LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A

Liu, Ye-Ling; Chen, Jingrui; Zhou, Liche; Chen, Yin

doi:10.1186/s13062-021-00314-6

Cited by 13 publications

(11 citation statements)

References 34 publications

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“…36 Current research has focused on breast and cervical cancers, but LINC00885 expression in OTSCC remains unclear. 37,38 Our findings revealed that LINC00885 is also upregulated in OTSCC. Therefore, the prognostic signature model based on the target gene of LINC00885 has high predictive efficacy in predicting the patient's prognosis after surgery or treatment.…”

Section: Discussionmentioning

confidence: 54%

Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

Liu

Ying

et al. 2023

Int J Oral Sci

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Tongue squamous cell carcinoma is highly malignant and has a poor prognosis. In this study, we aimed to combine whole-genome sequencing, whole-genome methylation, and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma better. Oral tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired samples. After multi-omics sequencing, differentially methylated intervals, methylated loop sites, methylated promoters, and transcripts were screened for variation in all paired samples. Correlations were analyzed to determine biological processes in tongue squamous cell carcinoma. We found five mutated methylation promoters that were significantly associated with mRNA and lncRNA expression levels. Functional annotation of these transcripts revealed their involvement in triggering the mitogen-activated protein kinase cascade, which is associated with cancer progression and the development of drug resistance during treatment. The prognostic signature models constructed based on WDR81 and HNRNPH1 and combined clinical phenotype–gene prognostic signature models showed high predictive efficacy and can be applied to predict patient prognostic risk in clinical settings. We identified biological processes in tongue squamous cell carcinoma that are initiated by mutations in the methylation promoter and are associated with the expression levels of specific mRNAs and lncRNAs. Collectively, changes in transcript levels affect the prognosis of tongue squamous cell carcinoma patients.

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Section: Discussionmentioning

confidence: 54%

Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

Liu

Ying

et al. 2023

Int J Oral Sci

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“…Previous studies have shown that overexpression of BAZ2A can predict tprostate cancer recurrence [ 65 ]. In addition, BAZ2A can have a regulatory role in hepatocellular carcinoma, cervical cancer, and chronic lymphoblastic leukemia [ 66 , 67 , 68 ]. MicroRNA (miRNA) is a noncoding RNA that pairs with target messenger RNA (mRNA) in a sequence-specific manner to regulate the expression of target genes [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms Associated with Prothrombin Time and Activated Partial Thromboplastin Time in Chinese Healthy Population

Zhang

Mu²,

Liu³

et al. 2022

Genes

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(1) Background: The purpose of this study was to evaluate the effect of gene polymorphisms on prothrombin time (PT) and activated partial thromboplastin time (APTT) in a healthy Chinese population. (2) Methods: A total of 403 healthy volunteers from a series of novel oral anticoagulants (NOACs) bioequivalence trials in China were included. Coagulation tests for PT and APTT were performed in the central lab at Peking University First Hospital. Whole-exome sequencing (WES) and genome-wide association analysis were performed. (3) Results: In the correlation analysis of PT, 105 SNPs from 84 genes reached the genome-wide significance threshold (p < 1 × 10−5). Zinc Finger Protein 594 (ZNF594) rs184838268 (p = 4.50 × 10−19) was most significantly related to PT, and Actinin Alpha 1 (ACTN1) was found to interact most with other candidate genes. Significant associations with previously reported candidate genes Aurora Kinase B (AURKB) , Complement C5(C5), Clock Circadian Regulator (CLOCK), and Histone Deacetylase 9(HDAC9) were detected in our dataset (p < 1 × 10−5). PiggyBac Transposable Element Derived 2(PGBD2) rs75935520 (p = 4.49 × 10−6), Bromodomain Adjacent To Zinc Finger Domain 2A(BAZ2A) rs199970765 (p = 5.69 × 10−6) and Protogenin (PRTG) rs80064850 (p = 8.69 × 10−6) were significantly correlated with APTT (p < 1 × 10−5). The heritability values of PT and APTT were 0.83 and 0.64, respectively; (4) Conclusion: The PT and APTT of healthy populations are affected by genetic polymorphisms. ZNF594 and ACTN1 variants could be novel genetic markers of PT, while PRTG polymorphisms might be associated with APTT levels. The findings could be attributed to ethnic differences, and need further investigation.

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“…RNA samples were treated with RNase-free DNase I (Qiagen), and RNA was quantified using a NanoDrop spectrophotometer (Thermo Scientific, Waltham, MA, USA). Total RNA was reverse-transcribed using Superscript III reverse transcriptase and oligo(dT) primer (Invitrogen) [ 78 , 79 ]. qRT-PCR was performed in ABI PRISM 7000 Sequence Detection System (Applied Biosystem, Waltham, MA, USA) with SYBR green ready mix (Applied Biosystem) and specific primers:…”

Section: Methodsmentioning

confidence: 99%

ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer

Montanaro

Agostini

Anemona

et al. 2023

IJMS

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Prostate cancer is the most frequently diagnosed cancer and the fifth leading cause of cancer death among men in 2020. The clinical decision making for prostate cancer patients is based on the stratification of the patients according to both clinical and pathological parameters such as Gleason score and prostate-specific antigen levels. However, these tools still do not adequately predict patient outcome. The aim of this study was to investigate whether ZNF750 could have a role in better stratifying patients, identifying those with a higher risk of metastasis and with the poorest prognosis. The data reported here revealed that ZNF750 protein levels are reduced in human prostate cancer samples, and this reduction is even higher in metastatic samples. Interestingly, nuclear positivity is significantly reduced in patients with metastatic prostate cancer, regardless of both Gleason score and grade group. More importantly, the bioinformatics analysis indicates that ZNF750 expression is positively correlated with better prognosis. Overall, our findings suggest that nuclear expression of ZNF750 may be a reliable prognostic biomarker for metastatic prostate cancer, which lays the foundation for the development of new biological therapies.

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LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A

Cited by 13 publications

References 34 publications

Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

Genetic Polymorphisms Associated with Prothrombin Time and Activated Partial Thromboplastin Time in Chinese Healthy Population

ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer

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