Limited preventive effect of prednisone on neuropsychiatric symptoms in murine systemic lupus erythematosus

Lu, Feilong; Lu, Hongyang; Xie, Minhao; Li, Shan; Zu, Yunyun; Zhou, Jia; Yu, Jie; Wang, Shuang; Ruan, Yuanyuan; Wen, Chengping; Xu, Zhenghao

doi:10.1007/s10787-019-00587-4

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…The effects of corticosteroid treatment on neuropsychiatric symptoms in NPSLE may be limited, if not deleterious. Lu and colleagues report only minimal efficacy in murine models [ 179 ], while Zhu and colleagues show that prednisone might disrupt rather than relieve metabolic changes in the frontal cortex and hypothalamus in lupus mice models [ 180 ]. Several studies report an association between type I diabetes (T1DM) and epilepsy.…”

Section: Systemic Autoimmune Diseases and Epilepsymentioning

confidence: 99%

Epilepsy, Immunity and Neuropsychiatric Disorders

Fortunato

Giugno

Sammarra

et al. 2023

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Several studies have focused on the emerging role of immunity and inflammation in a wide range of neurological disorders. Autoimmune diseases involving central nervous system share well defined clinical features including epileptic seizures and additional neuropsychiatric symptoms, like cognitive and psychiatric disturbances. The growing evidence about the role of immunity in the pathophysiologic mechanisms underlying these conditions lead to the concept of autoimmune epilepsy. This relatively-new term has been introduced to highlight the etiological and prognostic implications of immunity in epileptogenesis. In this review, we aim to discuss the role of autoimmunity in epileptogenesis and its clinical, neurophysiological, neuroimaging and therapeutic implications. Moreover, we wish to address the close relationship between immunity and additional symptoms, particularly cognitive and psychiatric features, which deeply impact clinical outcome in these patients. To assess these aspects, we have first analyzed Rasmussen’s encephalitis. Subsequently, we have covered autoimmune encephalitis, particularly those associated with autoantibodies against surface neuronal antigens, as these autoantibodies express a direct immune-mediated mechanism, different from those against intracellular antigens. Then, we have discussed about the connection between systemic immune disorders and neurological manifestations. This review aims to highlight the need to expand knowledge about the role of inflammation and autoimmunity in the pathophysiology of neurological disorders and the importance to early recognize these clinical entities. Indeed, early identification may result in faster recovery and a better prognosis.

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Section: Systemic Autoimmune Diseases and Epilepsymentioning

confidence: 99%