Limitations in the Diagnosis of Childhood Teratoid Lesions on Fine Needle Aspiration Cytology

Sharma, Sonal; Mishra, Kiran

doi:10.1159/000324999

Cited by 6 publications

(11 citation statements)

References 15 publications

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“…Majority of teratomas in infancy and childhood are benign as observed in study done by Sharmal and Mishra. [7] This is in concordance to our case.…”

Section: Various Clinical Differential Diagnosis In Neck Swellings In Infants Include Lymphangiomas or Cystic Hygromassupporting

confidence: 93%

“…It was suggested that aspiration from multiple sites is necessary to overcome these problems. [7] Chao et al also experienced similar problems in the diagnosis of immature teratomas and mixed germ cell tumors by cytology. [8] On viewing FNAC slides retrospectively, we noticed that our needle went into an area of mature glial-tissue consisting predominantly of oligodendrocytes.…”

Section: Discussionmentioning

confidence: 90%

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Congenital Cervical Teratoma Mimicking as Neuroblastoma on Cytology: A Diagnostic Pitfall

Chhabra

Dhingra

Baliyan

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Cervical teratomas are very rare tumors, accounting for approximately 3%-5% of all pediatric teratomas with predominance in females. Most common site of cervical teratoma is sacrococcygeal region and occurrence in cervical region is a rare presentation. We present a case of cervical teratoma in a 4-month-old male infant presenting as neck mass mimicking as neuroblastoma with differentiation on fine-needle aspiration. The final diagnosis of mature teratoma was made on histopathological examination.

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“…Majority of teratomas in infancy and childhood are benign as observed in study done by Sharmal and Mishra. [7] This is in concordance to our case.…”

Section: Various Clinical Differential Diagnosis In Neck Swellings In Infants Include Lymphangiomas or Cystic Hygromassupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Congenital Cervical Teratoma Mimicking as Neuroblastoma on Cytology: A Diagnostic Pitfall

Chhabra

Dhingra

Baliyan

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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“…8 Fine needle aspiration cytology features of FIF have been discussed only in very few scenarios where it mimicked teratoma and teratoid Wilms tumor cytologically owing to the presence of a heterogeneous cell population. 11 In our case, too, the presence of both spindle cells and small round cells prompted us to consider differential diagnoses of teratoma and neuroblastoma. This is highlighted as a pitfall in the diagnosis of teratoid lesions of childhood on FNA cytology, where supplementary radiologic investigations are instrumental in arriving at the correct diagnosis.…”

Section: Discussionmentioning

confidence: 71%

“…This is highlighted as a pitfall in the diagnosis of teratoid lesions of childhood on FNA cytology, where supplementary radiologic investigations are instrumental in arriving at the correct diagnosis. 11 …”

Section: Discussionmentioning

confidence: 99%

Fetus in Fetu as a suprarenal mass in a neonate a rare and perplexing entity

Ravishankar¹,

CS²,

Pazhayattil³

2022

Autops Case Rep

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Fetus in fetu (FIF) is a rare entity in which a malformed vertebrate fetus is incorporated within its twin. This entity should be differentiated from a teratoma, which has more malignant potential. We describe a neonate with a heterogeneous calcified suprarenal mass. The aspiration cytology revealed a heterogeneous cell population with spindle cells and small round blue cells. Operative and histopathologic examination showed features consistent with a fetus in fetu. This case report describes a rare entity and discusses its clinical presentation, cytological features on fine-needle aspiration, and the difficulties posed in its differentiation from a teratoma.

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“…3 The most common elements of mediastinal teratomas are squamous epithelium, adnexa, respiratory epithelium, glandular tissue, cartilage, and adipose tissue. 2,3,9,20 If the lesion is cystic, a paucicellular smear may be aspirated. The admixture of a heterogeneous population of cells is a helpful diagnostic clue.…”

Section: Discussionmentioning

confidence: 99%

Cytopathologic diagnosis of extragonadal germ cell tumors: A 10‐year institutional review

Geisler,

Marshall,

Bastacky

et al. 2023

Cancer Cytopathology

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BackgroundThe occurrence of extragonadal germ cell tumors (EGGCTs), either as primary tumors or metastatic disease, is rare. Forms of cytologic sampling, including fluid analysis, fine‐needle aspiration, and/or small‐core needle biopsy, have been shown to be reliable methods for the diagnosis of germ cell tumors. This study aims to investigate the utility of cytopathologic techniques in the diagnosis of EGGCTs at the authors’ institution.MethodsThe laboratory information system was queried over a period of 10 years (2012–2022) to identify all cytology cases diagnosed on fluid cytology, FNA, and/or small‐core biopsy as germ cell tumors in extragonadal locations. Patient demographics, tumor location, serum tumor marker levels, cytopathologic diagnosis, and follow‐up surgical resection data were reviewed and correlated.ResultsA total of 35 cases from 32 patients (all males) were identified. Thirty specimens contained satisfactory material for diagnosis (86%) and five were less than optimal for evaluation (14%). Despite this, all cases had clinically useful cytopathologic diagnoses. A total of 19 cytology cases (16 patients) had follow‐up resection specimens available. Of these, 11 patients underwent preoperative chemotherapy. Nine patients showed no evidence of residual tumor and two showed histologic concordance. Of the five patients who did not have preoperative chemotherapy, all showed concordant histologic diagnoses.ConclusionsCytology can provide a reliable, accurate method for diagnosing EGGCTs. The practice of preoperative (neoadjuvant) chemotherapy places an extreme importance on the initial cytopathologic diagnosis because the majority of patients with follow‐up resection in this series showed no residual tumor.

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Limitations in the Diagnosis of Childhood Teratoid Lesions on Fine Needle Aspiration Cytology

Cited by 6 publications

References 15 publications

Congenital Cervical Teratoma Mimicking as Neuroblastoma on Cytology: A Diagnostic Pitfall

Congenital Cervical Teratoma Mimicking as Neuroblastoma on Cytology: A Diagnostic Pitfall

Fetus in Fetu as a suprarenal mass in a neonate a rare and perplexing entity

Cytopathologic diagnosis of extragonadal germ cell tumors: A 10‐year institutional review

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