LINC00665 interacts with BACH1 to activate Wnt1 and mediates the M2 polarization of tumor-associated macrophages in GC

Yang, Bo; Su, Kun; Sha, Guanyu; Bai, Qingqing; Sun, Gengxin; Chen, Huidong; Xie, Hongmei; Jiang, Xuan

doi:10.1016/j.molimm.2022.03.120

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…Furthermore, CCL2 triggered the transcription of ZC3H12A, which upregulated K63‐linked deubiquitination and K48‐linked auto‐ubiquitination of TRAF6/3 to inhibit NF‐κB signalling, thereby reducing M1 TAMs in the TME of HER2‐positive GC 16 . Also, the non‐coding RNAs (lncRNA ANCR, LINC00665 and lncRNA NR_109) were reported to enhance the polarisation of M2 TAMs in GC 87–89 . Calmodulin 2 was reported to induce the polarisation of M2 TAMs by activating JAK2 or HIF‐1 in macrophages 90 .…”

Section: The Role and Mechanism Of Tams In Gcmentioning

confidence: 99%

Tumour‐associated macrophages in gastric cancer: From function and mechanism to application

Li,

Sun,

Zeng

et al. 2023

Clinical & Translational Med

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BackgroundGastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evidence shows that tumour‐associated macrophages (TAMs) play a vital role in GC, acting as plentiful and active infiltrating inflammatory cells in the TME.Main bodyIn this review, the different functions and mechanisms of TAMs in GC progression, including the conversion of phenotypic subtypes; promotion of tumour proliferation, invasion and migration; induction of chemoresistance; promotion of angiogenesis; modulation of immunosuppression; reprogramming of metabolism; and interaction with the microbial community are summarised. Although the role of TAMs in GC remains controversial in clinical settings, clarifying their significance in the treatment selection and prognostic prediction of GC could support optimising TAM‐centred clinicaltherapy.ConclusionIn summary, we reviewed the the phenotypic polarisation, function and molecular mechanism of TAMs and their potential applications in the treatment selection and prognostic prediction of GC.

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Section: The Role and Mechanism Of Tams In Gcmentioning

confidence: 99%

Tumour‐associated macrophages in gastric cancer: From function and mechanism to application

Li,

Sun,

Zeng

et al. 2023

Clinical & Translational Med

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“…TAMs act as potential therapeutic targets for GC: As a potential therapeutic target in GC, TAMs can be reprogrammed into a proinflammatory subtype by targeting many pathways (Table 2 ), such as the stimulator of interferon genes (STING) pathway[ 67 ]. At the RNA level, LINC00665 interfaces with transcription factor BTB domain and CNC homology 1 to activate Wnt1 and mediates M2 polarization of TAMs in GC[ 68 ]. Many proteins can also mediate TAM polarization (calmodulin 2[ 69 ], methionine enkephalin[ 70 ], ETS-like transcription factor 4[ 71 ], IL-6[ 72 ], and IL-8[ 73 ]) and repress TAM activation (vasoactive intestinal peptide[ 74 ]), via signaling pathways such as STAT3/HIF-1A/VEGF-A axis[ 69 ], opioid growth factor receptor/PI3K/AKT/mammalian target of rapamycin (mTOR) axis[ 70 ], and IL-6/STAT3/interferon regulatory factor 4 axis[ 72 ], and so on.…”

Section: Tams and Targeted Therapies Of Digestive System Malignant Tu...mentioning

confidence: 99%

Role of tumor-associated macrophages in common digestive system malignant tumors

Shen¹,

Chen²,

Li³

et al. 2023

World J Gastrointest Oncol

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Many digestive system malignant tumors are characterized by high incidence and mortality rate. Increasing evidence has revealed that the tumor microenvironment (TME) is involved in cancer initiation and tumor progression. Tumor-associated macrophages (TAMs) are a predominant constituent of the TME, and participate in the regulation of various biological behaviors and influence the prognosis of digestive system cancer. TAMs can be mainly classified into the antitumor M1 phenotype and protumor M2 phenotype. The latter especially are crucial drivers of tumor invasion, growth, angiogenesis, metastasis, immunosuppression, and resistance to therapy. TAMs are of importance in the occurrence, development, diagnosis, prognosis, and treatment of common digestive system malignant tumors. In this review, we summarize the role of TAMs in common digestive system malignant tumors, including esophageal, gastric, colorectal, pancreatic and liver cancers. How TAMs promote the development of tumors, and how they act as potential therapeutic targets and their clinical applications are also described.

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“…Fang et al showed using bioinformatics analyses that BACH1 overexpression indicated good prognosis in patients with GC ( Fang and Lu, 2020 ). A recent study revealed that BACH1 facilitates the polarization of macrophages towards the M2 phenotype by activating Wnt1 and promotes macrophage-dependent GC progression ( Yang et al, 2022 ). These somewhat contradictory results suggest that the role of BACH1 in GC is complex and may be related to the tumor immune microenvironment.…”

Section: Pancreatic Diseasesmentioning

confidence: 99%

Pathophysiological role of BACH transcription factors in digestive system diseases

et al. 2023

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BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism. In this review, we discuss the function of BACH proteins in the digestive system, including the liver, gallbladder, esophagus, stomach, small and large intestines, and pancreas. BACH proteins directly target genes or indirectly regulate downstream molecules to promote or inhibit biological phenomena such as inflammation, tumor angiogenesis, and epithelial-mesenchymal transition. BACH proteins are also regulated by proteins, miRNAs, LncRNAs, labile iron, and positive and negative feedback. Additionally, we summarize a list of regulators targeting these proteins. Our review provides a reference for future studies on targeted drugs in digestive diseases.

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LINC00665 interacts with BACH1 to activate Wnt1 and mediates the M2 polarization of tumor-associated macrophages in GC

Cited by 13 publications

References 27 publications

Tumour‐associated macrophages in gastric cancer: From function and mechanism to application

Tumour‐associated macrophages in gastric cancer: From function and mechanism to application

Role of tumor-associated macrophages in common digestive system malignant tumors

Pathophysiological role of BACH transcription factors in digestive system diseases

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