Limb segment vibration modulates spinal reflex excitability and muscle mRNA expression after spinal cord injury

Chang, Shuo Hsiu; Tseng, Shih Chiao; McHenry, Colleen L.; Littmann, Andrew E.; Suneja, Manish; Shields, Richard K.

doi:10.1016/j.clinph.2011.08.001

Cited by 16 publications

(29 citation statements)

References 54 publications

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“…We previously confirmed that the vibration intervention mimicked the mechanical input conditions of previous animal studies [19] and that it did not cause reflexive muscle contractions [30, 31]. We used a novel and sophisticated imaging approach to obtain outstanding imaging resolution for in vivo bone adaptations.…”

Section: Discussionsupporting

confidence: 60%

“…These parameters were selected to reflect the vibration conditions of recent studies that reported anabolic effects of vibration in the murine tibia [11, 13, 29]. We previously verified that vibration using these parameters does not increase background EMG activity [30] and downregulates monosynaptic reflex activity [31]. Reflex-mediated muscle contractions did not occur, eliminating muscle force as a potential confounding source of mechanical load to the bone.…”

Section: Methodsmentioning

confidence: 99%

“…To securely couple the limb segment to the vibrating surface, a compressive load of 10–15%of body weight was applied to the top of the knee via a full-contact pad. Technical details of the vibration system have been described elsewhere [19, 30, 31]…”

Section: Figmentioning

confidence: 99%

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Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

et al. 2015

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Summary This study examined the effect of a controlled dose of vibration upon bone density and architecture in people with spinal cord injury (who eventually develop severe osteoporosis). Very sensitive computed tomography (CT) imaging revealed no effect of vibration after 12 months, but other doses of vibration may still be useful to test. Introduction The purposes of this report were to determine the effect of a controlled dose of vibratory mechanical input upon individual trabecular bone regions in people with chronic spinal cord injury (SCI) and to examine the longitudinal bone architecture changes in both the acute and chronic state of SCI. Methods Participants with SCI received unilateral vibration of the constrained lower limb segment while sitting in a wheelchair (0.6g, 30 Hz, 20 min, three times weekly). The opposite limb served as a control. Bone mineral density (BMD) and trabecular micro-architecture were measured with high-resolution multi-detector CT. For comparison, one participant was studied from the acute (0.14 year) to the chronic state (2.7 years). Results Twelve months of vibration training did not yield adaptations of BMD or trabecular micro-architecture for the distal tibia or the distal femur. BMD and trabecular network length continued to decline at several distal femur sub-regions, contrary to previous reports suggesting a “steady state” of bone in chronic SCI. In the participant followed from acute to chronic SCI, BMD and architecture decline varied systematically across different anatomical segments of the tibia and femur. Conclusions This study supports that vibration training, using this study’s dose parameters, is not an effective antiosteoporosis intervention for people with chronic SCI. Using a high-spatial-resolution CT methodology and segmental analysis, we illustrate novel longitudinal changes in bone that occur after spinal cord injury.

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Section: Discussionsupporting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

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Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

et al. 2015

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“…Vibration is also being investigated as a method to reduce spasticity [2, 14], one of the most prevalent and bothersome secondary heath conditions of SCI [6]. Our previous work has characterized the acute neurophysiologic response to vibratory load after SCI [5]. We observed a long-lasting (>1 minute) enhancement of H-reflex post-activation depression after acute vibration of a constrained limb segment.…”

Section: Introductionmentioning

confidence: 84%

“…To quantify post-activation depression of H2, we calculated the depression ratio: 100* (HB – H2) / HB. Our previous work [5] indicated that during vibration in participants with SCI, H1 is unstable and is occasionally absent. This limits its suitability in calculations of H2 depression.…”

Section: Methodsmentioning

confidence: 99%

Vibration training after chronic spinal cord injury: Evidence for persistent segmental plasticity

Yen

McHenry

Petrie

et al. 2017

Neuroscience Letters

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H-reflex paired-pulse depression is gradually lost within the first year post-SCI, a process believed to reflect reorganization of segmental interneurons after the loss of normal descending (cortical) inhibition. This reorganization co-varies in time with the development of involuntary spasms and spasticity. The purpose of this study is to determine whether long-term vibration training may initiate the return of H-reflex paired-pulse depression in individuals with chronic, complete SCI. Five men with SCI received twice-weekly vibration training (30 Hz, 0.6 g) to one lower limb while seated in a wheelchair. The contra-lateral limb served as a within-subject control. Paired-pulse H-reflexes were obtained before, during, and after a session of vibration. Untrained limb H-reflex depression values were comparable to chronic SCI values from previous reports. In contrast, the trained limbs of all 5 participants showed depression values that were within the range of previously-reported Acute SCI and Non-SCI H-reflex depression. The average difference between limbs was 34.98% (p = 0.016). This evidence for the return of H-reflex depression suggests that even for people with long-standing SCI, plasticity persists in segmental reflex pathways. The spinal networks involved with the clinical manifestation of spasticity may thus retain adaptive plasticity after long-term SCI. The results of this study indicate that vibration training may hold promise as an anti-spasticity rehabilitation intervention.

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Supraspinal Responses and Spinal Reflexes

Ritzmann¹,

Mileva

2020

Manual of Vibration Exercise and Vibration Therapy

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Limb segment vibration modulates spinal reflex excitability and muscle mRNA expression after spinal cord injury

Cited by 16 publications

References 54 publications

Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

Vibration training after chronic spinal cord injury: Evidence for persistent segmental plasticity

Supraspinal Responses and Spinal Reflexes

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