LINC00467: A key oncogenic long non-coding RNA

Changizian, Mohammad; Nourisanami, Farahdokht; Hajpoor, Vida; Parvaresh, Maryam; Bahri, Zahra; Motovali-Bashi, Majid

doi:10.1016/j.cca.2022.09.013

Cited by 2 publications

(2 citation statements)

References 98 publications

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“…LINC00467 can also act as a ceRNA and, thus, participate in the regulation of signalling pathways (e.g., EGFR) and tumorigenesis [284]. It correlates with the clinical stage of various cancer types, with their poor prognosis and survival time [281,[285][286][287][288]. Interestingly, this lncRNA can encode a short ASAP peptide.…”

Section: Emerging Lncrna Biomarkers Of Gbmmentioning

confidence: 99%

lncRNA Biomarkers of Glioblastoma Multiforme

Pokorná,

Černá,

Boussios

et al. 2024

Biomedicines

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Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is tissue-specific, with the vast majority involved in the regulation of cellular processes and functions. Many human diseases, including cancer, have been shown to be associated with deregulated lncRNAs, rendering them potential therapeutic targets and biomarkers for differential diagnosis. The expression of lncRNAs in the nervous system varies in different cell types, implicated in mechanisms of neurons and glia, with effects on the development and functioning of the brain. Reports have also shown a link between changes in lncRNA molecules and the etiopathogenesis of brain neoplasia, including glioblastoma multiforme (GBM). GBM is an aggressive variant of brain cancer with an unfavourable prognosis and a median survival of 14–16 months. It is considered a brain-specific disease with the highly invasive malignant cells spreading throughout the neural tissue, impeding the complete resection, and leading to post-surgery recurrences, which are the prime cause of mortality. The early diagnosis of GBM could improve the treatment and extend survival, with the lncRNA profiling of biological fluids promising the detection of neoplastic changes at their initial stages and more effective therapeutic interventions. This review presents a systematic overview of GBM-associated deregulation of lncRNAs with a focus on lncRNA fingerprints in patients’ blood.

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Section: Emerging Lncrna Biomarkers Of Gbmmentioning

confidence: 99%

lncRNA Biomarkers of Glioblastoma Multiforme

Pokorná,

Černá,

Boussios

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…LincRNAs have a wide range of functions, including regulating epigenetic changes and regulating gene expression, as well as acting as scaffolds for protein signaling complexes [26]. LincRNA genes differ from mRNAencoding genes in that they perform crucial roles such as chromatin remodeling and genome architectural remodeling, RNA stabilization or enhancer-associated activity [27], and finally, transcription regulation/control of neighbor genes as well [28].…”

Section: What Are Lincrnas?mentioning

confidence: 99%

The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision

Eldash,

Sanad,

Nada

et al. 2023

ncRNA

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Background: Long intergenic non-coding RNA, is one type of lncRNA, exerting various cellular activities, as does ncRNA, including the regulation of gene expression and chromatin remodeling. The abnormal expression of lincRNAs can induce or suppress carcinogenesis. Main body: LincRNAs can regulate cancer progression through different mechanisms and are considered as potential drug targets. Genetic variations such as single nucleotide polymorphisms (SNPs) in lincRNAs may affect gene expression and messenger ribonucleic acid (mRNA) stability. SNPs in lincRNAs have been found to be associated with different types of cancer, as well. Specifically, LINC00511 has been known to promote the progression of multiple malignancies such as breast cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, and others, making it a promising cancer prognostic molecular marker. Conclusion: LincRNAs have been proved to be associated with different cancer types through various pathways. Herein, we performed a comprehensive literature and in silico databases search listing lncRNAs, lincRNAs including LINC00511, lncRNAs’ SNPs, as well as LINC00511 SNPs in different cancer types, focusing on their role in various cancer types and mechanism(s) of action.

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LINC00467: A key oncogenic long non-coding RNA

Cited by 2 publications

References 98 publications

lncRNA Biomarkers of Glioblastoma Multiforme

lncRNA Biomarkers of Glioblastoma Multiforme

The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision

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