LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p

Han, Xiancheng; Liu, Jing; Liu, Yongguo; Mou, Linkai; Li, Chunlong

doi:10.2147/cmar.s305547

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…Using Cox regression and Lasso regression, we developed a prognostic model consisting of nine lncRNAs (AC010331.1, LINC-PINT, AC006160.1, LINC00536, AL590428.1, MSC-AS1, AC104785.1, AC243654.1, and AC022364.1). LINC-PINT is a promising prognostic marker for bladder cancer, and its upregulation can suppress the proliferation, invasion, and migration of bladder cancer cells by targeting miR-155-5p [ 16 ]. The lncRNA AC006160.1 may serve as a protective factor for the progression of bladder cancer [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Preliminary findings on the development of a predictive model for BLCA based on disulfidptosis-associated IncRNAs signature

Tang,

Fan,

Zhu

2024

BMC Urol

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Background Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, presenting with a wide range of clinical symptoms and prognosis. Disulfidptosis is a newly identified cell death method and closely associated with BLCA progression, prognosis, and treatment outcome. Currently, we need to construct a new prognostic model for disulfidptosis-related long noncoding RNAs (drlncRNAs) to improve the treatment strategy of BLCA. Methods The data for BLCA samples were obtained from The Cancer Genome Atlas (TCGA), and then 10 unique genes related to disulfidoptosis (DRGs) were identified from research papers. The differences between the two groups showed in this study were used to create the “disulfidptosis-related long noncoding RNAs score” (disulfidptosis-score) prognostic model. Results We identified two groups of drlncRNAs with high and low disulfidptosis scores in this study. Patients with low disulfidptosis scores had a better overall survival rate compared to those with high scores in bladder cancer, and the high disulfidptosis score subtype exhibited more active malignant pathways related to cancer than the low score subtype. We found that the low disulfidptosis-score subgroup had better prognosis than the high disulfidptosis-score subgroup. The expression of mutation burden was much higher in the low disulfidptosis-score group than in the high disulfidptosis-score group. The low disulfidptosis-score subgroup of patients exhibited significantly higher proportions of plasma cells, T cells CD8, and Tregs, while the high-risk subgroup had a greater abundance of Macrophages M0 and Macrophages M2. The disulfidptosis-score showed a strong correlation with the sensitivity of chemotherapeutic drugs, and patients in the low disulfidptosis-score group were more likely to exhibit an immune response and respond positively to immunotherapy. Additionally, we developed a nomogram to enhance the accuracy of the disulfidptosis-clinical score. Conclusion Based on our investigation of disulfidptosis-score in BLCA, disulfidptosis-score may have an important role in TME, prognosis, and drug sensitivity. We also investigated the significance of the disulfidoptosis-score in relation to immunotherapy and immune response, providing a basis for improving prognosis and responding to immunotherapy among patients with BLCA.

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Section: Discussionmentioning

confidence: 99%

Preliminary findings on the development of a predictive model for BLCA based on disulfidptosis-associated IncRNAs signature

Tang,

Fan,

Zhu

2024

BMC Urol

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“…Accumulating evidence suggested that abnormally expressed circRNAs were involved in the regulation of septic AKI progression through a competing endogenous RNA (ceRNA) mechanism (13,14). MiR-155-5p has been confirmed to play a tumor-promoting role in various cancers including cholangiocarcinoma (27), bladder cancer (28), breast cancer (29), and renal cell carcinoma (30). On the other hand, miR-155-5p served as an anti-cancer factor in various cancers including ovarian cancer (31), anaplastic thyroid cancer (32), and osteosarcoma (33).…”

Section: Discussionmentioning

confidence: 99%

Circ_0008882 Stimulates Pde7a to Suppress Septic Acute Kidney Injury Progression by Sponging Mir-155-5p

