Line bisection judgments implicate right parietal cortex and cerebellum as assessed by fMRI

Fink, Gereon R.; Marshall, John C.; Shah, N. Jon; Weiss, Peter H.; Halligan, Peter W.; Grosse-Ruyken, M.-L.; Ziemons, K.; Zilles, Karl; Freund, Hans‐Joachim

doi:10.1212/wnl.54.6.1324

Cited by 360 publications

(215 citation statements)

References 19 publications

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“…The pattern of activation in our control group (of 'typical' subjects) is in line with findings of a previous study by Fink and colleagues who used a similar paradigm (Landmark task) in healthy volunteers (Fink et al, 2000(Fink et al, , 2001. During the Landmark task, these authors found activation predominantly in the right superior and inferior parietal cortex, as well as prefrontal cortex and anterior cingulate.…”

Section: Intrahemispheric Pattern Of Activation For Spatial Attentionsupporting

confidence: 91%

Atypical Hemispheric Dominance for Attention: Functional MRI Topography

Flöel

Jansen

Deppe

et al. 2005

J Cereb Blood Flow Metab

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The right hemisphere is predominantly involved in tasks associated with spatial attention. However, left hemispheric dominance for spatial attention can be found in healthy individuals, and both spatial attention and language can be lateralized to the same hemisphere. Little is known about the underlying regional distribution of neural activation in these 'atypical' individuals. Previously a large number of healthy subjects were screened for hemispheric dominance of visuospatial attention and language, using functional Doppler ultrasonography. From this group, subjects were chosen who were 'atypical' for hemispheric dominance of visuospatial attention and language, and their pattern of brain activation was studied with functional magnetic resonance imaging during a task probing spatial attention. Right-handed subjects with the 'typical' pattern of brain organization served as control subjects. It was found that subjects with an inverted lateralization of language and spatial attention (language right, attention left) recruited left-hemispheric areas in the attention task, homotopic to those recruited by control subjects in the right hemisphere. Subjects with lateralization of both language and attention to the right hemisphere activated an attentional network in the right hemisphere that was comparable to control subjects. The present findings suggest that not the hemispheric side, but the intrahemispheric pattern of activation is the distinct feature for the neural processes underlying language and attention.

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Section: Intrahemispheric Pattern Of Activation For Spatial Attentionsupporting

confidence: 91%

Atypical Hemispheric Dominance for Attention: Functional MRI Topography

Flöel

Jansen

Deppe

et al. 2005

J Cereb Blood Flow Metab

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“…This area has previously been implicated in monitoring sensory conflicts (Fink et al, 1999). Taken together, both the behavioural and the functional imaging data thus suggest that the interference of external colour with synaesthetic colour leads to an increased internal monitoring demand to control the externally triggered but internally generated conflict of the senses.…”

Section: Peter H Weiss and Othersmentioning

confidence: 62%

“…Responses and reaction times (RT) were recorded with an optic fibre tapping apparatus. Functional MR images were acquired on a Siemens Vision ® 1.5T scanner using standard EPI imaging procedures and statistical analysis (see Fink et al, 2000). The significance level was set at p = 0.001, uncorrected, for height, with an extent threshold of p = 0.05.…”

Section: Introductionmentioning

confidence: 99%

Associating Colours with People: A Case of Chromatic-Lexical Synaesthesia

Weiss

Shah

Toni

et al. 2001

Cortex

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“…In addition to identifying global abnormalities of hemispheric function a number of recent studies has probed the integrity of specific functional neuranotomical pathways, disclosing that schizophrenia involves selective deficits within the magnocellular (dorsal) processing stream (Butler et al, 2001;Foxe et al, 2001Foxe et al, , 2005Schechter et al, 2003;. This is potentially significant since parietal cortex is a major recipient of magnocellular input (Merigan & Maunsell, 1993;Ungerleider & Mishkin, 1982), and houses neural networks demonstrated to play a crucial role in the allocation of visuospatial attention (Corbetta et al, 2000;Coull et al, 2001;Fink et al, 2000;Foxe et. al, 1998;Karnath, 2001;Karnath et al, 2001), including those activated during line bisection tasks.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with hemispatial neglect bisect horizontal lines far rightward of veridical center (Heilman et al, 1993, Mesulam, 2000Robertson & Halligan, 1999). Converging evidence from both the laboratory and the clinic indicates that neural circuits in the right cerebral hemisphere play a dominant role in the allocation of visuospatial attention (Corbetta et al, 2000;Coull et al, 2001;Fink et al, 2000;Foxe et al, 2003;Karnath, 2001;Karnath et al, 2001). That the right hemisphere is dominant for this function is revealed in dramatic fashion by the severe deficits of attention directed into contralesional (left) space in hemineglect syndrome (Cappa et al, 1991;Kerkhoff, 2001;Mesulam, 1982;2000;Na et al, 2000;Vallar & Perani, 1987).…”

Section: Visuospatial Neglect and Pseudoneglectmentioning

confidence: 99%

Hemispheric asymmetry and callosal integration of visuospatial attention in schizophrenia: A tachistoscopic line bisection study

McCourt¹,

Shpaner²,

Javitt³

et al. 2008

Schizophrenia Research

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Background-A hallmark of visuospatial neglect syndrome is that patients with lesions to right parietal cortex misbisect horizontal lines far rightward of veridical center. Neurologically normal subjects misbisect lines with a systematic leftward bias (pseudoneglect). Both phenomena, as well as neuroimaging studies, disclose a predominant right hemisphere control of spatial attention. Numerous studies of patients with schizophrenia have implicated global deficits of either right or left hemisphere function, as well as compromised integrity of the corpus callosum.Methods-To better understand the functional implications of schizophrenia we utilized a forcedchoice tachistoscopic line bisection task to probe the status of right hemisphere control of spatial attention, and compared left-versus right-hand unimanual responses to index the degree of callosal transfer of visuospatial information in both patient and control groups.Results-In contrast to the significant leftward bisection errors of control subjects, patients exhibit no significant leftward error. Whereas control subjects evince a significant correlation between leftand right-hand bisection errors, patients lack a significant intermanual correlation.Conclusions-The lack of significant leftward bisection error of patients implies a deficit of right hemisphere function. The lack of a significant correlation between left-and right-hand bisection errors in patients implies a loss of callosal integrity.

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Line bisection judgments implicate right parietal cortex and cerebellum as assessed by fMRI

Abstract: The right hemispheric dominance observed in inferior parietal cortex is consistent with the results of lesion studies. Right superior parietal cortex, vermis, and left cerebellar hemisphere have not been implicated in neglect, but all appear to play a cognitive role in the Landmark task.

Cited by 360 publications

References 19 publications

Atypical Hemispheric Dominance for Attention: Functional MRI Topography

Atypical Hemispheric Dominance for Attention: Functional MRI Topography

Associating Colours with People: A Case of Chromatic-Lexical Synaesthesia

Hemispheric asymmetry and callosal integration of visuospatial attention in schizophrenia: A tachistoscopic line bisection study

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