LINC01128 regulates the development of osteosarcoma by sponging miR‐299‐3p to mediate MMP2 expression and activating Wnt/β‐catenin signalling pathway

Yao, Qiang; Chen, Ting

doi:10.1111/jcmm.16046

Cited by 23 publications

(12 citation statements)

References 40 publications

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“…Osteosarcoma is the most common primary aggressive malignancies of the skeleton, and it occurs mainly in children and adolescents, in which distant metastasis still leads to a poor prognosis (Chow et al, 2020;Rojas et al, 2021). With a combination of neoadjuvant chemotherapy, surgery, chemotherapy, and biological therapy in the last few years, the 5-year survival rate for osteosarcoma patients has improved significantly, from 20% to 65-70% (Yao and Chen, 2020;Gazouli et al, 2021). However, due to the limited efficacy of current treatment strategies, nearly 30% of osteosarcoma patients are prone to metastasis or recurrence, with poor prognosis and low 5-year survival rates (Fan et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

Zhang

Liu

et al. 2021

Front. Genet.

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Osteosarcoma is a common malignant bone tumor with a propensity for drug resistance, recurrence, and metastasis. A growing number of studies have elucidated the dual role of pyroptosis in the development of cancer, which is a gasdermin-regulated novel inflammatory programmed cell death. However, the interaction between pyroptosis and the overall survival (OS) of osteosarcoma patients is poorly understood. This study aimed to construct a prognostic model based on pyroptosis-related genes to provide new insights into the prognosis of osteosarcoma patients. We identified 46 differentially expressed pyroptosis-associated genes between osteosarcoma tissues and normal control tissues. A total of six risk genes affecting the prognosis of osteosarcoma patients were screened to form a pyroptosis-related signature by univariate and LASSO regression analysis and verified using GSE21257 as a validation cohort. Combined with other clinical characteristics, including age, gender, and metastatic status, we found that the pyroptosis-related signature score, which we named “PRS-score,” was an independent prognostic factor for patients with osteosarcoma and that a low PRS-score indicated better OS and a lower risk of metastasis. The result of ssGSEA and ESTIMATE algorithms showed that a lower PRS-score indicated higher immune scores, higher levels of tumor infiltration by immune cells, more active immune function, and lower tumor purity. In summary, we developed and validated a pyroptosis-related signature for predicting the prognosis of osteosarcoma, which may contribute to early diagnosis and immunotherapy of osteosarcoma.

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Section: Introductionmentioning

confidence: 99%

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

Zhang

Liu

et al. 2021

Front. Genet.

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“…Previous studies have reported the indispensable roles of these two lncRNAs in tumor development and progression in different tumor types. 60 , 61 , 62 On the basis of the above-mentioned binding between miR-6077 and these two lncRNAs, as well as the functional experiments measuring cytotoxicity, cell-cycle percentage, and ferroptosis, we determined that GMDS-AS1 and LINC01128 sensitize LUAD cells to CDDP/PEM by negatively regulating the miR-6077-CDKN1A/KEAP1 axis.…”

Section: Discussionmentioning

confidence: 99%

miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways

Bi¹,

Liang²,

Zhao³

et al. 2022

Molecular Therapy - Nucleic Acids

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“…In addition, the expression of these genes is regulated by lncRNAs. For example, LINC01128 plays a regulatory role in cell invasion, migration, and proliferation through the LINC01128/miR-299-3p/MMP2 axis [ 44 ]. Based on the above analysis, we speculated that the lncRNAs Tcons_00021399 and Tcons_0009334 may play an essential role in regulating molecular mechanisms related to ECM recombination or spermatogenesis in goat testis.…”

Section: Discussionmentioning

confidence: 99%

Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats

Chen¹,

Miao²,

Xu³

et al. 2022

Anim Biosci

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Alterations of mRNAs and lncRNAs profiles associated with the extracellular Matrix matrix and spermatogenesis in goats ABSTRACTObjective: Spermatozoa is are produced in within the seminiferous tubules after sexual maturity. The expression levels of mRNAs and lncRNAs in testicular tissues were are different at different each stages of testicular development. The expression of mRNA and lncRNA wasand are closely related to the formation of the extracellular matrix and spermatogenesis. Therefore, it is necessarwe set outy to study the expression of lncRNAs and mRNAs in during the different developmental stages of the goat testis development.Methods: We constructed 12 RNA libraries from using testiculartestis tissues of from goats aged 3, 6, and 12 months, and studied the functions of mRNAs and lncRNAs by using the Gene Ontogeny (GO) and Kyoto Encyclopedia of Genesome and Genomics Genomes (KEGG) databases. The rRelationships between differentially expressed genes (DEGs) was were analyzed by lncRNA-mRNA co-expression network and protein-protein interaction network (PPI). Finally, the protein expression levels of Matrix matrix metalloproteinase 2 (MMP2), insulin-like growth factor 2 (IGF2), and insulin-like growth factor-binding protein 6 (IGFBP6) were detected by western wWestern blotting. Results:We found 23, 8, and 135 differentially expressed lncRNAss and 161, 12, and 665 differentially expressed mRNAss that were identified between 3 VS vs. 6, 6 VS vs. 12, and 3 VS vs. 12 months, respectively. GO, KEGG, and PPI analysis analyses showed that the differential genes were mainly related to the extracellular Matrixmatrix. Moreover, MMP2 was a hub gene and co-expressed with the lncRNAs TCONS-0002139 and TCONS-00093342.

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LINC01128 regulates the development of osteosarcoma by sponging miR‐299‐3p to mediate MMP2 expression and activating Wnt/β‐catenin signalling pathway

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 23 publications

References 40 publications

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways

Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats

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