Lincomycin Hydrochloride: Clinical and Laboratory Studies

Trial of Phenoxymethylpenicillin, Phenethicillin, and Lincomycin in Treatment of Staphylococcal Sepsis in a Casualty Department

“…We encountered a much higher incidence of diarrhoea in patients receiving lincomycin than the 10-20% described by other workers (Harnecker et al, 1963;Geddes et al, 1964). It is known that taking a meal shortly before lincomycin can halve the peak serum levels (McCall et al, 1967).…”

Lincomycin in the treatment of penicillin-resistant staphylococcal infections in children.

“…Previous reports have described isolated gastro-intestinal disturbances, pruritus, and mild aches in the limbs during treatment with lincomycin. Loose stools, which have occurred mostly when the drug has been taken by mouth, have occasionally necessitated cessation of therapy (Geddes et al, 1964;MacLeod et al, 1964;Holloway et al, 1963;Harnecker, Contreras, Gilabert, and Ubilla, 1963).…”

“…The studies of various workers suggest that very few strains of staphylococcus are naturally resistant to lincomycin and that resistance develops less readily in vivo to lincomycin than it does to erythromycin (Lewis et al, 1962;Clapper, Meade, and Stewart, 1964;Geddes et al, 1964). Out of a total of 510 cultures of staphylococci routinely tested for sensitivity to lincomycin in vitro but isolated from patients who were not receiving lincomycin, only 2 were resistant.…”

In-vitro Comparison of Erythromycin, Lincomycin, and Clindamycin

“…Erythromycin and lincomycin have been compared in several previous studies, with the conclusion, usually, that erythromycin is slightly more active and is thus the more useful drug, except possibly in the treatment of osteomyelitis, for which lincomycin is preferred, but on the basis of pharmacological rather than microbiological properties (Barber and Waterworth, 1964;Geddes, Sleet, and Murdoch, 1964;Mc-Millan, McRae, and McDougall, 1967;Sanders, 1969).…”