Limited roles of Piezo mechanosensing channels in articular cartilage development and osteoarthritis progression

Young, Cameron J; Kobayashi, Tatsuya

doi:10.1016/j.joca.2023.01.576

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…Young et al . found that Piezo1 and Piezo2 conditional knockout ( Piezo1 Gdf5Cre ; Piezo2 Gdf5Cre ) cannot protect cartilage from injury 197 . However, a recent study by Laura et al found that inactivation of Piezo1 in chondrocytes ( Piezo1 Col2a1Cre ) alleviates cartilage degeneration and osteophyte formation following OA 198 .…”

Section: Implications Of Piezo1 In Musculoskeletal Disordersmentioning

confidence: 99%

The emerging role of Piezo1 in the musculoskeletal system and disease

Lei,

Wen,

Cao

et al. 2024

Theranostics

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Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating mechanical stimuli into biological signaling. Its involvement extends beyond physiological and pathological processes such as lymphatic vessel development, axon growth, vascular development, immunoregulation, and blood pressure regulation. The musculoskeletal system, responsible for structural support, movement, and homeostasis, has recently attracted attention regarding the significance of Piezo1. This review aims to provide a comprehensive summary of the current research on Piezo1 in the musculoskeletal system, highlighting its impact on bone formation, myogenesis, chondrogenesis, intervertebral disc homeostasis, tendon matrix cross-linking, and physical activity. Additionally, we explore the potential of targeting Piezo1 as a therapeutic approach for musculoskeletal disorders, including osteoporosis, muscle atrophy, intervertebral disc degeneration, and osteoarthritis.

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Section: Implications Of Piezo1 In Musculoskeletal Disordersmentioning

confidence: 99%

The emerging role of Piezo1 in the musculoskeletal system and disease

Lei,

Wen,

Cao

et al. 2024

Theranostics

View full text Add to dashboard Cite

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“…More precisely, the decrease in chondrocyte's stiffness resulted in increased cellular deformation in response to mechanical loading [126]. Interestingly, Young et al investigated the role of Piezo channels in OA mice demonstrating that the deletion of both genes does not impact normal joint development and has limited effects on OA progression [128].…”

Section: Pathological Changes In Osteoarthritismentioning

confidence: 99%

Biomechanics of Chondrocytes and Chondrons in Healthy Conditions and Osteoarthritis: A Review of the Mechanical Characterisations at the Microscale

et al. 2023

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Biomechanical studies are expanding across a variety of fields, from biomedicine to biomedical engineering. From the molecular to the system level, mechanical stimuli are crucial regulators of the development of organs and tissues, their growth and related processes such as remodelling, regeneration or disease. When dealing with cell mechanics, various experimental techniques have been developed to analyse the passive response of cells; however, cell variability and the extraction process, complex experimental procedures and different models and assumptions may affect the resulting mechanical properties. For these purposes, this review was aimed at collecting the available literature focused on experimental chondrocyte and chondron biomechanics with direct connection to their biochemical functions and activities, in order to point out important information regarding the planning of an experimental test or a comparison with the available results. In particular, this review highlighted (i) the most common experimental techniques used, (ii) the results and models adopted by different authors, (iii) a critical perspective on features that could affect the results and finally (iv) the quantification of structural and mechanical changes due to a degenerative pathology such as osteoarthritis.

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