Production of regions of antimatter in the early universe is predicted in many baryogenesis models. Small scale antimatter regions would annihilate during or soon after nucleosynthesis, affecting the abundances of the light elements. In this paper we study how the acceptable range in Ω b changes in the presence of antimatter regions, as compared to the standard big bang nucleosynthesis. It turns out that it is possible to produce at the same time both a low 4 He value (Yp < 0.240) and a low D/H value (D/H < 4 × 10 −5 ), but overproduction of 7 Li is unavoidable at large Ω b .