Limited disease of extra-pulmonary small cell carcinoma

Müller, Arndt-Christian; Gani, Cihan; Weinmann, Martin; Mayer, Frank; Sipos, Bence; Bamberg, M.; Eckert, Franziska

doi:10.1007/s00066-011-0045-4

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…However, there are underlying confouding factors including non-random patient allocation and limited sample size. Moreover, the overall rate of intracranial failure is only 12% at 5-years which is comparable to other series on extra-pulmonary small cell carcinoma (EPSCC) (De Caluwé et al, 2017; Naidoo et al, 2013; Müller et al, 2012). However, these patients did not undergo serial brain imaging during their follow-up and therefore the failure rate should be interpreted with caution.…”

Section: Discussionsupporting

confidence: 72%

Small cell carcinoma of cervix: A population-based study evaluating standardized provincial treatment protocols

Roy

Bahl

2019

Gynecologic Oncology Reports

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ObjectivesTo describe the patient characteristics, patterns of treatment, and outcome of patients with small cell carcinoma of Cervix (SmCC) treated with radical radiotherapy from a provincial cancer registry database.MethodsOverall 25 patients with SmCC were treated with radical radiotherapy (with or without chemotherapy) from January 1, 1994 to December 31, 2013. Nineteen patients had pure SmCC while 6 had additional neuroendocrine component. Patients were treated with combined chemo-radiotherapy using multi-agent chemotherapy with pelvic or combined pelvic and para-aortic radiotherapy. All patients received brachytherapy. Use of prophylactic cranial irradiation was dependent on physician discretion. Survival was estimated using Kaplan-Meier method and compared using log-rank test.ResultsWe report a median overall survival of 53.8 months for our cohort. After a median follow-up of 54 months for surviving patients, the overall survival (OS) and progression free survival (PFS) at 5-years were 48% and 46.4% respectively. Patients with stage I-IIA disease had superior 5-year PFS (67.3% vs. 11.1%; p = .004) and 5-year OS (62.5% vs. 22.2%; p = .006). Patients with node-negative disease had a trend towards better 5-year PFS (55.7% vs. 19%; p = .07) and OS (61.1% vs. 14.3% at 5-years; p = .06) Distant metastasis was the predominant site of disease progression (n = 12; 48%).ConclusionDistant metastasis is the predominant pattern of failure for patients with SmCC treated with radical chemo-radiotherapy. With modern chemo-radiotherapy protocols we can expect a 5 year survival of around 50%. Early stage and node-negative status appear to be favorable prognostic factors with survival rates at 5-year over 60%.

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Section: Discussionsupporting

confidence: 72%

Small cell carcinoma of cervix: A population-based study evaluating standardized provincial treatment protocols

Roy

Bahl

2019

Gynecologic Oncology Reports

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“…Preoperative radiotherapy is applied in rectal cancer (Sauer et al, 2012), postoperative treatment in breast cancer (Darby et al). Yet, also rare tumor entities like sarcoma and small cell carcinoma are treated with radiotherapy (Eckert et al, 2010a,b; Muller et al, 2012). Despite modern radiation techniques and advanced multimodal treatments local failures and distant metastases often limit the prognosis, especially due to limited salvage treatments (Muller et al, 2011; Zhao et al, 2012).…”

Section: Radiotherapymentioning

confidence: 99%

Ionizing radiation, ion transports, and radioresistance of cancer cells

Huber¹,

Butz²,

Stegen³

et al. 2013

Front. Physiol.

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The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds the DNA repair capacity of the tumor cell. Ionizing radiation reportedly does not only act on the DNA in the nucleus but also on the plasma membrane. In particular, ionizing radiation-induced modifications of ion channels and transporters have been reported. Importantly, these altered transports seem to contribute to the survival of the irradiated tumor cells. The present review article summarizes our current knowledge on the underlying mechanisms and introduces strategies to radiosensitize tumor cells by targeting plasma membrane ion transports.

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“…However it has been suggested that EPSCC should be managed similarly to SCLC. Therefore, multimodal therapy has become standard for LD of EPSCC [16,17,18,19]. In EPSCC patients with ED, systemic chemotherapy is the major treatment modality.…”

Section: Discussionmentioning

confidence: 99%

Primary Intracranial Small Cell Carcinoma: A Case Report and Review of the Literature

et al. 2013

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Background: Extrapulmonary small cell carcinoma is a distinct clinicopathological entity accounting for only 2.5-4% of small cell carcinomas. Here we present a case of primary intracranial small cell carcinoma. Case Report: A 69-year-old woman with an isolated brain lesion presented with progressive headaches, confusion, nausea, and vomiting. A magnetic resonance imaging scan of the brain revealed a 4 × 3 × 5-cm solitary cystic tumor in the right frontoparietal lobe, accompanied by a midline shift. The mass was resected and pathologically proven to be a small cell carcinoma. The patient was given adjuvant radiotherapy but refused any chemotherapy. At the 12-month follow-up the patient was alive and well. Conclusion: Primary intracranial small cell carcinoma presenting as an isolated lesion is extremely rare. While there are no standard treatment guidelines for these patients, the authors believe multimodality treatment including tumorectomy and postoperative radiotherapy should be recommended.

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Limited disease of extra-pulmonary small cell carcinoma

Cited by 13 publications

References 27 publications

Small cell carcinoma of cervix: A population-based study evaluating standardized provincial treatment protocols

Small cell carcinoma of cervix: A population-based study evaluating standardized provincial treatment protocols

Ionizing radiation, ion transports, and radioresistance of cancer cells

Primary Intracranial Small Cell Carcinoma: A Case Report and Review of the Literature

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