Limonoids from Turraea holstii and Turraea floribunda

Anti-inflammatory, anticholinesterase, antioxidant and phytochemical properties of medicinal plants used for pain-related ailments in South Africa

“…Aloeresin-I could be a major compound responsible for the anti-inflammatory activity observed in some Aloe ferox leaf extracts. Moreover, compounds such as larvicidal tetranortriter- penoids in Turraea floribunda root and limonoids in the seed extract have been reported (Mulholland et al, 1998;McFarland et al, 2004;Ndung'u et al, 2004). In addition, a high inhibitory activity against COX enzymes has been reported in Turraea floribunda root EtOH extract (McGaw et al, 1998).…”

Limonoids from Turraea floribunda (Meliaceae)

“…The COSY spectrum indicated coupling between H-9 (d 2.80, d, 6.4 Hz), H-11 (d 5.43, dd 10.8, 6.4 Hz), and H-12 (5.71, d, 11.0 Hz). Literature investigations (Mulholland et al, 1998) have shown that when ring B is open, the C-11b,C-12a-substitution pattern is indicated by large coupling constants (J 9;11 ¼ 6-8 Hz; J 11;12 ¼ 7-11 Hz) and with the C-11a, C-12a-substitution pattern, the coupling constants are each less than 4 Hz. The 11b,12a-substitution pattern for turraflorin D was confirmed by use of the NOESY spectrum.…”

“…Previous analysis of the bark and rootbark has led to the isolation of havanensin-class limonoids (Akinniyi et al, 1986;Torto et al, 1995;Torto et al, 1996) and the seeds have previously yielded turraflorins A-C which are ring B opened limonoids of the turraflorin class (Mulholland et al, 1998;Fraser et al, 1994). The current reinvestigation of the seeds was undertaken to re-isolate turraflorin A which was required as a starting material for a synthetic project.…”

Vilasinin limonoids from Malleastrum antsingyense J.F. Leroy (Meliodeae: Meliaceae)

“…and Walsura Roxb., all of which are members of the subfamily Meliodeae of the Meliaceae. 1,3-diacetylvilasinin 1 itself has been reported from Melia volkensii Gürke (Rogers et al, 1998), Chisocheton paniculatus Hiern (Connolly et al, 1979), Azadirachta indica A.Juss (Kraus and Cramer, 1981), and two African Turraea species, Turraea holstii Gürke (Mulholland et al, 1998) andT. parvifolia Deflers (Cheplogoi andMulholland, 2003), while 1,3-diacetyl-12α-hydroxy-7-tigloylvilasinin 2 has been reported only from Azadirachta indica (Kumar et al, 1996).…”

“…plates, using hexane:EtOAc:MeOH mixtures, afforded a major component, 1,3-diacetylvilasinin (1, 1.8 g) (Mulholland et al, 1998), together with 1,3-diacetyl-12α-hydroxy-7-tigloylvilasinin (2, 10 mg) (Kumar et al, 1996), and several other minor components which were visible on TLC but could not be isolated in sufficient quantities for identification. The structures of the isolated compounds were established by analysis of their spectroscopic data and comparison with values reported in the literature.…”