Linear dicarboxylato and tridentate chelating ligands coordinated Cu(II) complexes: Syntheses, crystal structures, protein binding and cytotoxicity studies

Two new Cu(II) complexes [Cu 2 (L) 2 (mb)](ClO 4 )Á0.5H 2 O (1) and [Cu 4 (L) 4 (sq) (H 2 O) 2 ](ClO 4 ) 2 Á2H 2 O (2) (HL = 2-[(2-morpholine-4-yl-ethylimino)-methyl]phenol); mb = 4-methyl benzoate; sq 2À = C 4 O 4 2À squarate dianion) have been synthesized and characterized by single crystal X-ray analysis, electrospray ionization mass spectrometry, and infrared spectroscopic technique. The structural determination showed the Schiff base acting as tridentate ligand coordinating the copper(II) atoms by the phenoxo, imino and morpholine nitrogen donors to give comparable Cu(L) entities in both complexes 1 and 2. Complex 1 is a dinuclear cationic species built by a 4-methylbenzoate anion coordinating two Cu(L) moieties. The two Cu(II) centers are chemically equivalent exhibiting a distorted square pyramidal geometry. Complex 2 is tetranuclearand it is formed by a centrosymmetric squarate core connected to four Cu(L) complex units to give a cationic complex counterbalanced by perchlorate anions. Of the two independent Cu(II) atoms, Cu1 exhibits a square pyramidal coordination sphere, whereas Cu2 is better described as square planar.The crystal packing of complex 2 shows a polymeric arrangement through H-bonding. Magnetic measurements show antiferromagnetic coupling in both the complexes. The interaction of complexes with hen egg lysozyme has been investigated by using UV-vis absorption and 2D/3D fluorescence spectroscopic techniques and the calculated values of binding constants, K bin , are (5.9 ± 0.11) Â 10 4 , (17.39 ± 0.04) Â 10 4 , and (10.1 ± 0.07) Â 10 4 M À1 for HL, 1, and 2, respectively.

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Carboxylato‐ and squarato‐bridged dinuclear/tetranuclear Cu(II) complexes: Synthesis, magnetic property, and protein binding studies

Patra

Carrella

Saren

et al. 2022

Applied Organom Chemis

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Tris chelated meridional isomers of Co(III) complexes: Synthesis, crystal structure, protein binding, cytotoxicity studies and DFT/TDDFT calculation

Saren

Das

Paul

et al. 2023

Inorganica Chimica Acta

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Tryptophan moiety based tetranuclear Ni(II) complex: synthesis, crystal structure and fluorescence sensing

Mahish,

Zangrando,

Vojtíšek

et al. 2024

Inorganica Chimica Acta

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Linear dicarboxylato and tridentate chelating ligands coordinated Cu(II) complexes: Syntheses, crystal structures, protein binding and cytotoxicity studies

Cited by 6 publications

References 39 publications

Carboxylato‐ and squarato‐bridged dinuclear/tetranuclear Cu(II) complexes: Synthesis, magnetic property, and protein binding studies

Carboxylato‐ and squarato‐bridged dinuclear/tetranuclear Cu(II) complexes: Synthesis, magnetic property, and protein binding studies

Tris chelated meridional isomers of Co(III) complexes: Synthesis, crystal structure, protein binding, cytotoxicity studies and DFT/TDDFT calculation

Tryptophan moiety based tetranuclear Ni(II) complex: synthesis, crystal structure and fluorescence sensing

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