Linc00641 promotes the progression of gastric carcinoma by modulating the miR-429/Notch-1 axis

Hang, Qun; Lü, Jie; Zuo, Lugen; Liu, Mulin

doi:10.18632/aging.202661

Cited by 9 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified 144 key m6A-related lncRNAs, nine of which were included in the MLPS. LINC00641 was reported to be an oncogene in acute myeloid leukaemia ( 26 ), colorectal carcinoma ( 27 ) and gastric carcinoma ( 28 ). Conversely, LINC00641 has been studied and reported as a tumor inhibitor in many cancers, including prostate cancer ( 29 ), bladder cancer ( 30 ), renal cancer ( 31 ), cervical cancer ( 32 ), non-small-cell lung cancer ( 33 ) and breast cancer ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma

Chen

Guo

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

N6-methyladenosine (m6A) modification is the most abundant modification in long noncoding RNAs (lncRNAs). Current studies have shown that the abnormal expression of m6A-related genes is closely associated with the tumorigenesis and progression of glioma. However, the role of m6A-related lncRNAs in glioma development is still unclear. Herein, we screened 566 m6A-related lncRNAs in glioma from The Cancer Genome Atlas (TCGA) database. The expression pattern of these lncRNAs could cluster samples into two groups, in which various classical tumor-related functions and the tumor immune microenvironment were significantly different. Subsequently, a nine-factor m6A-related lncRNA prognostic signature (MLPS) was constructed by using a LASSO regression analysis in the training set and was validated in the test set and independent datasets. The AUC values of the MLPS were 0.881, 0.918 and 0.887 for 1-, 3- and 5-year survival in the training set, respectively, and 0.856, 0.916 and 0.909 for 1-, 3-, and 5-year survival in the test set, respectively. Stratification analyses of the MLPS illustrated its prognostic performance in gliomas with different characteristics. Correlation analyses showed that the infiltrations of monocytes and tumor-associated macrophages (TAMs) were significantly relevant to the risk score in the MLPS. Moreover, we detected the expression of four MLPS factors with defined sequences in glioma and normal cells by using RT–PCR. Afterwards, we investigated the functions of LNCTAM34A (one of the MLPS factors) in glioma cells, which have rarely been reported. Via in vitro experiments, LNCTAM34A was demonstrated to promote the proliferation, migration and epithelial-mesenchymal transition (EMT) of glioma cells. Overall, our study revealed the critical role of m6A-related lncRNAs in glioma and elucidated that LNCTAM34A could promote glioma proliferation, migration and EMT.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma

Chen

Guo

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…LINC00641 and miR-582-5p participate in the regulation of oxaliplatin resistance by altering autophagy in gastric adenocarcinoma, providing a direction for the treatment of gastric cancer. Hang et al ( 38 ) also found that silencing LINC00641 in gastric cancer cell line reduced the proliferation, migration and invasion of cancer cells and induced apoptosis. After down regulating LINC00641 in cells, the expression of miR-429 increased.…”

Section: Role Of Linc00641 In Cancermentioning

confidence: 97%

“…Liu ( 36 ) analyzed 23 prostate cancer patients and found that the low LINC00641 expression group had a lower survival rate than the high LINC00641 expression group (P < 0.05). Hu ( 38 ) detected the expression of LINC00641 in 173 cases of gastric cancer, which was related to M stage (P < 0.01). Cox regression model including LINC00641, miR-582-5p, CEA and age could predict the 1-year and 3-year survival rates of gastric cancer patients (C index was 0.876 ± 0.06).…”

Section: Clinical Significance Of Linc00641mentioning

confidence: 98%

“…As an oncogene: in leukemia cell lines, silencing LINC00641 inhibits the proliferation, migration and invasion of cancer cells, causes cell cycle arrest and induces apoptosis ( 40 ). Silencing LINC00641 reduces the proliferation, migration and invasion of cancer cells and induces apoptosis in gastric cancer cell lines ( 38 ), and LINC00641 participates in regulating oxaliplatin resistance by changing autophagy in gastric adenocarcinoma, providing a direction for the treatment of gastric cancer ( 45 ). When LINC00641 was knocked down, the proliferation and migration of rectal cancer cells decreased ( 46 ).…”

Section: Clinical Significance Of Linc00641mentioning

confidence: 99%

“…More and more evidence show that LINC00641 is differentially expressed in a variety of tumors and is associated with overall survival and prognosis (35)(36)(37). LINC00641 can participate in the regulation of proliferation, invasion, metastasis and apoptosis of a variety of tumors (38)(39)(40). A search of NCBI database revealed that LINC00641 gene sequence could be transcribed into two transcripts: NR_038970.1 and NR_038971.1 (Figure 2).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Role of Long Non-Coding RNA LINC00641 in Cancer

Han

Zhang

2022

Front. Oncol.

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are non-protein coding RNAs with more than 200 nucleic acids in length. When lncRNAs are located in the nucleus, they regulate chromosome structure, participate in chromatin remodeling, and act as transcription regulators. When lncRNAs are exported to the cytoplasm, they regulate mRNA stability, regulate translation, and interfere with post-translational modification. In recent years, more and more evidences have shown that lncRNA can regulate the biological processes of tumor proliferation, apoptosis, invasion and metastasis, and can participate in a variety of tumor signaling pathways. Long-gene non-protein coding RNA641 (LINC00641), located on human chromosome 14q11.2, is differentially expressed in a variety of tumors and is related to overall survival and prognosis, etc. Interfering the expression of LINC00641 can lead to changes in tumor cell proliferation, invasion, metastasis, apoptosis and other biological behaviors. Therefore, LINC00641 is a promising new biomarker and potential clinical therapeutic target. In this review, the biological functions, related mechanisms and clinical significance of LINC00641 in many human cancers are described in detail.

show abstract

A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer

Gupta,

Ahmed,

Tayyib

et al. 2023

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Linc00641 promotes the progression of gastric carcinoma by modulating the miR-429/Notch-1 axis

Cited by 9 publications

References 31 publications

Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma

Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma

Role of Long Non-Coding RNA LINC00641 in Cancer

A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer

Contact Info

Product

Resources

About