Linc<scp>RNA</scp>‐p21 suppresses development of human prostate cancer through inhibition of <scp>PKM</scp>2

Wang, Xiaohai; Xu, Yongzhi; Wang, Xingjie; Jiang, Chuanwen; Han, Shuang; Dong, Kai; Shen, Min; Xu, Danfeng

doi:10.1111/cpr.12395

Cited by 43 publications

(29 citation statements)

References 33 publications

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“…LincRNA-p21, a downstream transcriptional target of p53, can be upregulated upon DNA damage to repress the transcription of p53 targeted genes [57]. LincRNA-p21 knockdown upregulates PKM2 expression through PTEN/AKT/mTOR pathway, thus activating glycolysis and enabling prostate cancer progression [58]. Moreover, lincRNA-p21 is upregulated by HIF-1α and reciprocally binds to HIF-1α, preventing HIF-1α from degradation by interrupting HIF-1α-VHL interaction.…”

Section: Lncrnas Regulate Glucose Metabolismmentioning

confidence: 99%

LncRNAs regulate metabolism in cancer

et al. 2020

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Metabolic reprogramming is a hallmark of cancer. Mammalian genome is characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are freshly discovered functional ncRNAs exerting extensive regulatory impact through diverse mechanisms. Emerging studies have revealed widespread roles of lncRNAs in the regulation of various cellular activities, including metabolic pathways. In this review, we summarize the latest advances regarding the regulatory roles of lncRNAs in cancer metabolism, particularly their roles in mitochondrial function, glucose, glutamine, and lipid metabolism. Moreover, we discuss the clinical application and challenges of targeting lncRNAs in cancer metabolism. Understanding the complex and special behavior of lncRNAs will allow a better depiction of cancer metabolic networks and permit the development of lncRNA-based clinical therapies by targeting cancer metabolism.

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Section: Lncrnas Regulate Glucose Metabolismmentioning

confidence: 99%

LncRNAs regulate metabolism in cancer

et al. 2020

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“…A single study reported that LincRNA-p21 suppresses the development of PCa [ 32 ]. LincRNA-p21 expression inhibited PCa cell proliferation and colony formation in vitro and reduced the rate of PCa cell population growth in vivo .…”

Section: Lncrnas Associated With Prostate Cancermentioning

confidence: 99%

Carcinogenesis in prostate cancer: The role of long non-coding RNAs

Aird

Baird

Lim

et al. 2018

Non-coding RNA Research

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LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway.

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“…With regard to the function of MALAT1 in specific cells, the present study hypothesized that an interaction between MALAT1 and p53 exists in colorectal neoplasms. Previous studies have assessed the expression of lincRNA-p21 with various types of cancer (18,35,36). However, few studies report the influence of lincRNa-p21 on CRC.…”

Section: Lncrna-rormentioning

confidence: 99%

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

et al. 2020

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Colorectal cancer (CRC) is a common intestinal cancer with a high mortality rate. Early detection of this type of cancer is fundamental to the prevention of the disease, which results in improved survival rates. In the human colon tissue, transition from normal epithelium to adenoma is considered to be caused by unknown molecular incidents occurring over 5-10 years. The detection of CRC has proved problematic when in the early stages of disease. In addition, identifying suitable biomarkers for the detection of CRC progress in patients remains one of the most significant challenges. Long non-coding RNAs have been demonstrated to contribute to the promotion of CRC. The aim of the present study was to investigate the clinical and biological significance of long intergenic non-coding (linc)RNA-p21, lincRNA-regulator of reprogramming (ROR) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the colon tumor and polyp tissue, and the association that these have with the expression of p53 at the mRNA level. Neoplastic and paired adjacent normal tissue samples were obtained from 72 patients (46 polyps and 26 tumors). Reverse transcription-quantitative PCR was performed to determine the relative fold changes in the expression of lincRNA-p21, lincRNA-RoR, MALAT1 and p53 in the samples. A significant association was observed between the levels of MALAT1 and p53 in neoplasm tissues (R=0.073; P<0.05). The relative expression of the MALAT1 gene revealed a statistically significant difference between the different polyp types and number of polyps (P=0.0028 and 0.022, respectively). Adjuvant therapy in patients with tumors revealed an association between the levels of lincRNA-ROR and lincRNA-p21 expression (P=0.015 and 0.038, respectively). MALAT1 may be selected as an early detection biomarker for CRC. Furthermore, lincRNA-ROR and lincRNA-p21 may serve as prognostic and therapeutic biomarkers in patients with CRC.

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LincRNA‐p21 suppresses development of human prostate cancer through inhibition of PKM2

Abstract: We demonstrated that lincRNA-p21 blunted the prostate cancer cell proliferation and tumorigenic capacity through down-regulation of PKM2. Therefore, targeting PKM2 or glycolysis might be a therapeutic strategy in prostate cancer patients with lowly expressed lincRNA-p21.

Cited by 43 publications

References 33 publications

LncRNAs regulate metabolism in cancer

LncRNAs regulate metabolism in cancer

Carcinogenesis in prostate cancer: The role of long non-coding RNAs

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

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