Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil

Bessa, Marcia Carvalho; Rodart, Itatiana Ferreira; Menezes, Gisele Barreto Lopes; Carmo, Theomira Mauadie Azevedo; Athanazio, Daniel Abensur; Reis, Mitermayer Galvão dos

doi:10.1590/s1413-86702009000400004

Cited by 5 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In disagreement with the current study, and most other Egyptian studies, regarding the higher prevalence of HCV among older contacts, a Brazilian study concluded that the risk of transmission of HCV did not increase with long periods of living together and of sharing of personal items [31] . Furthermore, we note there is a highly significant association between HCVseropositivity and caringfor the index cases during acute bleeding attacks, similar with dental care by professional dentists.…”

contrasting

confidence: 99%

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Goweda¹,

Rady²

2016

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

BACKGROUND: Hepatitis C virus (HCV) is a major cause of chronic hepatitis and is considered as a worldwide problem. Egypt has the highest HCV prevalence in the world. The Centers for Disease Control and Prevention(CDC) recommend HCV screening for all adults at high risk of infection. AIM: To determine the prevalence of HCV seropositivity among household contacts of HCV positive patients and study their habits. METHODS: A cross sectional study was conducted in Beltag; a rural village affiliated to Nile Delta. Interviewed questionnaire was used including sociodemographic data and HCV risk factors information.All household contacts were assessed for HCV infection by testing for anti-HCV antibody using a commercial ELISA. RESULTS: 102ofHCV hepatitis patients and 360 of their household contacts were included in the study. The prevalence of HCV seropositivity among household contacts was 35%.78(61.9%) of seropositive contacts were over forty years old, 42(33.3%) received parenteral anti-schistosomal therapy, 72(57.1%) helped family HCV patients during bleeding episodes. Logistical regression showed that the most significant variable associated independently to HCV seropositivity in patients' contacts was helping HCV patients during bleeding episodes (OR = 7.262;, p = 0.000). CONCLUSION:This study approximates the findings of other studies which reported a high prevalence seropositivity among HCV patient's contacts. Help HCV patients during bleeding episodes is the most significant risk factor for intrafamilial HCV transmission.

show abstract

contrasting

confidence: 99%

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Goweda¹,

Rady²

2016

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

show abstract

“…In addition to family contact and sexual behaviour, the shared use of personal items such as razor blades, toothbrushes, nail clippers and manicure cutters might be important factors for the intra-familial transmission of HCV [12] [19]. This opinion did not agree with a Brazilian study, where the authors concluded that the risk of transmission of HCV did not increase with long periods of living together, sexual activity and sharing of personal items [38]. Comparison between sex partners and other family members residing with the same household, having an HCV carrier as a reference, showed that intrafamilial contact is an important factor in the transmission of HCV.…”

Section: Discussionmentioning

confidence: 92%

Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study

El-Bendary¹,

Esmat²,

Neamatallah³

et al. 2014

OJGas

View full text Add to dashboard Cite

Aim: Liver disease is a leading cause of morbidity and mortality among Egyptians. The major cause is infection with HCV, with 70 000 up to 140 000 newly reported cases annually. The objectives of this study were to determine the prevalence of anti-HCV antibodies among household contacts of HCV index cases and to identify the possible risk factors of transmission of HCV among Egyptian families. Material and Methods: The present external pilot study (double centre study) was performed on a convenient sample of 125 index cases and their 321 household family contacts recruited from Mansoura & Cairo University where 2 questionnaires were used to collect data from the index & their related contacts. The all were exposed to clinical examinations, routine laboratory testing & screening for the prevalence of Anti-HCV antibodies. Results: The prevalence of anti-HCV seropositivity among household contacts of index cases was found to be 13.7% which husbands of female index cases ranked first followed by wives of male index cases (36.36% versus 17.86% respectively, P < 0.0001) while sons & daughter followed later (6.84% & 4.94% respectively). When the distribution of household contacts by risky behaviour towards index cases was investigated, it was found that significant prevalence of anti-HCV antibodies positivity was detected between household contacts reporting their index cases having haematemsis &/or bleeding wound (P < 0.05), and household contacts giving IV injection to their index cases (P < 0.05) & M. El-Bendary et al. 229 household contacts visiting the same dentist as the index cases (P < 0.01) when compared to household contacts not exposed to the same risk factors. Conclusion: Transmission might occur during family contact and sexual behavior.

