Limbic Kindling in the Forebrain‐Bisected Photosensitive Baboon, Papio papio

Wada, Juhn A.; Mizoguchi, Tsuyomi

doi:10.1111/j.1528-1157.1984.tb04190.x

Cited by 42 publications

(1 citation statement)

References 30 publications

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“…Some lines of evidence exist to suggest that the generalized seizure induced either by ILS or by kindling stimulation may share not only electroclinical phenomenology but also a common neuronal mechanism. Thus, amygdaloid kindling in forebrain-bisected baboons fails to reach Stage 5 but results in a hemiconvulsive seizure state as verified by a spontaneously emitted seizure pattern (Wada and Mizoguchi, 1984). On the other hand, callosal bisection transforms the established pattern of bisymmetrical generalized convulsion (induced either by systemic administration of bemegride or kindling stimulation) in kindled baboons into hemiconvulsive seizure .…”

Section: Discussionmentioning

confidence: 95%

Reciprocal Inhibition between Seizures Induced by Intermittent Light Stimulation and Premotor Cortical Stimulation in Senegalese Baboons, Papio papio

Baba

Wada

1987

Epilepsia

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The temporal relationship between the degree of photosensitivity and the intensity of kindling stimulus response was examined in four Senegalese baboons, Papio papio, kindled at the premotor cortical area. When fully kindled, the intensity of photosensitivity diminished significantly in all the animals. With successive daily intermittent light stimulation, two animals showed partial recovery and the other two showed complete recovery to the prekindling level of photosensitivity. When premotor cortical kindling stimulation was subsequently reapplied, three-quarters of the animals failed to respond with kindled seizures and additional stimulations were necessary to reestablish kindled seizure. Two of these three animals also required increased stimulus intensity before the previously established generalized seizure threshold could be reinstated. The frontorolandic cortex is known as the most epileptogenic area in photosensitive Papio papio. In this species, spontaneous generalized convulsive seizures, intermittent light stimulation-induced seizures, and kindled generalized convulsive seizures are all known to share a common electroclinical phenomenology. The reciprocal inhibition observed in this study between generalized seizures induced by either intermittent light stimulation or by premotor cortical kindling stimulation further strengthens the possibility that they also share a common neuronal mechanism.

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Section: Discussionmentioning

confidence: 95%

Reciprocal Inhibition between Seizures Induced by Intermittent Light Stimulation and Premotor Cortical Stimulation in Senegalese Baboons, Papio papio

Baba

Wada

1987

Epilepsia

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Tourette syndrome attributed to frontal lobe dysfunction: Numerous etiologies involved

Gedye¹

1991

J. Clin. Psychol.

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The etiology of Tourette Syndrome (TS) according to prevailing views is unknown; there is evidence for both familial and sporadic cases. The author theorizes that abnormal discharges in the frontal lobes comprise the “final common dysfunction” that results in numerous phenomena labelled Tourette syndrome. Facial, vocal, and other motor symptoms of TS are catalogued in parallel with facial, vocal, and body movements that occur during frontal lobe seizures. The variety of etiologies that cause frontal lobe seizures–when applied to TS–can account more readily for heterogeneity of clinical presentations, the numerous “dual diagnosis” cases, and differential response to medication than can a single‐gene theory.

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Sexual dimorphism of the anterior commissure and massa intermedia of the human brain

Allen

Gorski

1991

J of Comparative Neurology

237

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Neuroanatomical sex differences were observed in the midsagittal area of both the anterior commissure and the massa intermedia on analysis of postmortem tissue from 100 age-matched male and female individuals. The anterior commissure, a fiber tract whose axons in primates primarily connect the two temporal lobes, was an average of 12%, or 1.17 mm2 larger in females than in males. The massa intermedia, a structure that crosses the third ventricle between the two thalami, was present in 78% of the females and 68% of the males. Among subjects with a massa intermedia, the structure was an average of 53.3% or 17.5 mm2 larger in females than in males. Inclusive of subjects with and without a massa intermedia, this structure was a mean of 76% or 16.93 mm2 greater in females than in males. These sex differences were present despite the fact that the brains of males were larger than those of females. Since a majority of subjects were adults, it is unknown when sexual differentiation occurred. Anatomical sex differences in structures that connect the two cerebral hemispheres may, in part, underlie functional sex differences in cognitive function and cerebral lateralization.

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Limbic Kindling in the Forebrain‐Bisected Photosensitive Baboon, Papio papio

Cited by 42 publications

References 30 publications

Reciprocal Inhibition between Seizures Induced by Intermittent Light Stimulation and Premotor Cortical Stimulation in Senegalese Baboons, Papio papio

Reciprocal Inhibition between Seizures Induced by Intermittent Light Stimulation and Premotor Cortical Stimulation in Senegalese Baboons, Papio papio

Tourette syndrome attributed to frontal lobe dysfunction: Numerous etiologies involved

Sexual dimorphism of the anterior commissure and massa intermedia of the human brain

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