A feedback-based multi-layered STBC (MLSTBC) system, which is adapted to cochannel interference, is proposed. This system can adjust its transmitter configuration so that the largest throughput for the given SINR is obtained, also, it can use joint beamforming and power control to minimize cochannel interference so that the throughput requirement is satisfied. We propose an iterative algorithm to realize joint beamforming and power control for the feedback-based MLSTBC system, and in this algorithm, we derive the required SINR and the corresponding transmitter configuration for attaining the throughput requirement. Some properties and simulation results are presented, they show that the proposed algorithm helps the feedback-based MLSTBC system increase the probability of the success in meeting the throughput requirement, also they show that the feedback-based MLSTBC system results in larger throughput than MLSTBC (with fixed transmitter configuration), STBC, and V-BLAST.