show abstract

“…from 6 clinics (NI) 50.0 – – 43.0 84.1 Silva et al, 2006 38 Pop. from 10 clinics (NI) – – – – – Bessa et al, 2009 39 Pop. from 1 clinic (0%) – – – – – Freitas et al, 2008 40 Sample, 5 clinics (NI) 48.0 13 83 40.9 a 80.4 Galperim et al, 2010 41 Pop.…”

Section: Resultsmentioning

confidence: 99%

Persistently high hepatitis C rates in haemodialysis patients in Brazil [a systematic review and meta-analysis]

Niquini

Mota

Bastos

et al. 2022

Sci Rep

View full text Add to dashboard Cite

We conducted a systematic review and meta-analysis of studies assessing HCV infection rates in haemodialysis patients in Brazil (Prospero CRD #42021275068). We included studies on patients under haemodialysis, comprising both convenience samples and exhaustive information from selected services. Patients underwent HCV serological testing with or without confirmation by HCV RNA PCR. Exclusion criteria were the following: absence of primary empirical information and studies without information on their respective settings, study year, accurate infection rates, or full specification of diagnostic tests. Studies with samples ≤ 30 and serial assessments with repeated information were also excluded. Reference databases included PubMed, LILACS, Scopus, and Web of Science for the period 1989–2019. A systematic review was carried out, followed by two independent meta-analyses: (i) studies with data on HCV prevalence and (ii) studies with a confirmatory PCR (i.e., active infection), respectively. A comprehensive set of different methods and procedures were used: forest plots and respective statistics, polynomial regression, meta-regression, subgroup influence, quality assessment, and trim-and-fill analysis. 29 studies and 11,290 individuals were assessed. The average time patients were in haemodialysis varied from 23.5 to 56.3 months. Prevalence of HCV infection was highly heterogeneous, with a pronounced decrease from 1992 to 2001, followed by a plateau and a slight decrease in recent years. The summary measure for HCV prevalence was 34% (95% CI 26–43%) for studies implemented before 2001. For studies implemented after 2001, the corresponding summary measure was 11% (95% CI 8–15%). Estimates for prevalence of active HCV infection were also highly heterogeneous. There was a marked decline from 1996 to 2001, followed by a plateau and a slight increase after 2010. The summary measure for active HCV infection was 19% (95% CI 15–25%) in studies carried out before 2001. For studies implemented after 2001, the corresponding summary measure was 9% (95% CI 6–13%). Heterogeneity was pervasive, but different analyses helped to identify its underlying sources. Besides the year each study was conducted, the findings differed markedly between geographic regions and were heavily influenced by the size of the studies and publication biases. Our systematic review and meta-analysis documented a substantial decline in HCV prevalence among Brazilian haemodialysis patients from 1992 to 2015. CKD should be targeted with specific interventions to prevent HCV infection, and if prevention fails, prompt diagnosis and treatment. Although the goal of HCV elimination by 2030 in Brazil remains elusive, it is necessary to adopt measures to achieve micro-elimination and to launch initiatives towards targeted interventions to curb the spread of HCV in people with CKD, among other high-risk groups. This is of particular concern in the context of a protracted COVID-19 pandemic and a major economic and political crisis.

show abstract

Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil

Cited by 5 publications

References 34 publications

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study

Persistently high hepatitis C rates in haemodialysis patients in Brazil [a systematic review and meta-analysis]

Contact Info

Product

Resources

About