Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway

Mahmoud, Mona F.; Gamal, Samar; El-Fayoumi, Hassan M.

doi:10.1016/j.ejphar.2014.06.010

Cited by 60 publications

(43 citation statements)

References 49 publications

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“…The unbalanced solubility profile of the latter may explain the relatively low number of studies on their respective biological activities which are hampered by difficult isolation from natural sources and poor pharmacokinetics. Analgesic [45], anticancer [46][47][48][49][50][51][52][53][54][55][56][57][58][59], anti-inflammatory [45,[60][61][62], antibacterial [63,64], antioxidant [4,65,66], antiviral [67], larvicidal [68,69] Anticancer [46,47,58,59,70], anti-hyperglycemic [71], anti-inflammatory [25,62], antioxidant [4,65,66], antiviral [67], larvicidal [68,69] …”

Section: Chemistry and Classificationsmentioning

confidence: 99%

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The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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Section: Chemistry and Classificationsmentioning

confidence: 99%

“…The same group described the protective effects of 1 on experimentally-induced hepatic ischemia reperfusion (I/R) injury in rats. The mechanism of these hepatoprotective effects was related to the antioxidant and anti-inflammatory potential of 1 mediated by the down regulation of TLR-signaling pathway [61].…”

Section: Larvicidal and Insecticidal Activitiesmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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“…Berberine is the major pharmacologically active protoberberine alkaloids in Phellodendri amurensis cortex and Coptidis rhizoma. Previous studies showed that berberine has antibacterial, antiviral, antinociceptive, anti-inflammatory, and anti-carcinogenic effects (Mahmoud et al, 2014;Matsuda et al, 1998;Tundis et al, 2014). There is still little information concerning its anti-NBP mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…S1; supplementary material is available online at www .liebertpub.com/omi) is the major pharmacologically active protoberberine alkaloid in Phellodendri amurensis cortex and Coptidis rhizoma. Several studies have shown that berberine has antibacterial, antiviral, anti-nociceptive, anti-inflammatory, anti-carcinogenic in aflatoxin B1-induced hepatocellular carcinoma and inhibit p-glycoprotein (Mahmoud et al, 2014;Matsuda et al, 1998;Tundis et al, 2014). In vivo tests have shown that berberine inhibits carcinogen-induced tumor growth in various organs (Gong et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Berberine Ameliorates Nonbacterial Prostatitis via Multi-Target Metabolic Network Regulation

Sun

Wang

Zhang

et al. 2015

OMICS: A Journal of Integrative Biology

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Metabolomics has been increasingly applied to discovering biomarkers and identifying perturbed pathways. Berberine has been shown to exhibit anti-inflammatory, antioxidant, and anticancer properties, but its mechanisms for treating nonbacterial prostatitis (NBP) remain unclear completely. We developed the untargeted metabolomics approach based on UPLC-Q-TOF-HDMS to profile the metabolite changes in urine samples in order to discover novel potential biomarkers to clarify mechanisms of berberine in treating a rat model of capsaicin-induced nonbacterial prostatitis (NBP). The changes in metabolic profiling were restored to their base-line values after berberine treatment according to the principal component analysis (PCA) score plots. Fourteen different potential biomarkers and five acutely perturbed metabolic pathways contributing to the treatment of NBP were discovered and identified. Specifically, the berberine-treated rats are located closer to the normal group, indicating that the NBP-induced disturbances to the metabolic profile were partially reversed by berberine treatment. After treatment with berberine, the relative contents of 12 potential biomarkers were effectively regulated, which suggested that the therapeutic effects of berberine on NBP may involve regulating disturbances to the metabolism. Our results show that the protective effect of berberine occurs in part through a reversal of the NBP-caused disturbances.

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“…Limonoid are considered as one of the most important components of medical food (Mahmoud et al, 2014). Recently, limonin has been studied for its effects on p-gp.…”

Section: Limoninmentioning

confidence: 99%

Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals

Khan¹,

Maryam²,

Mehmood³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Multidrug resistance is a principal mechanism by which tumors become resistant to structurally and functionally unrelated anticancer drugs. Resistance to chemotherapy has been correlated with overexpression of p-glycoprotein (p-gp), a member of the ATP-binding cassette (ABC) superfamily of membrane transporters. P-gp mediates resistance to a broad-spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively expelling the drugs from cells. Use of specific inhibitors/blocker of p-gp in combination with clinically important anticancer drugs has emerged as a new paradigm for overcoming multidrug resistance. The aim of this paper is to review p-gp regulation by dietary nutraceuticals and to correlate this dietary nutraceutical induced-modulation of p-gp with activity of anticancer drugs.

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Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway

Cited by 60 publications

References 49 publications

The Chemistry and Pharmacology of Citrus Limonoids

The Chemistry and Pharmacology of Citrus Limonoids

Berberine Ameliorates Nonbacterial Prostatitis via Multi-Target Metabolic Network Regulation

Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals

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