LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR‐516b‐5p/Gli1 axis

Pan, Xiaohui; Tan, Jingxue; Tao, Tao; Zhang, Xiuwen; Weng, Yiping; Weng, Xiaokun; Xu, Jingwen; Li, Haibo; Jiang, Yuqing; Zhou, Dong; Shen, Yifei

doi:10.1111/cas.14913

Cited by 24 publications

(12 citation statements)

References 30 publications

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“…LncRNA LINC-PINT, as a tumor suppressor gene, targets miR-425-5p which targets Ptch1 of the Hh pathway to modulate laryngeal carcinoma cell stemness and chemoresistance. Several other regulatory networks comprising lncRNA, miRNA, and mRNA have been reported in the Hh-mediated cancer, including DIO3OS/miR-328/Hhip [ 139 ], GAS5/miR-378a-5p/Sufu [ 140 ], LIFR-AS1/miR-197-3p/Sufu [ 141 ], LOC101930370/miR-1471/Shh [ 142 ], TUG1/miR-132/Shh [ 143 ], LINC01510/miR-335/Shh [ 144 ], LINC01123/miR-516b-5p/Gli1 [ 145 ], NEAT1/miR-503/Smo [ 146 ] and MIRLET7BHG/miR-330-5p/Smo [ 147 ].…”

Section: Introductionmentioning

confidence: 99%

“…LncRNA HOTAIR overexpression is linked to worse prognosis in patients with renal cell carcinoma [ 153 ]. In osteosarcoma, elevated levels of LINC01123 expression are related with advanced pathological staging [ 145 ]. .Remarkably, miR-324-3p expression is inversely connected with nasopharyngeal carcinoma metastasis but favorably correlated with survival time [ 111 ].…”

Section: Introductionmentioning

confidence: 99%

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Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

Song

Sun

et al. 2022

Mol Cancer

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Cancer is a type of malignant affliction threatening human health worldwide; however, the molecular mechanism of cancer pathogenesis remains to be elusive. The oncogenic hedgehog (Hh) pathway is a highly evolutionarily conserved signaling pathway in which the hedgehog-Patched complex is internalized to cellular lysosomes for degradation, resulting in the release of Smoothened inhibition and producing downstream intracellular signals. Noncoding RNAs (ncRNAs) with diversified regulatory functions have the potency of controlling cellular processes. Compelling evidence reveals that Hh pathway, ncRNAs, or their crosstalk play complicated roles in the initiation, metastasis, apoptosis and drug resistance of cancer, allowing ncRNAs related to the Hh pathway to serve as clinical biomarkers for targeted cancer therapy. In this review, we attempt to depict the multiple patterns of ncRNAs in the progression of malignant tumors via interactions with the Hh crucial elements in order to better understand the complex regulatory mechanism, and focus on Hh associated ncRNA therapeutics aimed at boosting their application in the clinical setting.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

Song

Sun

et al. 2022

Mol Cancer

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“…Its abnormal expression is closely related to the occurrence and metastasis of tumors (Kornfeld and Bruning, 2014;Bartonicek et al, 2016). It has been confirmed that multiple lncRNAs can promote the occurrence and metastasis of osteosarcoma through competitive inhibition of miRNA expression (Pan et al, 2021;Zhou and Mu, 2021). Notably, lncRNAs can regulate the development and activation of a variety of immune cells (Atianand et al, 2017).…”

Section: Introductionmentioning

confidence: 96%

Immune-Related LncRNAs Affect the Prognosis of Osteosarcoma, Which Are Related to the Tumor Immune Microenvironment

Huang

Lin

Chen

et al. 2021

Front. Cell Dev. Biol.

