LINC01419 Promotes the Proliferation of Hepatoma Cells by Recruiting XRCC5 and Regulating Its Phosphorylation to Repair DNA Damage

Liu, Pan; Zhang, Xu; Fu, Qiang; Liu, ChuanJiang; Luo, Qiankun; Yu, Pengfei; Chen, Song; Zhang, Hongwei; Qin, Tao

doi:10.1155/2022/9313680

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…In normal cells, DNA damage repair maintains the genomic integrity. In tumour cells, however, the continuous activation of DNA damage repair signalling plays a vital role in the failure of chemotherapy in cancer 77–80 . The microprotein DDUP, which is encoded by lncRNA CTBP1‐DT, exhibited a significant increase in cisplatin‐resistant ovarian cancer cells.…”

Section: Mechanisms Underlying Cancer Drug Resistancementioning

confidence: 99%

“…In tumour cells, however, the continuous activation of DNA damage repair signalling plays a vital role in the failure of chemotherapy in cancer. 77 , 78 , 79 , 80 The microprotein DDUP, which is encoded by lncRNA CTBP1‐DT, exhibited a significant increase in cisplatin‐resistant ovarian cancer cells. Furthermore, there was an inverse correlation between the expression of DDUP and the response to cisplatin‐based therapy.…”

Section: Mechanisms Underlying Cancer Drug Resistancementioning

confidence: 99%

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New insights into the interaction between m6A modification and lncRNA in cancer drug resistance

Jin,

Fan

2023

Cell Proliferation

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Drug resistance is perhaps the greatest obstacle in improving outcomes for cancer patients, leading to recurrence, progression and metastasis of various cancers. Exploring the underlying mechanism worth further study. N6‐methyladenosine (m6A) is the most common RNA modification found in eukaryotes, playing a vital role in RNA translation, transportation, stability, degradation, splicing and processing. Long noncoding RNA (lncRNA) refers to a group of transcripts that are longer than 200 nucleotides (nt) and typically lack the ability to code for proteins. LncRNA has been identified to play a significant role in regulating multiple aspects of tumour development and progression, including proliferation, metastasis, metabolism, and resistance to treatment. In recent years, a growing body of evidence has emerged, highlighting the crucial role of the interplay between m6A modification and lncRNA in determining the sensitivity of cancer cells to chemotherapeutic agents. In this review, we focus on the recent advancements in the interaction between m6A modification and lncRNA in the modulation of cancer drug resistance. Additionally, we aim to explore the underlying mechanisms involved in this process. The objective of this review is to provide valuable insights and suggest potential future directions for the reversal of chemoresistance in cancer.

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Section: Mechanisms Underlying Cancer Drug Resistancementioning

confidence: 99%

Section: Mechanisms Underlying Cancer Drug Resistancementioning

confidence: 99%

New insights into the interaction between m6A modification and lncRNA in cancer drug resistance

Jin,

Fan

2023

Cell Proliferation

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Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Liu

et al. 2022

BMC Neurosci

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Background Dysregulation of long noncoding RNA (lncRNA) expression is related to aging and age-associated neurodegenerative diseases, and the lncRNA expression profile in the aging hippocampus is not well characterized. In the present investigation, the changed mRNAs and lncRNAs were confirmed via deep RNA sequencing. GO and KEGG pathway analyses were conducted to investigate the principal roles of the clearly dysregulated mRNAs and lncRNAs. Subsequently, through the prediction of miRNAs via which mRNAs and lncRNAs bind together, a competitive endogenous RNA network was constructed. Results A total of 447 lncRNAs and 182 mRNAs were upregulated, and 385 lncRNAs and 144 mRNAs were downregulated. Real-time reverse transcription-polymerase chain reaction validated the reliability of mRNA and lncRNA sequencing. KEGG pathway and GO analyses revealed that differentially expressed (DE) mRNAs were associated with cell adhesion molecules (CAMs), the p53 signaling pathway (SP), phagosomes, PPAR SP and ECM—receptor interactions. KEGG pathway and GO analyses showed that the target genes of the DE lncRNAs were related to cellular senescence, the p53 signaling pathway, leukocyte transendothelial migration and tyrosine metabolism. Coexpression analyses showed that 561 DE lncRNAs were associated with DE mRNAs. A total of 58 lncRNA–miRNA–mRNA target pairs were confirmed in this lncRNA‒miRNA‒mRNA network, comprising 10 mRNAs, 13 miRNAs and 38 lncRNAs. Conclusions We found specific lncRNAs and mRNAs in the hippocampus of natural aging model rats, as well as abnormal regulatory ceRNA networks. Our outcomes help explain the pathogenesis of brain aging and provide direction for further research.

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LINC01419 Promotes the Proliferation of Hepatoma Cells by Recruiting XRCC5 and Regulating Its Phosphorylation to Repair DNA Damage

Cited by 2 publications

References 32 publications

New insights into the interaction between m6A modification and lncRNA in cancer drug resistance

New insights into the interaction between m6A modification and lncRNA in cancer drug resistance

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

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