Line differences in resistance to<i>salmonella enteritidis</i>pt4 infection

Protais, J.; Colin, P.; Beaumont, Catherine; Guillot, J.F.; Lantier, Frédéric; Pardon, Pierre; Bennejean, G.

doi:10.1080/00071669608417864

Cited by 51 publications

(44 citation statements)

References 22 publications

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“…Indeed, Protais et al [9] observed large differences when comparing poultry lines inoculated at the same time and with the same dose of inoculation. The model derived by Prévost et al [7] may be used for such data: since each line was reared separately, it was possible to process one subpopulation at a time.…”

Section: Discussionmentioning

confidence: 99%

“…This rate is partially under genetic control. Such a result could be expected from the large difference in kinetics of bacterial clearance between poultry lines [9]. The L2 egg-type line, in particular, was found to be susceptible to the Salmonella carrier-state, whether in the digestive tractus, the systemic organs or the ovaries.…”

Section: Introductionmentioning

confidence: 94%

“…Model parameters for the base population were fitted using data on the percentage of contaminated animals at various intervals, from 0 to 6 weeks post inoculation) of an egg-type poultry line called L2 [9]. Sixteen hens were inoculated at the peak of lay, per os in the crop with 10 9 cfu/mL of Salmonella enteritidis PT4 (SE) and contamination of the spleen, liver, caeca, oviduct, ovaries, and eggs assessed 1, 2, 4, and 6 weeks post inoculation [9].…”

Section: Estimation Of Parameters and Data Usedmentioning

confidence: 99%

“…Sixteen hens were inoculated at the peak of lay, per os in the crop with 10 9 cfu/mL of Salmonella enteritidis PT4 (SE) and contamination of the spleen, liver, caeca, oviduct, ovaries, and eggs assessed 1, 2, 4, and 6 weeks post inoculation [9]. The effect of selection was investigated using the results of an experiment for divergent selection achieved in the L2 line that we just modelized.…”

Section: Estimation Of Parameters and Data Usedmentioning

confidence: 99%

“…In each line and at each generation, chickens were produced in two hatches issued from the same parents. Since the Salmonella carrier-state may only be assessed on necropsied animals, half of the animals were kept to produce the breeders of the next generation while the others were orally contaminated as described in Protais et al [9] and bacteria were searched in their caeca, spleen, liver, and ovaries four weeks later. Selection was on a trait coded "1" if the caeca, spleen, or liver was found positive and "0" in the other cases, i.e., the presence of the bacteria in at least one of these three organs versus the absence of bacteria in any of them.…”

Section: Estimation Of Parameters and Data Usedmentioning

confidence: 99%

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Effect of genetic resistance of the hen toSalmonellacarrier-state on incidence of bacterial contamination: synergy with vaccination

Prevost

Magal

Protais³

et al. 2008

Vet. Res.

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-Salmonella is one of the major sources of toxi-infections in humans. The association between egg consumption and Salmonella outbreaks is a serious economic and public health problem. To control the incidence of Salmonella in poultry flocks, many prophylactic means have been developed but none allows a total reduction of the risk. In a previous study, we derived mathematical models for Salmonella transmission and used them to appreciate the most important factors of variation of egg contamination rate and thus of risk of human contamination. Thanks to recent data of a selection experiment for increased or decreased rate of carrier-state (also called divergent selection), we showed that mixing, in an equal proportion, animals issued from a line selected for a lower (denoted Sal-) or higher propensity to carry Salmonella (denoted Sal+) results in a reduction by half of the maximal percentage of contaminated animals but does not accelerate the extinction of the disease. Vaccination and selection should be synergic, since a former contamination reduces the maximal prevalence by 45 and 71%, respectively, in Sal+ or Sal-flocks respectively. These results show the interest in the introduction, even at a rather moderate percentage, of animals selected for a reduced rate of Salmonella carrier-state within commercial flocks. This could be achieved by using one or more selected lines in commercial crosses. These results must be confirmed experimentally while the mathematical model could be extended with minor modifications to other animal species or pathogenic species. Salmonella / mathematical model / genetic / resistance / vaccination

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Estimation Of Parameters and Data Usedmentioning

confidence: 99%

Section: Estimation Of Parameters and Data Usedmentioning

confidence: 99%

Section: Estimation Of Parameters and Data Usedmentioning

confidence: 99%

See 3 more Smart Citations

Effect of genetic resistance of the hen toSalmonellacarrier-state on incidence of bacterial contamination: synergy with vaccination

Prevost

Magal

Protais³

et al. 2008

Vet. Res.

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Effect of low and high doses ofSalmonella enteritidis PT4 on experimentally infected chicks

et al. 2001

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Chicks (1-d-old, three groups, each containing 50 chicks) were inoculated with 2 x 10(2) and 2 x 10(8) CFU of Salmonella enteritidis; the third group were kept as uninoculated control. Five birds from each group were euthanized at intervals from 6 h to 4 weeks post-inoculation (pi). In the low-dose group S. enteritidis was isolated from 60% cecal samples at 18 h pi, and from 20% of livers at 3 d pi. Individual variation in the frequency of S. enteritidis recovery was observed in this group. The clearance of salmonella from the organs was faster in the low-dose group, and salmonella was not isolated from the liver and cecum at 21 and at 27 d pi, respectively. However, in the high-dose group, S. enteritidis was isolated from all ceca and 80% of liver 6 h pi, and salmonella was detected in the cecum and liver throughout the experiment. Serous typhlitis and unabsorbed yolk sac were the most prevalent lesions in both groups. Granulomatous nodules in the cecum were found occasionally in some cases in both inoculated groups, which can play a role as reservoirs in carrier chicks.

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New QTL for resistance to Salmonella carrier-state identified on fowl microchromosomes

Calenge

Vignal²,

Demars³

et al. 2011

Mol Genet Genomics

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Chicken's ability to carry Salmonella without displaying disease symptoms leads to an invisible propagation of Salmonella in poultry stocks. Using chicken lines more resistant to carrier state could improve both animal health and food safety. Previous studies identified several QTL for resistance to carrier state. To improve genome coverage and QTL detection power we produced a new set of 480 informative SNP markers and genotyped a larger number of animals. Ten additional microchromosomes could be covered when compared with previous studies. These new data led to the identification of 18 QTL significant at the chromosome-wide level. The only QTL significant at the genome-wide level were identified on microchromosomes 14 and 22 and have never been identified previously. Using a higher number of animals improved the power and the precision of QTL detection. Some of the QTL newly identified are located close to candidate genes or microsatellite markers previously identified for their involvement in the genetic control of resistance to Salmonella, which confirms their interest for selection purposes.

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Line differences in resistance tosalmonella enteritidispt4 infection

Cited by 51 publications

References 22 publications

Effect of genetic resistance of the hen toSalmonellacarrier-state on incidence of bacterial contamination: synergy with vaccination

Effect of genetic resistance of the hen toSalmonellacarrier-state on incidence of bacterial contamination: synergy with vaccination

Effect of low and high doses ofSalmonella enteritidis PT4 on experimentally infected chicks

New QTL for resistance to Salmonella carrier-state identified on fowl microchromosomes

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