Limfocyty Th17 w zakażeniach bakteryjnych

Szulc-Dąbrowska, Lidia; Gieryńska, Małgorzata; Depczyńska, Daria; Schollenberger, A.; Toka, Felix N.

doi:10.5604/17322693.1147868

Cited by 6 publications

(8 citation statements)

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“…Table 1. The influence of cytokines taking part in the UC pathogenesis on the development of the immune response [5,[7][8][9][10][11][12][13][14][15][16]. The altered balance of anti-inflammatory and pro-inflammatory cytokines (mainly towards the secretion of pro-inflammatory cytokines) may lead to the development of an excessive immune response, which is associated with further activation and infiltration of immune cells, increased cell apoptosis, and loss of intestinal barrier integrity [15].…”

Section: Introductionmentioning

confidence: 99%

The Role of Innate and Adaptive Immune Cells in the Pathogenesis and Development of the Inflammatory Response in Ulcerative Colitis

Kałużna

Olczyk

Komosińska-Vassev

2022

JCM

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Ulcerative colitis (UC) is a chronic inflammatory disease with an underlying excessive immune response directed against resident microbiota and/or dietary antigens. Both innate and adaptive immune cells play a crucial role in the pathogenesis of UC. In the case of innate immune response cells, neutrophils, dendritic cells, macrophages have a crucial impact on the development of the disease, as well as innate lymphoid cells, which have received a particular attention in recent years. On the other hand, mechanisms of the adaptive immune response involve cells such as: cytotoxic lymphocytes, regulatory lymphocytes Treg, or helper lymphocytes Th–Th2, Th9, Th17, Th22, among which significant discoveries about Th9 and Th17 lymphocytes have been made in recent years. Due to the presence of antibodies directed against resident microbiota or one’s own tissues, the influence of B lymphocytes on the development of UC is also highlighted. Additionally, the impact of cytokines on shaping the immune response as well as sustaining inflammation seems to be crucial. This review briefly describes the current state of knowledge about the involvement of the innate and adaptive immune systems in the pathogenesis of UC. The review is based on personal selection of literature that were retrieved by a selective search in PubMed using the terms “ulcerative colitis” and “pathogenesis of ulcerative colitis”. It included systematic reviews, meta-analyses and clinical trials. Our knowledge of the involvement of the immune system in the pathophysiology of IBD has advanced rapidly over the last two decades, leading to the development of several immune-targeted treatments with a biological source, known as biologic agents.

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Section: Introductionmentioning

confidence: 99%

The Role of Innate and Adaptive Immune Cells in the Pathogenesis and Development of the Inflammatory Response in Ulcerative Colitis

Kałużna

Olczyk

Komosińska-Vassev

2022

JCM

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“…IL-17 can be produced by Th17 cells, as well as some other immune cells such as mast cells, neutrophils and macros. It is associated with autoimmune disease, infection disease and is treated as a therapeutic target in recent years [ 11 – 13 ]. However, data’s come from different research groups were controversial about the expression of IL-17 between AA patients and normal controls [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Reduced IL-33 plasma levels in aplastic anemia

Sun

Che

et al. 2015

Cancer Cell Int

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BackgroundIn this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA).MethodsPlasma IL-33, IL-17 and sST2 levels were measured in patients with active AA (n = 31), AA in remission (n = 29) and in healthy subjects (n = 30), using enzyme linked immunosorbent assays (ELISAs).ResultsThe results showed that sST2 and IL-17 levels were significantly elevated in patients with active AA when compared to control subjects, but IL-33 levels were significantly lower in AA patients, which resulted in elevated sST2/IL-33 ratios in patients with active disease. During remission stages, the levels of these cytokines were comparable to those of healthy controls.ConclusionsThe elevated levels of sST2/IL-33 in the plasma during active stages of the disease suggest a possible role in the pathogenesis and course of AA.

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“…In host defensive responses, IL-17A is mostly beneficial against infections caused by extracellular bacteria, intracellular bacteria, and fungi [31,32,45]. Mice injected with IL-17A-neutralizing antibodies have significantly (1 μg/100 μl) was injected into the tail veins of BALB/c mice at 24 h before S. agalactiae (1 × 10 8 CFU) infection or 6 h after infection.…”

Section: Discussionmentioning

confidence: 99%

“…Th17 cells are a relatively newly discovered subpopulation of helper CD4 + T lymphocytes that have a unique transcriptional profile (STAT3, RORγ and RORα) and cytokine production pattern (IL-17 family), as well as specific cytokine requirements for their differentiation (TGF-β and IL-6) [28,29]. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that Th17 cells can recruit leukocytes (mainly neutrophils) to infection sites by producing the signature cytokine IL-17A, which plays critical roles in protecting the host from pathogenic bacterial infections [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

IL-17A Secreted by Th17 Cells Is Essential for the Host against Streptococcus agalactiae Infections

Chen

Yang

et al. 2021

J. Microbiol. Biotechnol.

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Streptococcus agalactiae is an important bacterial pathogen and causative agent of diseases including neonatal sepsis and meningitis, as well as infections in healthy adults and pregnant women. Although antibiotic treatments effectively relieve symptoms, the emergence and transmission of multidrug-resistant strains indicate the need for an effective immunotherapy. Effector T helper (Th) 17 cells are a relatively newly discovered subpopulation of helper CD4 + T lymphocytes, and which, by expressing interleukin (IL)-17A, play crucial roles in host defenses against a variety of pathogens, including bacteria and viruses. However, whether S. agalactiae infection can induce the differentiation of CD4 + T cells into Th17 cells, and whether IL-17A can play an effective role against S. agalactiae infections, are still unclear. In this study, we analyzed the responses of CD4 + T cells and their defensive effects after S. agalactiae infection. The results showed that S. agalactiae infection induces not only the formation of Th1 cells expressing interferon (IFN)-γ, but also the differentiation of mouse splenic CD4 + T cells into Th17 cells, which highly express IL-17A. In addition, the bacterial load of S. agalactiae was significantly increased and decreased in organs as determined by antibody neutralization and IL-17A addition experiments, respectively. The results confirmed that IL-17A is required by the host to defend against S. agalactiae and that it plays an important role in effectively eliminating S. agalactiae . Our findings therefore prompt us to adopt effective methods to regulate the expression of IL-17A as a potent strategy for the prevention and treatment of S. agalactiae infection.

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Limfocyty Th17 w zakażeniach bakteryjnych

Cited by 6 publications

References 0 publications

The Role of Innate and Adaptive Immune Cells in the Pathogenesis and Development of the Inflammatory Response in Ulcerative Colitis

The Role of Innate and Adaptive Immune Cells in the Pathogenesis and Development of the Inflammatory Response in Ulcerative Colitis

Reduced IL-33 plasma levels in aplastic anemia

IL-17A Secreted by Th17 Cells Is Essential for the Host against Streptococcus agalactiae Infections

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