Limitations of FDG-PET and FDG-PET With Computed Tomography for Detecting Synchronous Cancer in Pharyngeal Cancer

Suzuki, Hitomi; Hasegawa, Yasuhisa; Terada, Akihiro; Ogawa, Tetsuya; Hyodo, Ikuo; Suzuki, Masahiro; Nakashima, Tsutomu; Tamaki, Tsuneo; Nishio, Masami

doi:10.1001/archotol.134.11.1191

Cited by 19 publications

(11 citation statements)

References 20 publications

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“…26,27 However, PET-CT adds to significant radiation exposure, which is 5-10 times greater than a normal background radiation. 25 The survey subjects in our study were in agreement with the fact that PET-CT was better in identifying the tumor location, size, and activity. SPECT traces a single radiation and not a simultaneous double one, unlike PET.…”

supporting

confidence: 84%

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Evaluation of knowledge, attitude, and practice regarding positron emission tomography scan: A cross-sectional survey

Nagaraj¹,

Santosh²,

James³

et al. 2015

JMRPS

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Background and Objectives: Positron emission tomography (PET) scan is a radionuclide imaging technique with implications in diagnostic and therapeutic oncology. Due to the complexity in the technique and cost factor, this technique has not been popular among the general and specialty dental practitioners. This survey study utilizes the Likert item to evaluate the intensity of response toward the technical and practical aspects of PET scan in dentistry. Materials and Methods: A representative population of 500 respondents was chosen by randomization. These respondents were either postgraduates or staff of various dental specialties. A close-ended questionnaire was provided inclusive of the Likert items. Simple arithmetic percentages were calculated to evaluate the knowledge and practice. One-way ANOVA test was done to evaluate the Likert items and regression analysis was done to find a correlation between the questions asked in attitude. Result: Statistically significant values (P = 0.0010) were obtained while evaluating the Likert items. Linear regression analysis showed a strong correlation between the questions asked in attitude. Conclusion:The overall impression of the survey revealed that the knowledge of the respondents was above optimum. However, the responses in attitude revealed a lack of practical knowledge and inhibitions pertaining to prescribe PET scan in dentistry.

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supporting

confidence: 84%

“…Hence, claustrophobia is one of the main disadvantages of PET scan. 25 This practical issue was well understood by our respondents. Tumor localization is one of the greatest challenges in any diagnostic modality.…”

mentioning

confidence: 84%

Evaluation of knowledge, attitude, and practice regarding positron emission tomography scan: A cross-sectional survey

Nagaraj¹,

Santosh²,

James³

et al. 2015

JMRPS

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“…42 There are also reports on finding synchronous double cancers. 43,44 Additionally, there are reports that PET/CT has high diagnostic performance even in diagnosing postoperative recurrence. 45,46 Other reports described that treatment strategies were changed by a PET diagnosis, and some cases avoided surgery after detecting a distant metastasis by PET.…”

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confidence: 99%

F-18 FDG PET/CT Contributes to More Accurate Detection of Lymph Nodal Metastasis From Actively Proliferating Esophageal Squamous Cell Carcinoma

Tanabe

Naomoto

Shirakawa

et al. 2011

Clinical Nuclear Medicine

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“…A significant limitation of 18 F-FDG PET imaging is the accumulation in inflamed tissues, leading to false-positive results (15). D-18 F-FMT proved to have no accumulation in turpentine-induced inflammatory tissue in a mouse model, whereas 18 F-FDG displayed significant uptake and retention (11).…”

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confidence: 99%

First Clinical Results of (d)-¹⁸F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in Patients with Non–Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma

et al. 2014

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and 9 MRI Stadelhofen, Zurich, Switzerland (D)-18 F-fluoromethyltyrosine (D-18 F-FMT), or BAY 86-9596, is a novel 18 F-labeled tyrosine derivative rapidly transported by the L-amino acid transporter (LAT-1), with a faster blood pool clearance than the corresponding L-isomer. The aim of this study was to demonstrate the feasibility of tumor detection in patients with non-small cell lung cancer (NSCLC) or head and neck squamous cell cancer (HNSCC) compared with inflammatory and physiologic tissues in direct comparison to 18 F-FDG. Methods: 18 patients with biopsyproven NSCLC (n 5 10) or HNSCC (n 5 8) were included in this Institutional Review Board-approved, prospective multicenter study. All patients underwent 18 F-FDG PET/CT scans within 21 d before D-18 F-FMT PET/CT. For all patients, safety and outcome data were assessed. Results: No adverse reactions were observed related to D-18 F-FMT. Fifty-two lesions were 18 F-FDG-positive, and 42 of those were malignant (34 histologically proven and 8 with clinical reference). Thirty-two of the 42 malignant lesions were also D-18 F-FMT-positive, and 10 lesions had no tracer uptake above the level of the blood pool. Overall there were 34 true-positive, 8 true-negative, 10 false-negative, and only 2 false-positive lesions for D-18 F-FMT, whereas 18 F-FDG was true-positive in 42 lesions, with 10 false-positive and only 2 false-negative, resulting in a lesion-based detection rate for D-18 F-FMT and 18 F-FDG of 77% and 95%, respectively, with an accuracy of 78% for both tracers. A high D-18 F-FMT tumor-to-blood pool ratio had a negative correlation with overall survival (P 5 0.050), whereas the 18 F-FDG tumor-to-blood pool ratio did not correlate with overall survival. Conclusion: D-18 F-FMT imaging in patients with NSCLC and HNSCC is safe and feasible. The presented preliminary results suggest a lower sensitivity but higher specificity for D-18 F-FMT over 18 F-FDG, since there is no D-18 F-FMT uptake in inflammation. This increased specificity may be particularly beneficial in areas with endemic granulomatous disease and may improve clinical management. Further clinical investigations are needed to determine its clinical value and relevance for the prediction of survival prognosis.

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Limitations of FDG-PET and FDG-PET With Computed Tomography for Detecting Synchronous Cancer in Pharyngeal Cancer

Cited by 19 publications

References 20 publications

Evaluation of knowledge, attitude, and practice regarding positron emission tomography scan: A cross-sectional survey

Evaluation of knowledge, attitude, and practice regarding positron emission tomography scan: A cross-sectional survey

F-18 FDG PET/CT Contributes to More Accurate Detection of Lymph Nodal Metastasis From Actively Proliferating Esophageal Squamous Cell Carcinoma

First Clinical Results of (d)-¹⁸F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in Patients with Non–Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma

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Limitations of FDG-PET and FDG-PET With Computed Tomography for Detecting Synchronous Cancer in Pharyngeal Cancer

Cited by 19 publications

References 20 publications

Evaluation of knowledge, attitude, and practice regarding positron emission tomography scan: A cross-sectional survey

Evaluation of knowledge, attitude, and practice regarding positron emission tomography scan: A cross-sectional survey

F-18 FDG PET/CT Contributes to More Accurate Detection of Lymph Nodal Metastasis From Actively Proliferating Esophageal Squamous Cell Carcinoma

First Clinical Results of (d)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in Patients with Non–Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma

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Product

Resources

About

First Clinical Results of (d)-¹⁸F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in Patients with Non–Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma