LINC02381-ceRNA exerts its oncogenic effect through regulation of IGF1R signaling pathway in glioma

Nemati, Hossein; Fakhre-Taha, Masoumeh; Javanmard, Amir‐Reza; Jahanbakhshi, Amin; Mowla, Seyed Javad; Soltani, Bahram Mohammad

doi:10.1007/s11060-022-03992-y

Cited by 5 publications

(2 citation statements)

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“…Although some differentially expressed genes were shared between T2D and control samples ( Figure 3 B), 181 up- and 179 down-regulated genes were differentially regulated specifically in T2D compared to the control samples, including 35 up- and 22 down-regulated lncRNA genes ( Supplementary Table S6 ). Among these up-regulated lncRNA genes, only the following nine have been previously studied: (1) ENSG00000232855 (novel transcript) [ 75 ]; (2) ENSG00000272512 (novel transcript) [ 76 ]; (3) KCNJ2 antisense RNA 1 (KCNJ2-AS1) [ 77 , 78 , 79 ]; (4) KLHDC7B divergent transcript (KLHDC7B-DT) [ 80 , 81 , 82 ]; (5) long intergenic non-protein-coding RNA 2015 (LINC02015) [ 83 , 84 ]; (6) long intergenic non-protein-coding RNA 2381 (LINC02381) [ 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]; (7) long intergenic non-protein-coding RNA 2541 (LINC02541) [ 94 ]; (8) serpin family B member 9 pseudogene 1 (SERPINB9P1) [ 95 , 96 , 97 ]; and (9) USP30 antisense RNA 1 (USP30-AS1) [ 98 , 99 , 100 ]. However, only the functions of the lncRNA genes LINC02381 and USP30_AS1 are known, with the former known to bind transcription factors [ 85 ], RNA-binding proteins [ 86 ], and miRNAs [ 87 , 88 , 89 , 90 , 91 , 92 , 93 ]; while USP30-AS1 acts as a miRNA sponge [ 98 , 99 ] and is involved in the cis-regulation of the nearby protein-coding genes USP30 and ANKRD13A [ 100 ].…”

Section: Resultsmentioning

confidence: 99%

“…(2) ENSG00000272512 (novel transcript) [76]; (3) KCNJ2 antisense RNA 1 (KCNJ2-AS1) [77][78][79]; (4) KLHDC7B divergent transcript (KLHDC7B-DT) [80][81][82]; (5) long intergenic non-proteincoding RNA 2015 (LINC02015) [83,84]; (6) long intergenic non-protein-coding RNA 2381 (LINC02381) [85][86][87][88][89][90][91][92][93]; (7) long intergenic non-protein-coding RNA 2541 (LINC02541) [94]; (8) serpin family B member 9 pseudogene 1 (SERPINB9P1) [95][96][97]; and (9) USP30 antisense RNA 1 (USP30-AS1) [98][99][100]. However, only the functions of the lncRNA genes LINC02381 and USP30_AS1 are known, with the former known to bind transcription factors [85], RNA-binding proteins [86], and miRNAs [87][88][89][90][91][92][93]; while USP30-AS1 acts as a miRNA sponge [98,99] and is involved in the cis-regulation of the nearby protein-coding genes USP30 and ANKRD13A [100]. Neither LINC02381 nor USP30-AS1 are known to be involved in T2D, which calls for further investigation.…”

Section: Many Lncrnas Are Differentially Expressed In Cultured Macrop...mentioning

confidence: 99%

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T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes

Distefano

Ilieva

Madsen

et al. 2023

ncRNA

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Type II diabetes (T2D) is a growing health problem worldwide due to increased levels of obesity and can lead to other life-threatening diseases, such as cardiovascular and kidney diseases. As the number of individuals diagnosed with T2D rises, there is an urgent need to understand the pathogenesis of the disease in order to prevent further harm to the body caused by elevated blood glucose levels. Recent advances in long non-coding RNA (lncRNA) research may provide insights into the pathogenesis of T2D. Although lncRNAs can be readily detected in RNA sequencing (RNA-seq) data, most published datasets of T2D patients compared to healthy donors focus only on protein-coding genes, leaving lncRNAs to be undiscovered and understudied. To address this knowledge gap, we performed a secondary analysis of published RNA-seq data of T2D patients and of patients with related health complications to systematically analyze the expression changes of lncRNA genes in relation to the protein-coding genes. Since immune cells play important roles in T2D, we conducted loss-of-function experiments to provide functional data on the T2D-related lncRNA USP30-AS1, using an in vitro model of pro-inflammatory macrophage activation. To facilitate lncRNA research in T2D, we developed a web application, T2DB, to provide a one-stop-shop for expression profiling of protein-coding and lncRNA genes in T2D patients compared to healthy donors or subjects without T2D.

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