Limited Production Of Plant Derived Anticancer Drugs Vinblastine And Vincristine

Alam, Pravej; Sharaf-El-Din, M.N.

doi:10.1055/s-0036-1578706

Cited by 2 publications

(2 citation statements)

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“…Indeed, the anticancer drugs vinblastine and vincristine were derived from the Madagascan endemic Catharanthus roseus (Apocynaceae) [ 12 ]. Certainly, the market value of vincristine alone was estimated to be USD 15 million per kilogram, in the year 2016 [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

Rummun

Rondeau²,

Bourdon³

et al. 2020

Pharmaceuticals

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Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain unexplored. The scarcity of rigorous scientific data on the surviving Mascarene endemic taxa renders bioprospecting of this untapped resource of utmost importance. Thus, in view of valorizing the native resource, this study has as its objective to investigate the bioactivities of endemic leaf extracts. Herein, seven Mascarene endemic plants leaves were extracted and evaluated for their in vitro antioxidant properties and antiproliferative effects on a panel of cancer cell lines, using methyl thiazolyl diphenyl-tetrazolium bromide (MTT) and clonogenic cell survival assays. Flow cytometry and comet assay were used to investigate the cell cycle and DNA damaging effects, respectively. Bioassay guided-fractionation coupled with liquid chromatography mass spectrometry (MS), gas chromatography-MS, and nuclear magnetic resonance spectroscopic analysis were used to identify the bioactive compounds. Among the seven plants tested, Terminaliabentzoë was comparatively the most potent antioxidant extract, with significantly (p < 0.05) higher cytotoxic activities. T. bentzoë extract further selectively suppressed the growth of human hepatocellular carcinoma cells and significantly halted the cell cycle progression in the G0/G1 phase, decreased the cells’ replicative potential and induced significant DNA damage. In total, 10 phenolic compounds, including punicalagin and ellagic acid, were identified and likely contributed to the extract’s potent antioxidant and cytotoxic activities. These results established a promising basis for further in-depth investigations into the potential use of T. bentzoë as a supportive therapy in cancer management.

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Section: Introductionmentioning

confidence: 99%

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

Rummun

Rondeau²,

Bourdon³

et al. 2020

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Indeed, the anticancer drugs vinblastine and vincristine were derived from the Madagascan endemic Catharanthus roseus (Apocynaceae) [12]. Certainly, the market value of vincristine alone was estimated to be 15 million USD per kilogram, in the year 2016 [13].…”

Section: Introductionmentioning

confidence: 99%

<strong>Focus on Mascarenes Endemic Plants with Specific Phytochemical Composition, Potent Antioxidant and Antiproliferative Properties</strong>

Rummun¹,

Rondeau²,

Bourdon³

et al. 2020

Preprint

View full text Add to dashboard Cite

Tropical forests constitute prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remains unexplored. Herein, seven Mascarene endemic plants leaves were extracted and evaluated for their in vitro antioxidant properties and antiproliferative effects on a panel of cancer cell lines using MTT and clonogenic cell survival assay. Flow cytometry and comet assay were used to investigate the cell cycle and DNA damaging effects, respectively. Bioassay guided-fractionation coupled with LC-Mass spectrometry (MS), gas chromatography-MS, and nuclear magnetic resonance spectroscopy analysis were used to identify the bioactive compounds. Among the seven plants tested, Terminalia bentzoë was comparatively the most potent antioxidant extract with significantly (p < 0.05) higher cytotoxic activities. T. bentzoë extract further selectively suppressed the growth of human hepatocellular carcinoma cells and significantly halted the cell cycle progression in G0/G1 phase, decreased the cells replicative potential and induced significant DNA damage. Ten phenolic compounds including punicalagin and ellagic acid were identified and likely contributed to the extract potent antioxidant and cytotoxic activities. These results established a promising basis for further in-depth investigations on the potential use of T. bentzoë as supportive therapy in cancer management.

show abstract

Limited Production Of Plant Derived Anticancer Drugs Vinblastine And Vincristine

Cited by 2 publications

References 0 publications

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

<strong>Focus on Mascarenes Endemic Plants with Specific Phytochemical Composition, Potent Antioxidant and Antiproliferative Properties</strong>

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