We continue our study of renormalization group (RG) flows on Wilson loop defects in ABJM theory, which we have initiated in arXiv:2211.16501. We generalize that analysis by including non-supersymmetric fixed points and RG trajectories. To this end, we first determine the “ordinary”, non-supersymmetric Wilson loops, which turn out to be two and to include an R-symmetry preserving coupling to the scalar fields of the theory, contrary to their four-dimensional counterpart defined solely in terms of the gauge field holonomy. We then deform these operators by turning on bosonic and/or fermionic couplings, which trigger an elaborate, multi-dimensional network of possible RG trajectories connecting a large spectrum of fixed points classified in terms of the amount (possibly zero) of supersymmetry and R-symmetry preserved. The β-functions are computed to leading order in the ABJM coupling but exactly in the deformation parameters, using an auxiliary one-dimensional theory on the defect and a dimensional regularization scheme. A striking result is the different behavior of the two ordinary Wilson loops, of which one turns out to be a UV unstable point while the other is IR stable. The same is true for the two 1/2 BPS Wilson loops. We interpret our results from a defect CFT (dCFT) point of view, computing the anomalous dimensions of the operators associated to the deformations and establishing appropriate g-theorems. In particular, the fermionic unstable fixed point is associated to a dCFT which is not reflection positive.