiles in the treatment of VaD.

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Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat

Cited by 14 publications

References 66 publications

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

Bioinformatics and computational chemistry approaches to explore the mechanism of the anti-depressive effect of ligustilide

Exploring the therapeutic implications of natural compounds modulating apoptosis in vascular dementia

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