LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis

Li, Xiaoshi

doi:10.1155/2022/2434938

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…At present, none of the new blood markers for the diagnosis of breast cancer, such as circulating tumor cells (17) and microRNA (18,19), has reached the standard of clinical routine practice, while circulating immune cells are considered a potential key breakthrough. This study found that the proportion of CD4 + Tn cells was decreased in patients with breast cancer, while the absolute number and proportion of CD4 + CD57 + T and CD4 + PD-1 + T cells were significantly increased compared with those in patients with benign tumors.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and postoperative dynamic changes in circulating CD4+ helper T lymphocytes in patients with breast cancer

Zhang

Wang

et al. 2023

Front. Oncol.

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IntroductionCirculating CD4+ helper T cell (Th) subsets provide potentially important information on disease progression in several cancers. In this study, we explored the characteristics and postoperative dynamic changes in circulating CD4+Th subsets in patients with breast cancer.MethodsCirculating CD4+Th subsets, including CD4+ naive T cells (Tn), CD4+ central memory T cells (Tcm), CD4+ effector memory T cells (Tem), CD4+CD57+T, and CD4+PD-1+T, were detected with multiparameter flow cytometry. T-test and Wilcoxon rank-sum test were used to compare differences between groups for normally and non-normally distributed continuous variables, respectively. Postoperative dynamic changes in CD4+Th subsets were assessed using the paired-sample rank-sum test.ResultsSeventy-five patients with invasive breast cancer and fifty-three patients with benign breast tumors were enrolled. Compared with that in patients with benign tumors, the proportion of CD4+Tn in patients with breast cancer patients decreased, whereas the proportion and absolute number of CD4+CD57+T and CD4+PD-1+T increased. Moreover, the proportion of CD4+PD-1+T was correlated with the clinicopathology of breast cancer. After tumor resection, the proportion and absolute number of CD4+Tcm significantly decreased, while those of CD4+Tem significantly increased, compared with preoperative values. Tumor resection caused significant changes in the proportion and absolute number of CD4+CD57+T and CD4+PD-1+ T, both of which showed significant decreases.DiscussionWe found significant changes in circulating CD4+Th subsets in patients with breast cancer. Additionally, complete tumor resection can benefit the patient as it balances the patient’s immunosuppression and immune stress and improves the immune exhaustion and immunosenescence states.

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Section: Discussionmentioning

confidence: 99%

Characteristics and postoperative dynamic changes in circulating CD4+ helper T lymphocytes in patients with breast cancer

Zhang

Wang

et al. 2023

Front. Oncol.

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“…A study by Li investigated the role of microRNAs (miRNAs) in breast cancer, specifically focusing on miR-452-5p. They found this miRNA to be upregulated in breast cancer tissues, suggesting it plays a role in tumor development [30]. Building on the understanding of miR-452-5p's anti-apoptotic role in colorectal cancer, this study by Lin et al delves deeper into the complex mechanisms by which miRNAs regulate apoptosis.…”

Section: Cerna Network and Apoptosismentioning

confidence: 91%

Integrated Bioinformatics Analysis Reveals ceRNA Triplet Related to Apoptosis in Gastric Cancer

Nath,

Natarajan

2024

MEDIN

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Apoptosis is a form of programmed cell death and evading the apoptosis is a milestone in gastric cancer (GC) tumorigenesis. Various RNAs such as miRNA (microRNA), mRNA (messenger RNA), lncRNA (long non-coding RNA), circRNA (circular RNA), play crucial roles in the apoptosis mechanism. In this present study, we aimed to understand the role played by these RNAs in apoptosis in GC. We constructed a ceRNA (competitive endogenous RNA) network using the expression profiles obtained from SRA (Sequence Read Archive) and GEO (Gene Expression Omnibus) datasets. After network construction, the differentially expressed mRNAs were used for gene prioritization. The prioritized genes and the RNAs interacting with them were analyzed to study their role in GC apoptosis. Then, we performed functional and pathway analysis to understand the role played by these genes in gastric cancer. This resulted in 37 miRNA-mRNA interactions, one miRNA-lncRNA interaction, and 17 miRNA-circRNA interactions. The binding site analysis resulted in 10 miRNAs that share common MRE (miRNA Response Elements) among mRNA, lncRNAs, circRNA. Besides, we found 33 miRNA-mRNA-circRNA and two miRNA-mRNA-lncRNA valid interactions. Integration of multiple omics datasets revealed dysregulated genes, including IGF1, MME, CCND2, CDH2, and COL1A1, implicated in GC apoptosis. Functional enrichment analysis highlighted pathways related to apoptosis, with CCND2 emerging as a key player. The integrative methodology has revealed a new potential diagnostic biomarker for the regulation of gastric cancer (GC) apoptosis: the CCND2-miR-141-3p-hsa_circ_0008035 ceRNA triplet. This discovery offers fresh perspectives into the intricate regulatory pathways governing gene expression in GC, promising significant insights into its pathology.

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“…MicroRNA (miRNA) is a kind of cellular endogenous non-coding RNA molecule with the function of regulating the translation of protein, which is about 22 nucleotides long 10 , 11 . It was reported that miR-452-5p exerted different effects in different types of tumors 12 , 13 . The regulatory role of miR-452-5p in NSCLC remains unclear, and if miR-452-5p could affect the EMT process of NSCLC cells has not been reported.…”

Section: Introductionmentioning

confidence: 99%

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

Zhuang¹,

Fan²,

Zhu³

et al. 2023

J. Cancer

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Background: Non-small cell lung cancer (NSCLC) is a common malignant tumor, and it is characterized by high mortality. and Moesin (MSN) have been proved to be related with regulation of tumors. If miR-452-5p could regulate NSCLC through targeting MSN remain unclear. Methods: TargetScan data and GEPIA databases were used to predict binding site and analyze gene expression, respectively. EdU staining, wound healing, and Transwell assays were performed to measure cell proliferation, migration, and invasion, respectively. Results: The binding site between miR-452-5p and MSN was predicted and validated. Overexpression of miR-452-5p cell lines were constructed, and miR-452-5p mimics markedly inhibited the migration, invasion, and proliferation ability of both H322 and A549 cells, but these effects of miR-452-5p were reversed by pcDNA-MSN. pcDNA-MSN significantly reversed the influence of miR-452-5p mimics on the EMT related proteins expression in H322 and A549 cell lines by decreasing E-cadherin and increasing N-cadherin. Significant higher expression of MSN in lung adenocarcinoma and lung squamous cell carcinoma was observed through GEPIA and TCGA data base analysis. Higher expression of MSN is positively correlated with advanced lung cancer and suggests poor prognosis. Conclusions: We demonstrated that miR-452-5p modulated the cell proliferation, migration, invasion, and EMT process of H322 and A549 cell lines through targeting MSN. This research might provide a novel prevention and treatment target for NSCLC.

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LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis

Cited by 5 publications

References 45 publications

Characteristics and postoperative dynamic changes in circulating CD4+ helper T lymphocytes in patients with breast cancer

Characteristics and postoperative dynamic changes in circulating CD4+ helper T lymphocytes in patients with breast cancer

Integrated Bioinformatics Analysis Reveals ceRNA Triplet Related to Apoptosis in Gastric Cancer

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

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