Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

Pushpalatha, Rajangam; Sindhu, Ganapathy; Sharmila, R.; Tamizharasi, G.; Vennila, Lakshmanan; Vijayalakshmi, Annamalai

doi:10.36468/pharmaceutical-sciences.842

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The initial phase arrest was caused by linalool in a time- and dose-dependent way. Linalool demonstrated its potential as a strong growth inhibitory agent for keratin-forming tumor cells by efficiently reducing cell survival in vitro 18 .…”

Section: Outcomes Of In Vitro Investigationsmentioning

confidence: 99%

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications

Singh,

Mishra

2024

Drug Res (Stuttg)

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This comprehensive review endeavors to illuminate the nuanced facets of linalool, a prominent monoterpene found abundantly in essential oils, constituting a massive portion of their composition. The biomedical relevance of linalool is a key focus, highlighting its therapeutic attributes observed through anti-nociceptive effects, anxiolytic properties, and behavioral modulation in individuals affected by dementia. These findings underscore the compound's potential application in biomedical applications. This review further explores contemporary formulations, delineating the adaptability of linalool in nano-emulsions, microemulsions, bio-capsules, and various topical formulations, including topical gels and lotions. This review covers published and granted patents between 2018–2024 and sheds light on the evolving landscape of linalool applications, revealing advancements in dermatological, anti-inflammatory, and antimicrobial domains.

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Section: Outcomes Of In Vitro Investigationsmentioning

confidence: 99%

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications

Singh,

Mishra

2024

Drug Res (Stuttg)

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“…α-terpineol [172] and linalool [173] also showed strong cytotoxicity on HeLa cells with apoptosis and cell cycle arrest. In human acute myeloid leukemia U937 cells [173], human oral cancer cells [174,175], and lung adenocarcinoma A549 cells [176], linalool significantly suppressed the cell growth. D-limonene [177] and d-limonene-rich blood orange volatile oils [178] inhibited the proliferation of lung cancer A549 and H1299 cells and human colon adenocarcinoma cells SW480 and HT-29 cells, respectively.…”

Section: Cancermentioning

confidence: 99%

Volatiles in Berries: Biosynthesis, Composition, Bioavailability, and Health Benefits

Howard

Lee

2022

Applied Sciences

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Volatile compounds in fruits are responsible for their aroma. Among fruits, berries contain many volatile compounds, mainly esters, alcohols, terpenoids, aldehydes, ketones, and lactones. Studies for volatile compounds in berries have increased extensively as the consumption of berry products rapidly increased. In this paper, we reviewed biosynthesis and profiles of volatiles in some berries (strawberry, blueberry, raspberry, blackberry, and cranberry) and their bioavailability and health benefits, including anti-inflammatory, anti-cancer, anti-obesity, and anti-diabetic effects in vitro and in vivo. Each berry had different major volatiles, but monoterpene had an important role in all berries as aroma-active components. Volatile compounds were nonpolar and hydrophobic and rapidly absorbed and eliminated from our body after administration. Among them, monoterpenes, including linalool, limonene, and geraniol, showed many health benefits against inflammation, cancer, obesity, and diabetes in vitro and in vivo. More research on the health benefits of volatile compounds from berries and their bioavailability would be needed to confirm the bioactivities of berry volatiles.

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Potential Health Benefits of Fruits and Vegetables II

2023

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Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

Cited by 3 publications

References 28 publications

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications

Volatiles in Berries: Biosynthesis, Composition, Bioavailability, and Health Benefits

Potential Health Benefits of Fruits and Vegetables II

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