Limited Benefit of Marine Protein Hydrolysate on Physical Function and Strength in Older Adults: A Randomized Controlled Trial

Abstract

Age-related muscle wasting can compromise functional abilities of the elderly. Protein intake stimulates muscle protein synthesis; however, ageing muscle is more resistant to stimuli. This double-blinded, randomized, controlled trial is one of the first registered studies to evaluate the effects of a supplement of marine protein hydrolysate (MPH) on measures of physical function and strength. Eighty-six older adults received nutritional supplements containing 3 g of MPH or a placebo for up to 12 months. Short Physical Performance Battery (SPPB), grip strength and gait speed were measured, and dietary intake was registered at baseline, 6 months, and 12 months. No difference was found between the intervention and control groups in mean change in SPPB (independent sample t-test, p = 0.41) or regarding time trend in SPPB, grip strength, or gait speed (linear mixed model). The participants in our study were well functioning, causing a ceiling effect in SPPB. Further, they had sufficient protein intake and were physically active. Differences in physical function between those completing the intervention and the dropouts might also have created bias in the results. We recommend that future studies of MPH be carried out on a more frail or malnourished population.

Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations

“…Concerning fish proteins, Nygard et al [ 43 ] aimed to demonstrate the benefits of cod peptides in older adults (n = 86, mean age of 73 years old) who ingested 3 g for a year. Parameters such as short physical performance battery, grip strength, gait speed, and dietary intake were considered, but at the end of the study, authors reported no significant differences observed after the test item ingestion.…”

Marine Peptides: Structure, Bioactivities, and a New Hope for Therapeutic Application

“…Marine peptides are approved as a food ingredient in Norway. The peptide compounds are manufactured by hydrolysis of the Atlantic cod Gadus morhua fillet [ 30 ]. The tablets are produced by Flexipharma AS and based on the marine peptide compound 565952 P from Firmenich Bjørge Biomarin AS.…”

“…This is one of the first long-term studies of MPH and age-related changes in muscle health. Despite a limited benefit of marine protein hydrolysate on physical function and strength in older adults was delivered, the authors came to the conclusion that a daily intake of 3 g MPH for 6 to 12 months would prevent loss of physical performance, compared with a placebo [ 30 ].…”