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Background: Abnormal expression of lncRNA is closely related to the occurrence and metastasis of osteosarcoma. The tumor immune microenvironment (TIM) is considered to be an important factor affecting the prognosis and treatment of osteosarcoma. This study aims to explore the effect of immune-related lncRNAs (IRLs) on the prognosis of osteosarcoma and its relationship with the TIM.Methods: Ninety-five osteosarcoma samples from the TARGET database were included. Iterative LASSO regression and multivariate Cox regression analysis were used to screen the IRLs signature with the optimal AUC. The predict function was used to calculate the risk score and divide osteosarcoma into a high-risk group and low-risk group based on the optimal cut-off value of the risk score. The lncRNAs in IRLs signature that affect metastasis were screened for in vitro validation. Single sample gene set enrichment analysis (ssGSEA) and ESTIMATE algorithms were used to evaluate the role of TIM in the influence of IRLs on osteosarcoma prognosis.Results: Ten IRLs constituted the IRLs signature, with an AUC of 0.96. The recurrence and metastasis rates of osteosarcoma in the high-risk group were higher than those in the low-risk group. In vitro experiments showed that knockdown of lncRNA (AC006033.2) could increase the proliferation, migration, and invasion of osteosarcoma. ssGSEA and ESTIMATE results showed that the immune cell content and immune score in the low-risk group were generally higher than those in the high-risk group. In addition, the expression levels of immune escape-related genes were higher in the high-risk group.Conclusion: The IRLs signature is a reliable biomarker for the prognosis of osteosarcoma, and they alter the prognosis of osteosarcoma. In addition, IRLs signature and patient prognosis may be related to TIM in osteosarcoma. The higher the content of immune cells in the TIM of osteosarcoma, the lower the risk score of patients and the better the prognosis. The higher the expression of immune escape-related genes, the lower the risk score of patients and the better the prognosis.

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“…Recent researches had connected aberrant expression of lncRNAs with the development and progress of osteosarcoma. For example, the upregulated lncRNA LINC01123 in osteosarcoma functioned as a competing endogenous RNA via sponging miR-516b-5p, resulting in accelerated cell progression (Pan et al, 2021). Besides, lncRNAs could also act as prognostic biomarkers.…”

Section: Introductionmentioning

confidence: 99%

N6-Methyladenosine-Related lncRNAs Are Potential Prognostic Biomarkers and Correlated With Tumor Immune Microenvironment in Osteosarcoma

Zheng

Wei

et al. 2022

Front. Genet.

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N6-methyladenosine (m6A) and long non-coding RNAs (lncRNAs) play vital roles in the prognostic value and immune microenvironment of malignant tumors. Here, we constructed a m6A-related lncRNA signature in osteosarcoma samples from TCGA dataset and analyzed the association of the signature with tumor immune microenvironment. m6A-related lncRNAs were identified by performing Pearson’s correlation analysis and were used to construct a novel m6A-related lncRNA signature in osteosarcoma. Validation in testing and entire cohorts confirmed the satisfactory accuracy of the risk signature. Principal-component analysis verifies the grouping ability of the risk signature. Functional enrichment analyses connected immune with the risk signature based on the six m6A-related lncRNAs. When patients were separated into high- and low-risk group based on their risk scores, we found that patients in the high-risk group had lower stromal scores, immune scores, and ESTIMATE scores, while the tumor purity was higher in the high-risk group than that in the low-risk group. As for immune cell infiltration, the proportion of monocytes was significantly higher in the low-risk group than that in the high-risk group. Of the six lncRNAs, AC004812.2 was a protective factor in osteosarcoma and low expression of AC004812.2 predicted worse overall survival. Overexpression of AC004812.2 inhibited 143B cell proliferation and increased the expression levels of IGF2BP1 and YTHDF1. In all, our m6A-related lncRNA signature was a potential prognostic biomarker and correlated with tumor immune microenvironment and immune cell infiltration, and AC004812.2 might be an important regulator of m6A modification and a promising therapeutic target in osteosarcoma.

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LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR‐516b‐5p/Gli1 axis

Cited by 24 publications

References 30 publications

Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

Immune-Related LncRNAs Affect the Prognosis of Osteosarcoma, Which Are Related to the Tumor Immune Microenvironment

N6-Methyladenosine-Related lncRNAs Are Potential Prognostic Biomarkers and Correlated With Tumor Immune Microenvironment in Osteosarcoma

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