LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3 axis

Cai, Qixuan; Zhao, Xin; Wang, Yanbing; Li, Shuai; Wang, Jincheng; Xin, Zhuoyuan; Фан, Ли

doi:10.1016/j.cellsig.2021.109985

Cited by 27 publications

(22 citation statements)

References 37 publications

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“…LINC01614 is located on human chromosome 2q35, so far, many studies have shown that it promotes the progression of different cancers, such as lung cancer (Liu et al, 2018), breast cancer (Vishnubalaji et al, 2019), glioma (Wang Y et al, 2020) and osteosarcoma (Cai et al, 2021). Similarly, Chen et al' work addresses part of the same issues and reports similar results as those presented here.…”

Section: Discussionsupporting

confidence: 81%

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Zhou

Chen

et al. 2021

Front. Genet.

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Background: Long non-coding RNAs (lncRNAs) reportedly play important roles in biomarker and tumorigenesis of gastric cancer (GC). This study aimed to determine the potential application of prognostic lncRNA signature and identified the role of LINC01614 in carcinogenesis in GC.Material and Methods: Data accessed from the Cancer Genome Atlas database was used to construct a lncRNA signature. Joint effect analysis of the signature and clinical parameters was performed to verify the clinical value of the signature. Co-expression analysis was conducted for prognostic lncRNAs and protein-coding genes. Moreover, the relative expression of LINC01614 was validated in GC tissues and cell lines. In vitro and in vivo experiments were conducted to analyze the biological functions of the newly identified gene in GC cells.Results: A seven-lncRNA (LINC01614, LINC01537, LINC01210, OVAAL, LINC01446, CYMP-AS1, and SCAT8) signature was identified as a promising prognostic signature in GC. Results indicated that the seven-lncRNA was involved in tumorigenesis and progression pathways. LINC01614 expression was identified and found to be upregulated in GC tissues and cells. The study findings revealed that LINC01614 promoted cell proliferation, migration, invasion, and epithelial-mesenchymal transition. Knockdown of LINC01614 arrested cell cycle distribution at the G2/M phase. Further, LINC01614 also promoted tumor growth in vivo.Conclusion: We developed an independent seven-lncRNA biomarker for prognostic prediction and identified LINC01614 as an oncogenic lncRNA in GC.

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Section: Discussionsupporting

confidence: 81%

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Zhou

Chen

et al. 2021

Front. Genet.

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“…3, ac023024.1, ac124 067.4, ZBTB40-iT1 and linc00092) in the PFS signature. linc00449 (34), linc01614 (35)(36)(37)(38)(39), linc00460 (40)(41)(42)(43)(44), PVT1 (24,26,(45)(46)(47)(48)(49), linc01094 (50)(51)(52)(53)(54)(55), linc01977 (56), ZBTB40-iT1 (57) and linc00092 (58) were previously reported to regulate the biological behavior or serve as prognostic tumor biomarkers in various cancer types. except for these lncrnas mentioned above, the other lncrnas included in the signatures have remained largely unexplored, which will be the focus of future studies by our group.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 12 lncRNAs (AC026368.1, CFAP61-AS1, AC090772.1, LINC00449, AC005165.1, LINC01614, AL356215.1, REPIN1-AS1, LASTR, LINC00460, AC015712.1 and PVT1) were included in the OS signature and 13 lncRNAs (AL163953.1, AL356417.2, POLH-AS1, LINC01094, AP002784.1, AL031985.3, LINC01977, LASTR, AC068790.3, AC023024.1, AC124067.4, ZBTB40-IT1 and LINC00092) in the PFS signature. LINC00449 ( 34 ), LINC01614 ( 35 – 39 ), LINC00460 ( 40 – 44 ), PVT1 ( 24 , 26 , 45 – 49 ), LINC01094 ( 50 – 55 ), LINC01977 ( 56 ), ZBTB40-IT1 ( 57 ) and LINC00092 ( 58 ) were previously reported to regulate the biological behavior or serve as prognostic tumor biomarkers in various cancer types. Except for these lncRNAs mentioned above, the other lncRNAs included in the signatures have remained largely unexplored, which will be the focus of future studies by our group.…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma

et al. 2022

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Ferroptosis is a form of programmed cell death that participates in diverse physiological processes. increasing evidence suggests that long noncoding rnas (lncrnas) regulate ferroptosis in tumors, including stomach adenocarcinoma (STad). in the present study, rna-sequencing data from The cancer Genome atlas database and ferroptosis-related markers from the Ferrdb data resource were analyzed to select differentially expressed lncrnas. univariate and multivariate cox regression analyses were performed on these differentially expressed lncrnas to screen 12 lncrnas linked with overall survival (oS) and 13 associated with progression-free survival (PFS). Subsequently, two signatures for predicting oS and PFS were established based on these lncrnas. Kaplan-Meier analyses indicated that the high-risk group of patients with STad had relatively poor prognosis. The areas under the receiver operating characteristic curves of the two signatures indicated their excellent efficacy in predicting STAD prognosis. in addition, the effect of the lncrna laSTr on proliferation and migration in gastric cancer was confirmed and the relationship between laSTr and ferroptosis was initially explored through experiments. These results provide potential novel targets for tumor treatment and promote personalized medicine.

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“…In glioma, Wang et al., found that SP1-mediated upregulation of LINC01614 functions a ceRNA for miR-383 to facilitate tumor progression via regulation of ADAM12 ( 35 ). Recently, Cai et al., showed that LINC01614 promoted osteosarcoma progression via the miR-520a-3p/sorting nexin 3 axis ( 36 ). Our in vitro studies showed that silence of LINC01614 attenuated the progression of gastric cancer cells and enhanced the chemosensitivity of gastric cancer cells to cisplatin, suggesting that LINC01614 may serve as an oncogenic RNA in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Revealing the Role of lncRNA CCDC144NL-AS1 and LINC01614 in Gastric Cancer via Integrative Bioinformatics Analysis and Experimental Validation

et al. 2022

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Long non-coding RNAs (lncRNAs) are key regulators in the pathophysiology of gastric cancer, and lncRNAs have been regarded as potential biomarkers and therapeutic targets for gastric cancer. The present study performed the WGCNA analysis of the GSE70880 dataset and aimed to identify novel lncRNAs associated with gastric cancer progression. Based on the WGCNA, the lncRNAs and mRNA co-expression network were constructed. A total of four modules were identified and the eigengenes in different modules were involved in various key signaling pathways. Furthermore, the co-expression networks were constructed between the lncRNAs and mRNA; this leads to the identification of 6 modules, which participated in various cellular pathways. The survival analysis showed that high expression of CCDC144NL antisense RNA 1 (CCDC144NL-AS1) and LINC01614 was positively correlated with the poor prognosis of patients with gastric cancer. The in vitro validation results showed that CCDC144NL-AS1 and LINC01614 were both up-regulated in the gastric cancer cells. Silence of CCDC144NL-AS1 and LINC01614 both significantly suppressed the cell proliferation and migration of gastric cancer cells, and also promoted the chemosensitivity of gastric cancer cells to 5-fluorouracil. Collectively, our results suggested that the newly identified two lncRNAs (CCDC144NL-AS1 and LINC01614) may act as oncogenes in gastric cancer.

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LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3 axis

Cited by 27 publications

References 37 publications

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma

Revealing the Role of lncRNA CCDC144NL-AS1 and LINC01614 in Gastric Cancer via Integrative Bioinformatics Analysis and Experimental Validation

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