Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model

Lee, Euijeong; Yun, Na-Ra; Jang, Young Pyo; Kim, Jinju

doi:10.1016/j.jep.2013.06.014

Cited by 73 publications

(44 citation statements)

References 46 publications

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“…It is easily found in China and has long been used as food and traditional medicine for at least 2000 y (Haw ). Lily bulb extracts are shown to strongly cure bronchitis and pneumonia (Lee and others ). The lily bulb not only contains nutritive material, such as protein, starch, glucomannan, and dietary fiber (Yamagishi ; Shin and others ), but also accumulates various bioactive compounds, including colchicine, saponin, and polysaccharides (Satou and others ).…”

Section: Introductionmentioning

confidence: 99%

Morphology and Physicochemical Properties of 3 Lilium Bulb Starches

Zhang

Li³

et al. 2015

Journal of Food Science

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Lilium (Liliaceae) is an important wild plant and is used as food and traditional medicine worldwide. One Lilium cultivar (Lilium lancifolium) and 2 wild types (Lilium leucanthum and Lilium rosthornii) that are commonly distributed in Western China were investigated to completely utilize Lilium resources. The morphology of the flowers, bulbs, and scales and soluble sugar, total starch and amylose contents was remarkably different among the 3 Lilium species. Starches from the 3 Lilium species presented different granule size and shape. The starch of L. lancifolium exhibited higher swelling power and solubility than that of L. leucanthum and L. rosthornii. The starches from the 3 Lilium bulbs presented similar X-ray diffraction patterns and Fourier transform infrared spectroscopy. Among the 3 Lilium species, L. lancifolium showed the lowest crystallinity and the largest proportion of ordered structures in granule external region. Gelatinization temperatures and retrogradation percentage were significantly lower, but gelatinization enthalpy was significantly higher in L. lancifolium than those in L. leucanthum and L. rosthornii. Pasting properties of starch were different among the 3 Lilium species. Starch from L. lancifolium showed the highest degree of amylopectin branching, followed by L. leucanthum and L. rosthornii. Starches from L. leucanthum and L. rosthornii showed higher resistance to porcine pancreatic α-amylase hydrolysis compared to that of L. lancifolium. These results indicated that 3 Lilium bulbs exhibited remarkable differences in morphological, crystal, thermal, pasting, and hydrolysis properties of starches.

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Section: Introductionmentioning

confidence: 99%

Morphology and Physicochemical Properties of 3 Lilium Bulb Starches

Zhang

Li³

et al. 2015

Journal of Food Science

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“…We also reported that Lilium lancifolium Thunb. root extract reduces lung inflammation and airspace enlargement in a CS-exposed mouse model [13]. Interestingly, GC treatment ameliorated the lung pathological changes in CS exposure models.…”

Section: Discussionmentioning

confidence: 90%

“…The total duration of exposure to CS was 1.5 hr per day. Pair-fed sham controls were subjected to air exposure instead of CS exposure under similar conditions [13,14]. Many gender difference researches for smoking-related lung disease demonstrated that the adverse effects of smoking in lung function may be greater in females than in males [15,16].…”

Section: Uplc-esi-ms Analysismentioning

confidence: 99%

Galla Chinensis Attenuates Cigarette Smoke‐associated Lung Injury by Inhibiting Recruitment of Inflammatory Cells into the Lung

Lee

Lim

et al. 2014

Basic Clin Pharma Tox

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Inflammation is a common feature in the pathogenesis of cigarette smoke (CS)-associated diseases. In this study, we investigated the effects of Galla Chinensis (GC) extract on pulmonary inflammatory responses in a CS-exposed mouse model. In vitro studies showed that GC extract reduced MCP-1 production in a dose-dependent manner. In addition, the recruitment of inflammatory cells into the lung was significantly inhibited in the bronchoalveolar lavage fluid (BALF) of the GC-treated mice after 3 weeks of daily CS exposure. GC treatment down-regulated TNF-a, IL-6 and MCP-1 mRNA expression levels in lung tissue. Finally, GC-treated mice showed less emphysematous change of alveolar compared to mice only exposed to CS. Our results show that GC extract reduces lung inflammation and emphysematous change by inhibiting the infiltration of inflammatory cells to the lung. These data indicate that GC extract is a therapeutic candidate for CS-induced lung injury.

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“…Moreover, MMP-12 in serum was down-regulated in L. lancifolium Thunb root water extract treated mice contrasted with CS-exposed mice. The water extract treated mice demonstrated a significant reduction in air space size compared to mice only exposed to CS [15].…”

Section: Pharmacological Studiesmentioning

confidence: 88%

Lilium lancifolium 百合 (Baihe, Tiger Lily)

Liu

2015

Dietary Chinese Herbs

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Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model

Cited by 73 publications

References 46 publications

Morphology and Physicochemical Properties of 3 Lilium Bulb Starches

Morphology and Physicochemical Properties of 3 Lilium Bulb Starches

Galla Chinensis Attenuates Cigarette Smoke‐associated Lung Injury by Inhibiting Recruitment of Inflammatory Cells into the Lung

Lilium lancifolium 百合 (Baihe, Tiger Lily)

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