You

Feng

2023

Shock

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Background: The importance of circular RNA (circRNA) in the progression of septic acute kidney injury (AKI) was gradually recognized. It has been confirmed that circ_0008882 expression was decreased in the blood of patients with AKI. However, the role of circ_0008882 in septic AKI progression remains unclear. Methods: Human kidney-2 (HK2) cells were stimulated with lipopolysaccharide (LPS) to establish a septic AKI cell model. The RNA and protein expression of circ_0008882, miR-155-5p, phosphodiesterase 7A (PDE7A), PCNA, Bax, and Bcl-2 were detected by quantitative real-time polymerase chain reaction and Western blot. Cell viability was investigated by cell counting kit-8 assay. Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the levels of inflammatory factors (TNF-α, IL-1β, and IL-6). Flow cytometry was implemented to evaluate cell cycle and cell apoptosis. The Caspase3 activity was examined using Caspase3 Assay Kit. Dual-luciferase reporter assay and RNA immunoprecipitation assay were applied to verify the molecular target relations. Results: Septic AKI serum samples and LPS-induced HK2 cells displayed low expression of circ_0008882 and PDE7A, and high expression of miR-155-5p when compared with the controls. Overexpression of circ_0008882 relieved LPS-induced HK2 cell injury. MiR-155-5p was a target of circ_0008882, and miR-155-5p mimic restored circ_0008882 overexpression-mediated effects on LPS-treated HK2 cells. PDE7A was identified as a target gene of miR-155-5p, and PDE7A downregulation almost reverted the improvement impacts induced by the miR-155-5p inhibitor. Conclusions: Overexpression of circ_0008882 impeded LPS-induced HK2 cell injury by modulating miR-155-5p/PDE7A pathway, implying that circ_0008882 might be a possible circRNA-targeted therapy for septic AKI.

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“…Therefore, miR-192-5p could be potentially used for therapeutic and diagnostic goals 77 . miR-155-5p , which was downregulated in BC 78 , nasopharyngeal carcinoma, oral cancer, as well as colon cancer 79 , 80 .…”

Section: Discussionmentioning

confidence: 99%

mRNA–miRNA bipartite networks reconstruction in different tissues of bladder cancer based on gene co-expression network analysis

Abedi

MotieGhader

Hosseini

et al. 2022

Sci Rep

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Bladder cancer (BC) is one of the most important cancers worldwide, and if it is diagnosed early, its progression in humans can be prevented and long-term survival will be achieved accordingly. This study aimed to identify novel micro-RNA (miRNA) and gene-based biomarkers for diagnosing BC. The microarray dataset of BC tissues (GSE13507) listed in the GEO database was analyzed for this purpose. The gene expression data from three BC tissues including 165 primary bladder cancer (PBC), 58 normal looking-bladder mucosae surrounding cancer (NBMSC), and 23 recurrent non-muscle invasive tumor tissues (RNIT) were used to reconstruct gene co-expression networks. After preprocessing and normalization, deferentially expressed genes (DEGs) were obtained and used to construct the weighted gene co-expression network (WGCNA). Gene co-expression modules and low-preserved modules were extracted among BC tissues using network clustering. Next, the experimentally validated mRNA-miRNA interaction information were used to reconstruct three mRNA-miRNA bipartite networks. Reactome pathway database and Gene ontology (GO) was subsequently performed for the extracted genes of three bipartite networks and miRNAs, respectively. To further analyze the data, ten hub miRNAs (miRNAs with the highest degree) were selected in each bipartite network to reconstruct three bipartite subnetworks. Finally, the obtained biomarkers were comprehensively investigated and discussed in authentic studies. The obtained results from our study indicated a group of genes including PPARD, CST4, CSNK1E, PTPN14, ETV6, and ADRM1 as well as novel miRNAs (e.g., miR-16-5p, miR-335-5p, miR-124-3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker. Afterward, three drug-gene interaction networks were reconstructed to explore candidate drugs for the treatment of BC. The hub miRNAs in the mRNA-miRNA bipartite network played a fundamental role in BC progression; however, these findings need further investigation.

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LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p

Cited by 14 publications

References 37 publications

Preliminary findings on the development of a predictive model for BLCA based on disulfidptosis-associated IncRNAs signature

Preliminary findings on the development of a predictive model for BLCA based on disulfidptosis-associated IncRNAs signature

Circ_0008882 Stimulates Pde7a to Suppress Septic Acute Kidney Injury Progression by Sponging Mir-155-5p

mRNA–miRNA bipartite networks reconstruction in different tissues of bladder cancer based on gene co-expression network analysis

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