LINC01133 Hampers the Development of Gastric Cancer Through Increasing Somatostatin via Binding to microRNA-576-5p

Zhang, Leiyi; Pan, Ke; Zuo, Zhongkun; Ye, Fei; Cao, Ding; Yu, Pei; Tang, Tao; Li, Xiaojing; Zhou, Shiwei; Duan, Lunxi

doi:10.2217/epi-2020-0377

Cited by 8 publications

(11 citation statements)

References 26 publications

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“…quantified the level of LINC01133 in 200 cases of gastric cancer and paired adjacent tissues using qPCR and found a significantly lower expression level of LINC01133 in gastric cancer tissues compared to that in the paired tissues ( 26 ). This result was also consistent with that of another study that analyzed a cohort of 254 pairs of gastric cancer and adjacent tissues ( 16 ). In both these studies, LINC01133 acted as a tumor suppressor via the ceRNA mechanism.…”

Section: Mechanisms Regulating the Expression Level Of Linc01133supporting

confidence: 92%

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New Sights Into Long Non-Coding RNA LINC01133 in Cancer

Jiang

Zhang

et al. 2022

Front. Oncol.

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LINC01133 is a long intergenic non-coding RNA that regulates malignancy in several cancers, including those of the digestive, female reproductive, respiratory, and urinary system. LINC01133 is an extensively studied lncRNA that is highly conserved, and its relatively stable expression is essential for its robust biological function. Its expression is highly tissue-specific with a distinct subcellular localization. It functions as an oncogene or a tumor suppressor gene in different cancers via multiple mechanisms, such as those that involve competing with endogenous RNA and binding to RNA-binding proteins or DNA. Moreover, the secretion and transportation of LINC01133 by extracellular vesicles in the tumor micro-environment is regulated by other cells in the tumor micro-environment. To date, two mechanisms, an increase in copy number and regulation of transcription elements, have been found to regulate LINC01133 expression. Clinically, LINC01133 is an ideal marker for cancer prognosis and a potential therapeutic target in cancer treatment regimes. In this review, we aimed to summarize the aforementioned information as well as posit future directions for LINC01133 research.

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Section: Mechanisms Regulating the Expression Level Of Linc01133supporting

confidence: 92%

“…LINC01133 is located in both the nucleus and cytoplasm, and this subcellular localization depends on the type of cancer. For example, LINC01133 tends to localize in both the nucleus and cytoplasm in ovarian cancer ( 15 ), and it tends to localize in the cytoplasm rather than in the nucleus in gastric cancers ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

New Sights Into Long Non-Coding RNA LINC01133 in Cancer

Jiang

Zhang

et al. 2022

Front. Oncol.

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“…Disparate functions of LINC01133 depending on cancer types have been reported. LINC01133 hampers gastric and bladder cancer progression via somatostatin upregulation and WNT signaling inactivation, respectively [203,204]. Consistently, by suppressing SRY-box transcription factor 4 (SOX4) expression, LINC01133 is capable of inhibiting metastasis in breast cancer [205].…”

Section: Linc01133mentioning

confidence: 92%

Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers

Yun

Choi

Son

et al. 2022

IJMS

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Circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) are differentially expressed in gastrointestinal cancers. These noncoding RNAs (ncRNAs) regulate a variety of cellular activities by physically interacting with microRNAs and proteins and altering their activity. It has also been suggested that exosomes encapsulate circRNAs and lncRNAs in cancer cells. Exosomes are then discharged into the extracellular environment, where they are taken up by other cells. As a result, exosomal ncRNA cargo is critical for cell–cell communication within the cancer microenvironment. Exosomal ncRNAs can regulate a range of events, such as angiogenesis, metastasis, immune evasion, drug resistance, and epithelial-to-mesenchymal transition. To set the groundwork for developing novel therapeutic strategies against gastrointestinal malignancies, a thorough understanding of circRNAs and lncRNAs is required. In this review, we discuss the function and intrinsic features of oncogenic circRNAs and lncRNAs that are enriched within exosomes.

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“…Up-regulation miR-576-5p or inhibition of SST has upturned the biological effects of LINC01133 in gastric cancer cells. Thus, LINC01133 up-regulation can suppress development of gastric cancer through decreasing expression of miR-576-5p and enhancing SST levels [ 22 ].…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

A review on the role of LINC01133 in cancers

et al. 2022

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Long Intergenic Non-Protein Coding RNA 1133 (LINC01133) is a long non-coding RNA (lncRNA) which interacts with miR-106a-3p, miR-576-5p, miR-495-3p, miR-205, miR-199a-5p, miR-4784, miR-30a-5p, miR-199a, miR-30b-5p, miR-216a -5p and miR-422a, thus increasing expression of mRNA targets of these miRNAs. LINC01133 can affect cancer metastasis through regulation of epithelial-mesenchymal transition program. Dysregulation of this lncRNA has been repeatedly detected in the process of tumorigenesis. In this review, we summarize the results of various studies that reported dysregulation of LINC01133 in different samples and described the role of this lncRNA as a marker for these disorders.

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LINC01133 Hampers the Development of Gastric Cancer Through Increasing Somatostatin via Binding to microRNA-576-5p

Cited by 8 publications

References 26 publications

New Sights Into Long Non-Coding RNA LINC01133 in Cancer

New Sights Into Long Non-Coding RNA LINC01133 in Cancer

Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers

A review on the role of LINC01133 in cancers

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