Line Probe Assay as a Rapid Tool for Detection of MDRTB

Abstract

This work was carried out in collaboration between all authors. Author RR designed the study, performed the data acquisition, data analysis, and statistical analysis, wrote the protocol, and wrote the first draft of the manuscript and manuscript review. Author GSVK managed data analysis, statistical analysis, and manuscript review, analyses of study, manuscript editing and review. Authors VJ and RR managed the analyses of the study, manuscript editing and review. All authors read and approved the final manuscript.

A Benchtop Automated Sputum-to-Genotype System Using a Lab-on-a-Film Assembly for Detection of Multidrug-Resistant Mycobacterium tuberculosis

“…This test, however, is limited to detection of MTB and RIF resistance, and it uses a method of “sloppy molecular beacons”, which does not report specific mutations. , Another XDR-TB test is in development, which includes markers for INH but does not include markers for RIF; thus, it is intended as a reflex test to their MTB/RIF test. , Ao et al also describes an MTB/RIF test, which reports mutations, but it does not include INH resistance . There are a number of molecular MDR-TB tests that are high complexity (do not include integrated sample preparation) available from Hain (LPA and Fluorotype), Capital Bio, InSilixa, Veredus, Abbott, and Roche . The number of MDR-TB tests that include integrated sample preparation are more limited.…”