Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, <i>in‐vivo</i> diagnosis of herpes infection of the skin

Lacarrubba, Francesco; Verzì, Anna Elisa; Puglisi, Davide Francesco; Micali, Giuseppe

doi:10.1111/jdv.17182

Cited by 22 publications

(19 citation statements)

References 8 publications

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“…The usefulness of LC-OCT has been reported in a variety of skin disorders such as infectious diseases, autoimmune bullous diseases, skin tumours and other conditions. 1,3,[5][6][7][8][9][10][11][12][13][14] The aim of our study was to evaluate LC-OCT imaging in some common inflammatory skin disorders, that is plaque psoriasis, atopic eczema and lichen planus and to correlate the resulting features with histopathological findings.…”

Section: Introductionmentioning

confidence: 99%

Line‐field confocal optical coherence tomography of psoriasis, eczema and lichen planus: a case series with histopathological correlation

Verzì

Broggi

Micali

et al. 2022

Acad Dermatol Venereol

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Background Line-field confocal optical coherence tomography (LC-OCT) is a novel, non-invasive technique that provides in vivo, high-resolution images in both vertical and horizontal sections.Objectives The aim of the study was to evaluate LC-OCT imaging in some inflammatory disorders and to correlate the resulting features with histopathology.Methods The retrospective study included patients with histopathological confirmed diagnosis of plaque psoriasis, atopic eczema and lichen planus, who were imaged with LC-OCT before the biopsy. LC-OCT was performed with the commercially available LC-OCT device.Results A total of 15 adult patients with histopathologically proven plaque psoriasis (N: 5), atopic eczema (N: 5) and lichen planus (N: 5) were included. In all cases, LC-OCT allowed the in vivo recognition of the main microscopic features of the examined inflammatory skin disease, with a strong correlation with histopathology.Conclusions Although future studies on larger series of patients are necessary, LC-OCT, based on these preliminary findings, may represent a promising tool in inflammatory skin disorders with potential applications including enhanced diagnosis, biopsy guidance, follow-up and treatment monitoring.

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Section: Introductionmentioning

confidence: 99%

Line‐field confocal optical coherence tomography of psoriasis, eczema and lichen planus: a case series with histopathological correlation

Verzì

Broggi

Micali

et al. 2022

Acad Dermatol Venereol

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“…Recent studies have shown that LC-OCT can clearly identify different skin structures including single epidermal cells and the DEJ in healthy skin. 27 Moreover, it can reveal the cleavage level in autoimmune bullous disorders, 28 and it could aid the diagnosis of basal cell carcinoma (BCC), 29 melanocytic tumours, 30,31 vascular tumours, 32 skin infections, 33,34 genetic disorders 35,36 and diseases characterized by altered keratinization. 37 LC-OCT seems to be promising for the identification of keratinocyte tumours and their invasiveness, 12 but no large studies are yet available for AK and SCC.…”

Section: Introductionmentioning

confidence: 99%

Line‐field confocal optical coherence tomography for actinic keratosis and squamous cell carcinoma: a descriptive study

Cinotti

Tognetti

Cartocci

et al. 2021

Clin Experimental Derm

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Background. Early and accurate diagnosis of cutaneous squamous cell carcinomas (SCCs) and actinic keratoses (AK) is fundamental to reduce their associated morbidity and to select the correct treatment. Line-field confocal optical coherence tomography (LC-OCT) is a new imaging device that can characterize healthy skin and basal cell carcinoma, but no large studies on keratinocyte cell tumours have yet been published. Aim. To identify and describe LC-OCT criteria associated with SCC and AK, and to compare LC-OCT findings in these tumours. Methods. A retrospective observational multicentre study was conducted. Lesions were imaged with the LC-OCT device before surgery and examined histologically. LC-OCT criteria for AK/SCC were identified and their presence was evaluated in all study lesions. Univariate and multivariate analyses were performed to compare AK and SCCs, and to investigate differences between in situ and invasive tumours. Results. In total, 158 patients with 50 AK and 108 SCCs (62 in situ and 46 invasive) were included. Cytological and architectural alterations were found in most lesions, and differences were found between AK and SCCs. Although the visualization of the dermoepidermal junction (DEJ) was often hampered by hyperkeratosis and acanthosis, an outlined DEJ without broad strands was observed in almost all AK and almost all in situ SCCs, but in only three invasive SCCs (P < 0.001) when the DEJ was detectable. Conclusion. Our results suggest that LC-OCT can help clinicians in the identification of AK and SCC and their differentiation, providing a real-time and noninvasive examination. Further studies are needed to confirm our data.

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“…The interest of using LC-OCT in the diagnosis of skin disorders is growing. Reported applications include benign dermal melanocytic proliferations [ 4 ], skin tumors such as actinic keratoses, squamous and basal cell carcinoma (BCC) [ 1 , 5 , 6 , 7 , 8 ], sebaceous hyperplasia [ 9 ], xanthogranuloma [ 10 ], autoimmune bullous diseases [ 11 ], herpes infection [ 12 ], scabies [ 13 ], aquagenic keratoderma [ 14 ], Kaposi’s sarcoma [ 15 ], and circumscribed palmar hypokeratosis [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Line-Field Confocal Optical Coherence Tomography May Enhance Monitoring of Superficial Basal Cell Carcinoma Treated with Imiquimod 5% Cream: A Pilot Study

Verzì

Micali

Lacarrubba

2021

Cancers

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Line-field confocal optical coherence tomography (LC-OCT) is a novel, non-invasive technique for real-time skin imaging. Imiquimod (IQ) 5% cream is an immune response modifier currently approved for the treatment of small, superficial basal cell carcinoma (BCC). The aim of this study was to investigate if LC-OCT may be useful to enhance the treatment monitoring of BCC. Twenty superficial BCCs from 12 patients were treated with IQ 5% cream once daily, five days a week, for six weeks. Clinical and LC-OCT evaluations were performed at baseline and 4 weeks after the end of treatment. At the end of the study, 13 lesions showed a complete clinical and LC-OCT response, 4 lesions a partial clinical and LC-OCT response, and 3 lesions a complete clinical response but residual tumoral signs at LC-OCT. Our pilot study suggests that LC-OCT may represent a promising tool able to enhance the evaluation of the treatment response of BCCs to non-invasive treatments. In our case series, its use highlighted, through a detailed, fast, and complete examination of the treated area, three cases of residual BCC that otherwise would have gone undetected at clinical examination. Future studies on larger series of patients treated with different modalities and with a longer follow-up are advisable.

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Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, in‐vivo diagnosis of herpes infection of the skin

Cited by 22 publications

References 8 publications

Line‐field confocal optical coherence tomography of psoriasis, eczema and lichen planus: a case series with histopathological correlation

Line‐field confocal optical coherence tomography of psoriasis, eczema and lichen planus: a case series with histopathological correlation

Line‐field confocal optical coherence tomography for actinic keratosis and squamous cell carcinoma: a descriptive study

Line-Field Confocal Optical Coherence Tomography May Enhance Monitoring of Superficial Basal Cell Carcinoma Treated with Imiquimod 5% Cream: A Pilot Study

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