Limited Access to a Dietary Fat Option Affects Ingestive Behavior But Not Body Composition in Male Rats

Corwin, Rebecca L.; Wojnicki, F.H.E.; Fisher, Jennifer O.; Dimitriou, Steven G.; Rice, Harry B.; Young, M.

doi:10.1016/s0031-9384(98)00201-7

Cited by 165 publications

(213 citation statements)

References 39 publications

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“…The large intakes of the 18% and 32% fat emulsions may have been close to the maximum capacity of the rats, thus eliminating the possibility of differential daily and intermittent intakes. This is in contrast to prior studies using a similar rat model of binge-type eating in which rats on an intermittent schedule of access consumed significantly more solid 100% vegetable shortening ("binge") during their brief access period than did rats given daily brief access to the shortening (Corwin, 2004;Corwin et al, 1998;Davis, et al, 2007;Dimitriou et al, 2000;Thomas et al, 2002). The large intakes of the Intermittent groups in the present study would typically be perceived as binge-type eating if not for the concurrently elevated intake in the Daily groups.…”

Section: Pre-drug Solid Fat Emulsion and Chow Intakecontrasting

confidence: 92%

“…Average 1-hr gram intakes for all groups (∼7-10 g) were greater than intakes of 100% shortening reported in previous studies (∼5 g in Intermittent access groups) using similar protocols with male Sprague Dawley rats. In contrast, only the energy intake of the I-56% group (∼40 kcal) approached energy intakes reported in previous studies of 100% shortening in Intermittent access groups (∼45-50 kcal) (Corwin, 2004;Corwin, et al, 1998). The higher gram intakes, therefore, are at least partially accounted for by the reduced energy density of the solid fat emulsions.…”

Section: Pre-drug Solid Fat Emulsion and Chow Intakecontrasting

confidence: 54%

“…Rats on the Intermittent schedule of access were provided 1-hr of availability to their assigned solid fat emulsion on Mondays, Wednesdays, and Fridays only (I-18%, I-32%, and I-56%, N=10 each). These schedules were chosen based upon studies in which intermittent access induced binge-type consumption of 100% solid vegetable shortening (Corwin, 2004;Corwin, et al, 1998;Dimitriou, et al, 2000;Thomas, et al, 2002;Wojnicki et al, 2006). Rats were then placed on their assigned access schedules for a period of five weeks to establish a baseline before drug dose-effect curves were determined.…”

Section: Methodsmentioning

confidence: 99%

“…Rats were then placed on their assigned access schedules for a period of five weeks to establish a baseline before drug dose-effect curves were determined. Previous research has shown bingetype behavior to develop and become stable within this time frame (Corwin, 2004;Corwin et al, 1998;Dimitriou, et al, 2000;Thomas, et al, 2002). Chow consumption was monitored in addition to the grams of emulsion consumed during the 1-hr period of availability.…”

Section: Methodsmentioning

confidence: 99%

“…A behavioral model of binge-type eating in rats has been developed over the past few years in which an Intermittent (Monday, Wednesday, Friday or every third day) schedule of access to 100% vegetable shortening provided during a brief (1-2 hr) period of availability promotes excessive intakes relative to a Daily schedule of access (Corwin, 2004;Corwin and BudaLevin, 2004;Corwin et al, 1998;Davis, et al, 2007;Dimitriou, et al 2000;Thomas, et al, 2002). It has also been shown that under an Intermittent schedule of access rats consume as much shortening during the brief period of availability as is consumed in a 24-hr period when rats have continuous shortening access (24-hr per day -7 days/week) (Dimitriou et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions

Rao

Wojnicki

Coupland

et al. 2008

Pharmacology Biochemistry and Behavior

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Previous work in rats has demonstrated that an Intermittent (Monday, Wednesday, Friday) schedule of access promotes binge-type consumption of 100% vegetable shortening during a 1-hour period of availability. The present study used novel shortening-derived stable solid emulsions of various fat concentrations. These emulsions were the consistency of pudding and did not demonstrate oil and water phase separation previously reported with oil-based liquid emulsions. Male Sprague-Dawley rats were grouped according to schedule of access (Daily or Intermittent) to one of three concentrations (18%, 32%, 56%) of solid fat emulsion. There were no significant Intermittent vs. Daily differences in amount consumed, due to high intakes in all groups. This indicated the acceptability of the emulsions. Baclofen (GABA-B agonist) and raclopride (D2-like antagonist) both significantly reduced emulsion intake in all Daily groups, but only in the 56% fat Intermittent group. Naltrexone (opioid antagonist), in contrast, significantly reduced 32% and 56% fat emulsion intake in the Intermittent, as well as the Daily groups. These results indicate that the fat intake reducing effects of GABA B activation and D2 blockade depend upon fat concentration and schedule of fat access, while the fat intake reducing effects of opioid blockade depend upon fat concentration but not schedule of access.

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Section: Pre-drug Solid Fat Emulsion and Chow Intakecontrasting

confidence: 92%

Section: Pre-drug Solid Fat Emulsion and Chow Intakecontrasting

confidence: 54%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions

Rao

Wojnicki

Coupland

et al. 2008

Pharmacology Biochemistry and Behavior

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Binge Eating in Rats with Limited Access to Vegetable Shortening

Corwin

Wojnicki

2006

CP Neuroscience

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In this protocol, binge-type eating is induced in non-food-deprived rats by providing limited access to an optional source of dietary fat: vegetable shortening. The protocol is simple and inexpensive, and the binge behavior is robust, reliable, and maintainable across extended periods of time. Two peptides that normally affect fat intake in rats have no effect on fat intake under limited-access conditions. However, recent results with a GABA(B) receptor agonist and with progressive-ratio responding suggest that the behavior induced by the limited-access binge protocol may share similarities with substance abuse. This protocol is designed to model the kind of excessive behavior that characterizes bingeing-related eating disorders and certain addictions.

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Effects of limited access to a fat option on food intake and body composition in female rats

Dimitriou

Rice

Corwin

2000

Int. J. Eat. Disord.

102

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Objective The present investigation sought to determine if limiting access to an optional fatty food would induce binge‐type behavior patterns in non–energy‐deprived female rats. Method Four groups of rats had continuous access to a commercial rodent diet throughout the 8‐week study. In addition: (1) the control group had no access to vegetable shortening; (2) the high limitation group had access to shortening for 2 hr for 3 days each week; (3) the low limitation group had access to shortening for 2 hr every day; and (4) the no limitation group had continuous access to shortening. Results As access to the shortening decreased, intake during the 2‐hr access period increased. Total energy intake and body weight did not differ among groups. Body fat was greatest in the rats that ate the most cumulative shortening. Discussion These results indicate that, even under non–energy‐deprived conditions, limiting access to a preferred fatty food can induce binge‐type behavior in female rats. © 2000 by John Wiley & Sons, Inc. Int J Eat Disord 28: 436–445, 2000.

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Limited Access to a Dietary Fat Option Affects Ingestive Behavior But Not Body Composition in Male Rats

Cited by 165 publications

References 39 publications

Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions

Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions

Binge Eating in Rats with Limited Access to Vegetable Shortening

Effects of limited access to a fat option on food intake and body composition in female rats

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