2018
DOI: 10.1002/14651858.cd012146.pub2
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Limb salvage for treating pathological fracture at diagnosis in children and adolescents with localized high grade osteosarcoma

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“…The last three have been related to an increased risk of suffering from osteosarcoma, but paradoxically they are the least studied syndromes/risk factors as causes of suffering from this bone cancer. On the other hand, hereditary retinoblastoma and Li-Fraumeni syndrome are the most studied diseases in relation to osteosarcomas [40][41][42][43][44][45][46][47][48][49][50][51][52].…”
Section: Genetic Instability In Osteosarcomamentioning
confidence: 99%
“…The last three have been related to an increased risk of suffering from osteosarcoma, but paradoxically they are the least studied syndromes/risk factors as causes of suffering from this bone cancer. On the other hand, hereditary retinoblastoma and Li-Fraumeni syndrome are the most studied diseases in relation to osteosarcomas [40][41][42][43][44][45][46][47][48][49][50][51][52].…”
Section: Genetic Instability In Osteosarcomamentioning
confidence: 99%