Limited resection for non–small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds

Lee, Winnie; Daly, Benedict D.T.; DiPetrillo, Thomas A.; Morelli, Donna M.; Neuschatz, Andrew C.; Morr, Jody; Rivard, Mark J.

doi:10.1016/s0003-4975(02)04098-5

Cited by 120 publications

(62 citation statements)

References 16 publications

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“…This method has been widely applied in prostate, brain (11) and lung cancer treatment (12), and has been proven to be effective for the inhibition of cancer progression.…”

Section: A B C Dmentioning

confidence: 99%

Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs

et al. 2011

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Abstract. Brachytherapy is regarded as the most effective method in the treatment of metastatic spinal tumors since little damage is caused to surrounding healthy tissue. However, this method may cause radiation myelopathy if an overdose occurs. In the present study, we established a Banna mini-pig 125 I spinal cord implantation model to provide a tool for the study of how to reduce these types of side effects. Cell cycle alteration, apoptosis and necrosis of spinal cord neurons in the presence of various doses and durations of 125 I brachytherapy were also investigated. The pigs were randomly divided into four groups, A, B, C and D. In group A, four 125 I seeds (total radioactivity, 4.0 mCi) were implanted into the dura mater of the spinal canal at the level of T13. In groups B and C, eight 125 I sources (total radioactivity, 8.0 mCi) were inserted at the same location. Groups A and C were raised for up to 8 months and group B for only 2 months. Neurons from the swine spinal cord at the T13 level were collected and cell cycle analysis was performed. Apoptosis and necrosis were tested by a terminal deoxynucleotidyl transferase dUTP nick endlabeling (TUNEL) assay. The Banna mini-pig brachytherapy model was successfully established. Radiation myelopathy was closely associated with radiation dose and duration, more neurons were blocked in the G2 and S phases as dose and time increased, and an increase in apoptosis and necrosis was detected. Ratios of apoptosis and necrosis were reduced as lower doses and shorter durations of radiation were applied. Our results demonstrate that the Banna mini-pig is an ideal animal to study 125 I brachytherapy. Low-dose and short-term brachytherapy may effectively decrease apoptosis and necrosis in spinal cord cells in Banna mini-pigs.

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“…This method has been widely applied in prostate, brain (11) and lung cancer treatment (12), and has been proven to be effective for the inhibition of cancer progression.…”

Section: A B C Dmentioning

confidence: 99%

Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs

et al. 2011

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“…Whilst ocular side-effects are common, such as retinopathy, papilloedema and cataracts, there was rarity of associated secondary cancers [2]. These implants have also found a role in reducing the incidence of local recurrences and prolonging survival in non-small cell lung cancer [3]. From a brain tumour perspective, these implants have been used in the management of metastatic brain tumours since 1987 [4].…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation surrounding iodine-125 beads after treatment of a low grade glioma.

Devadass¹,

Woon²,

Kenwright³

2013

Cureus

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Permanent iodine-125 beads have been used in the treatment of low-and high-grade gliomas with good results. On computed tomography (CT) and magnetic resonance imaging (MRI), increased enhancement around these beads is common and is usually thought to represent radiation necrosis or disruption of the blood brain barrier. Further investigation of these areas of enhancement is warranted due to the rare possibility of malignant transformation occurring around these beads. Advances in radiological imaging, such as Fludeoxyglucose Positron Emission Tomography (FDG PET), have been useful in differentiating malignant transformation from benign entities. We present the first reported case of a 33-year-old lady with malignant transformation occurring around these beads approximately three years post-resection of a low-grade glioma.

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“…In patients with a previous history of lobectomy/pneumonectomy or poor pulmonary function, ''less'' surgery (ie, wedge resection or segmentectomy) has been used, and radioactive seeds have been added to the resection site to increase the chances of achieving local control. [7][8][9] Alternatively, extracranial SBRT is used instead of a surgical option. To our knowledge, no previous studies have compared these 2 therapeutic options (IOS implantation and SBRT).…”

Section: Discussionmentioning

confidence: 99%

“…Reported local control rates using intraoperative brachytherapy with wedge resection have been in the range of 90% to 98% and have produced local control rates equivalent to those produced with lobectomy. [7][8][9] To our knowledge, this is the first report comparing the 2 treatment modalities. The data suggest that both treatment modalities offer efficacy in terms of local control.…”

Section: Original Articlementioning

confidence: 91%

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Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer

Parashar¹,

Patel²,

Monni³

et al. 2010

Cancer

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BACKGROUND:The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachytherapy versus patients who received stereotactic body radiotherapy (SBRT) for single malignant lung nodules. METHODS: A retrospective chart review included 55 patients who were treated for single lung nodules, and 47 of those patients who had adequate information were chosen for the current analysis. Twentyfive patients with single malignant lung nodules received SBRT. Twenty-two patients underwent limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules. RESULTS: Univariate statistical analysis demonstrated a significance difference only for age in the 2 groups: The mean age in the radioactive seed group (66.6 years) was statistically significantly different from the mean of the age in the SBRT group (75.9 years; 2-sided P ¼ .04). No significant differences were observed between the 2 groups in terms of local control, distant metastasis, survival, or toxicity. CONCLUSIONS: The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and SBRT for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy. Cancer 2010;116:5047-53.

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Limited resection for non–small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds

Cited by 120 publications

References 16 publications

Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs

Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs

Malignant transformation surrounding iodine-125 beads after treatment of a low grade glioma.

Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer

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