Lim Kinase1 regulates seizure activity via modulating actin dynamics

Jiang, Qian; Tang, Guo Qing; Fu, Jie; Yang, Juan; Xu, Tao; Tan, Chong-Tin; Wang, You; Chen, Yangmei

doi:10.1016/j.neulet.2020.134936

“…However, MS in WAG/Rij rats decreased the most in thin spines. It is known that mushroom spines are more stable whereas thin spines are newly formed [27,28]. Therefore, our findings indicate that tactile stimulations not only modulate structural plasticity in the SoCx by decreasing spine numbers, but also by changing the ratio of new/mature spines.…”

Section: Discussionmentioning

confidence: 49%

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

İlbay

¹

,

Balikci

²

,

Köktürk

³

et al. 2021

Preprint

1

0

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Objective: The aim of our study is to examine the effects of neonatal tactile stimulatons on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy.Methods: In the present research, morphology and density of dendritic spines were analyzed in the somatosensory cortex (SoCx) of WAG/Rij rats (non stimulated control, tactile-stimulated and maternal separated rats) and healthy Wistar (non-epileptic) rats. To achieve this, a Golgi-Cox method was used.Results: Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at post natal day 150 in comparison to non-epileptic adult control Wistar rats (p<0,001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p<0,001).Conclusions: Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat’s brain and suggest a reduction in dendrite spine density is linked to absence seizure reduction.

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“…However, MS in WAG/Rij rats decreased the most in thin spines. It is known that mushroom spines are more stable whereas thin spines are newly formed [27,28]. Therefore, our ndings indicate that tactile stimulations not only modulate structural plasticity in the SoCx by decreasing spine numbers, but also by changing the ratio of new/mature spines.…”

Section: Resultsmentioning

confidence: 54%

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

İlbay

¹

,

Balikci

²

,

Köktürk

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background In previous studies, it has been shown that in early developmental period, the high level of tactile stimulations prevent absence epilepsy development and comorbid depression in Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rats with absence epilepsy. The aim of our study is to examine the effects of neonatal tactile stimulatons on the brain structures that previously defined as the focus of epilepsy in the rat brain with genetic absence epilepsy. Results In the present research, morphology and density of dendritic spines were analyzed in the somatosensory cortex (SoCx) in WAG/Rij rats with absence epilepsy, sensory experienced WAG/Rij rats (tactile-stimulated and maternal separated) and healthy Wistar (non-epileptic) rats. To achieve this, a Golgi-Cox method was used. Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at post natal day 150 in comparison to non-epileptic adult control Wistar rats (p < 0,001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p < 0,001). Conclusions Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat’s brain and suggest a reduction in dendrite spine density is linked to absence seizure reduction.

show abstract

“…MS in WAG/Rij rats decreased the most in thin spines. It is known that mushroom spines are more stable whereas thin spines are newly formed[27,28]. Therefore, our findings indicate that tactile stimulations not only modulate structural plasticity in the SoCx by decreasing spine numbers, but also by changing the ratio of new/mature spines.It is not surprising that tactile stimulations led to change spine density in the SoCx, where tactile sensation gets processed [17].Various data confirm the beneficial effects of enriched environment on synaptic plasticity in different animal models [29,30].…”

mentioning

confidence: 49%

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

İlbay

¹

,

Balikci

²

,

Köktürk

³

et al. 2021

Preprint

0

View full text Add to dashboard Cite

Objective: The aim of our study is to examine the effects of neonatal tactile stimulatons on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy.Methods: In the present research, morphology and density of dendritic spines were analyzed in the somatosensory cortex (SoCx) of WAG/Rij rats (non stimulated control, tactile-stimulated and maternal separated rats) and healthy Wistar (non-epileptic) rats. To achieve this, a Golgi-Cox method was used.Results: Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at post natal day 150 in comparison to non-epileptic adult control Wistar rats (p<0,001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p<0,001).Conclusions: Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat’s brain and suggest a reduction in dendrite spine density is linked to absence seizure reduction.

show abstract

Lim Kinase1 regulates seizure activity via modulating actin dynamics

Cited by 8 publications

References 34 publications

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

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