LINC00908 negatively regulates microRNA-483-5p to increase TSPYL5 expression and inhibit the development of prostate cancer

Фан, Ли; Li, Hai; Zhang, Yun

doi:10.1186/s12935-019-1073-x

Cited by 11 publications

(9 citation statements)

References 33 publications

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“… 7 Nevertheless, Fan et al found that LINC00908 inhibited prostate cancer progression by negatively regulating microRNA-483-5p and then elevate the expression of TSPYL5. 5 Obviously, the biological roles and mechanism of LINC00908 in human diseases including DLBCL are largely unknown. The current study aimed to investigate the exact roles and potential mechanism of LINC00908 in DLBCL.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that LINC00908 inhibited prostate cancer progression. 5 Nevertheless, other studies reported the oncogenic role of LINC00908 in hepatocellular carcinoma and colorectal cancer. 6 , 7 Obviously, the biological effects and underlying mechanism of LINC00908 in the development of main human malignant diseases, including DLBCL, remain elusive.…”

Section: Introductionmentioning

confidence: 99%

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LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Zeng¹,

Wei²,

Wei³

et al. 2021

CMAR

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Introduction Emerging evidence has revealed that long noncoding RNA (lncRNA) play important role in almost all kinds of human cancers. LINC00908 has been reported to be involved in the development of prostate cancer, colorectal cancer and gastric cancer which was functioned as an oncogene. However, the potential biology role and molecular mechanism of LINC00908 in diffuse large B-cell lymphoma are still unclear. Methods LINC00908 and miR-671-5p expression were evaluated in DLBCL tissues and cell lines using RT-qPCR. CCK-8 and transwell assay were used to analyze the in vitro role of LINC00908 in DLBCL progression. The xenograft model was used to explore the in vivo role of LINC00908 in DLBCL growth. The physical interaction between LINC00908 and miR-671-5p was confirmed using bioinformatics analysis and a dual luciferase assay, RIP and RNA pull down. Results The expression of LINC00908 was markedly up-regulated in diffuse large B-cell lymphoma tissues and cell lines, and the decreased expression of LINC00908 significantly inhibited diffuse large B-cell lymphoma cell proliferation and invasion. Then, we revealed that LINC00908 directly interacted with miR-671-5p, which was down-regulated in diffuse large B-cell lymphoma cells and highly expressed with LINC00908 knockdown. Moreover, luciferase reporter assays and RNA immunoprecipitation (RIP) assay further proved that miR-671-5p is a direct target of LINC00908 in diffuse large B-cell lymphoma cells. Rescue experiments were also performed, and we confirmed that LINC00908 acts as an oncogene role in diffuse large B-cell lymphoma through miR-671-5p. Finally, the influence of LINC00908 silence significantly inhibited diffuse large B-cell lymphoma growth in vivo. Conclusion LINC00908 promotes malignancy of diffuse large B-cell lymphoma through regulating miR-671-5p.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Zeng¹,

Wei²,

Wei³

et al. 2021

CMAR

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“…Linc00908 had been reported to be highly expressed in liver cancer and to interact with SOX4, thereby increasing its stability by inhibiting proteasomal degradation [42]. Linc00908 sponges with miR-483-5p in prostate cancer, and competitively reduces miR-483-5p targeting to TSPYL5 (testis-specific Y-encoded-like protein 5) to exert its anticancer function [43]. A recent study reported on a small 60 aa regulatory micropeptide of STAT3 (ASPRS) encoded by linc00908 in patients with triple negative breast cancer (TNBC) (Fig.…”

Section: Asprsmentioning

confidence: 99%

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Ye¹,

Zhang²,

Wang³

et al. 2020

Cancer Cell Int

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Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open reading frames of lncRNAs have micropeptide-coding potential. The resulting micropeptides have been shown to participate in N6-methyladenosine modification, tumor angiogenesis, cancer metabolism, and signal transduction. This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers.

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“…In recent years, emerging research has revealed that lncRNAs are crucial players in the occurrence and progression of diverse malignancies including PCa 7–8 . For example, LINC00908 expression is down‐regulated in PCa and inhibits the development of PCa 9 . lncRNA ZFAS1 and lncRNA UCA1 expression are up‐regulated in PCa, and they facilitate the growth and metastasis of PCa cells 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…development of PCa. 9 lncRNA ZFAS1 and lncRNA UCA1 expression are up-regulated in PCa, and they facilitate the growth and metastasis of PCa cells. 10,11 lncRNA small nucleolar RNA host gene 8 (SNHG8) plays an important role in promoting tumor growth and metastasis in esophageal squamous cell carcinoma, colorectal cancer and pancreatic cancer.…”

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confidence: 99%

Long non‐coding RNA SNHG8 promotes prostate cancer progression through repressing miR‐384 and up‐regulating HOXB7

Shi

Zhang

Song

et al. 2021

The Journal of Gene Medicine

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Background Multiple long non‐coding RNAs (lncRNAs) have been demonstrated to function as vital regulators in the progression of prostate cancer (PCa). In the present study, we aimed to probe the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in PCa progression. Methods A quantitative real‐time polymerase chain reaction and western blotting were utilized to measure SNHG8, microRNA‐384 (miR‐384) and homeobox B7 (HOXB7) expression. Call‐couting kit‐8 and bromodeoxyuridine experiments were employed to evaluate PCa cell proliferation. Transwell experiments were performed to detect PCa cell migration and invasion. Dual‐luciferase reporter experiments and RNA immunoprecipitation experiments were conducted to determine the targeting relationships among miR‐384, SNHG8 and HOXB7. Results SNHG8 was up‐regulated in PCa tissues and cells. Silencing of SNHG8 suppressed the proliferation, migration and invasion of PCa cells. SNHG8 functioned as a molecular sponge to repress miR‐384. The effects of SNHG8 knockdown on PCa cell proliferation, migration and invasion were counteracted by miR‐384 inhibition. HOXB7 was confirmed to be a target gene of miR‐384. SNHG8 knockdown repressed HOXB7 expression via targeting miR‐384. Conclusions SNHG8 promotes PCa cell proliferation, migration and invasion via decoying miR‐384 and up‐regulating HOXB7.

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LINC00908 negatively regulates microRNA-483-5p to increase TSPYL5 expression and inhibit the development of prostate cancer

Cited by 11 publications

References 33 publications

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Long non‐coding RNA SNHG8 promotes prostate cancer progression through repressing miR‐384 and up‐regulating HOXB7

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