Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier <i>via</i> the microbiota-related ILC3–IL22–IL22R pathway

Wu, Wangling; Pan, Yingying; Zheng, Tianyan; Sun, Haoyi; Li, Xia; Zhu, Haiyan; Wang, Zheng; Zhou, Xin

doi:10.1039/d3fo04530g

Food Funct.

2024

DOI: 10.1039/d3fo04530g

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Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier via the microbiota-related ILC3–IL22–IL22R pathway

Wangling Wu,

Yingying Pan,

Tianyan Zheng

et al.

Abstract: High-fat diet (HFD)-induced dyslipidemia is frequently accompanied by gut microbiota dysbiosis and compromised gut barrier. Enhancing intestinal barrier function emerges as a potential therapeutic approach for dyslipidemia. The ILC3-IL22-IL-22R pathway,...

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Preventive potential of chitosan self‐assembled coconut residue dietary fiber in hyperlipidemia: Mechanistic insights into gut microbiota and short‐chain fatty acids

Li,

Tan,

Liu

et al. 2024

Journal of Food Science

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Hyperlipidemia is a metabolic disorder resulted from unhealthy dietary and lifestyle habits. Its pathogenesis is possibly linked to gut microbiota dysbiosis. This study investigates the preventive effects of chitosan self‐assembled coconut residue dietary fiber (CRFSC) on hyperlipidemia induced by a high‐fat diet (HFD) and gut microbiota. CRFSC resulted in a significant weight loss of 7.9% in HFD rats and had a preventive effect on all four lipid parameter abnormalities. HFD supplemented with oat group resulted in a weight loss of 3.8% in HFD rats and had no preventive effect on low‐density lipoprotein cholesterol (LDL‐C) abnormalities. Prevention was achieved not only through the modulation of gut microbiota composition and the increase of short‐chain fatty acids (SCFAs) levels, but also through the activation of superoxide dismutase enzyme and the inhibition of malondialdehyde accumulation, all of which are the factors leading to the controlling of lipid abnormalities and oxidative damage. The prevention of lipid parameters by chitosan self‐assembled coconut residue dietary fiber (CRFSC) may be attributed to its richness in chitosan and insoluble dietary fiber, as well as its ability to enrich beneficial bacteria such as Akkermansia, Roseburia, and Ruminococcus. Correlation analysis demonstrated that key bacterial species producing SCFAs, which are rich in the CRFSC diet, had a positive impact on controlling hyperlipidemia. Hence, consumption of a CRFSC diet could serve as an effective strategy for preventing and controlling the development of hyperlipidemia due to its potential ability to regulate gut microbiota and SCFAs.Practical ApplicationThis study showed that dietary fiber from coconut residue after chitosan self‐assembly had preventive effects on overweight, dyslipidemia, and oxidative damage in rats. In addition, CRFSC also increased the content of short‐chain fatty acids in the gut. And improve gut health by affecting gut microbiota. This finding suggests that CRFSC can be used as a dietary strategy to prevent hyperlipidemia and has practical significance in developing new healthy foods.

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Preventive potential of chitosan self‐assembled coconut residue dietary fiber in hyperlipidemia: Mechanistic insights into gut microbiota and short‐chain fatty acids

Li,

Tan,

Liu

et al. 2024

Journal of Food Science

View full text Add to dashboard Cite

show abstract

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Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier via the microbiota-related ILC3–IL22–IL22R pathway

Abstract: High-fat diet (HFD)-induced dyslipidemia is frequently accompanied by gut microbiota dysbiosis and compromised gut barrier. Enhancing intestinal barrier function emerges as a potential therapeutic approach for dyslipidemia. The ILC3-IL22-IL-22R pathway,...

Cited by 1 publication

References 54 publications

Preventive potential of chitosan self‐assembled coconut residue dietary fiber in hyperlipidemia: Mechanistic insights into gut microbiota and short‐chain fatty acids

Preventive potential of chitosan self‐assembled coconut residue dietary fiber in hyperlipidemia: Mechanistic insights into gut microbiota and short‐chain fatty acids

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