Lineage mapping and characterization of the native progenitor population in cellular allograft

A Retrospective Clinical Comparison of Two Allogeneic Bone Matrices Containing Viable Osteogenic Cells in Patients Undergoing Foot and/or Ankle Arthrodesis

“…Since there were no significant difference in fusion rates for patients with and without Charcot neuropathy, CBA may help overcome this challenging environment for bone healing. In addition, an attempted revision has been previously identified as a significant risk factor for persistent nonunion and a 77% fusion rate resulted following revisional arthrodesis of the foot and ankle [32]. Although the sample size was small, the current study demonstrated a substantially higher fusion rate, 87.5% (7/8), following revisional surgery.…”

“…CBA contains viable MSCs which are capable of proliferation and osteogenic differentiation [32] and may help overcome the cellular limitations of diabetes.…”

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“…Since their discovery in 1966, MSCs have been widely studied and have been shown to be a key component in bony healing. MSCs are able to self-renew and are multipotential with the capacity to differentiate into bone, cartilage, fat, nerve, muscle, tendon and mature stromal cell lineages, depending on both intrinsic and extrinsic cues in the local environment 2,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] (Figure 1).…”

Bone allograft with mesenchymal stem cells: A critical review of the literature

“…Since their discovery in 1966, MSCs have been widely studied and have been shown to be a key component in bony healing. MSCs are able to self-renew and are multipotential with the capacity to differentiate into bone, cartilage, fat, nerve, muscle, tendon and mature stromal cell lineages, depending on both intrinsic and extrinsic cues in the local environment 2,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] (Figure 1).…”

“…Despite these possibilities, when trabecular bone is harvested, the yield contains 65-fold more progenitor cells 23,24 . By leaving MSCs attached to the trabecular bone, there is a greater expression of osteogenic genes and increased secretion of osteogenic factors 18 . For this reason, commercially available allograft/ MSC products are generated by harvesting cells from trabecular bone and leaving the MSCs adherent to the natural trabecular tissue.…”