Limitations of Biomarkers Serum Levels During Pulmonary Vein Isolation

Comparative Determination and Monitoring of Biomarkers of Necrosis and Myocardial Remodeling between Radiofrequency Ablation and Cryoablation

“…In a recent publication, Wojcik et al propose that CK-MB is not a good biomarker for quantitative determination of myocardial injury produced by radiofrequency energy, because of its instability at temperatures above 40 • C. The authors explain that only cardiac troponins reflect myocardial injury and should be used for comparison between both ablation procedures. 15 In this sense, the present study shows higher TnI levels after cryoablation procedure versus RF. This finding supports our hypothesis of different lesion formation between cryoablation and RF.…”

Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation

“…As several markers have been proven to be useful for diagnosis and evaluation of size of myocardial injury after acute ischemic episode, many authors tried to implement different biomarkers to evaluate and quantify the size of effective ablation lesions [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. On one hand, previous studies have univocally shown humoral biomarkers for myocardial injury to be elevated after radiofrequency (RF) ablation, depending on the amount of energy delivered and the site of ablation [5].…”

“…On one hand, previous studies have univocally shown humoral biomarkers for myocardial injury to be elevated after radiofrequency (RF) ablation, depending on the amount of energy delivered and the site of ablation [5]. On the other hand, contrasting data exist about myocardial injury biomarker trend after cryoablation procedures [6][7][8][9]. Furthermore, to date, no data have been available on these biomarkers after laser balloon ablation or after RF catheter ablation with the assistance of contact-force-sensing technology.…”

A Novel Marker to Predict Early Recurrence After Atrial Fibrillation Ablation: The Ablation Effectiveness Quotient

“…Cardiac troponin T (cTnT) is released when myocardial cell death occurs and the level detectable in the bloodstream correlates with the mass of necrotic cardiac myocytes . Serum cTnT is the most reliable marker of myocardial damage after AF ablation . The high‐sensitivity assay (HScTnT) is an order of magnitude more sensitive than previously available commercial assays .…”