In Physics and in Mathematics Z n 2 -gradings, n ≥ 2, appear in various fields. The corresponding sign rule is determined by the 'scalar product' of the involved Z n 2 -degrees. The Z n 2 -Supergeometry exhibits challenging differences with the classical one: nonzero degree even coordinates are not nilpotent, and even (resp., odd) coordinates do not necessarily commute (resp., anticommute) pairwise. In this article we develop the foundations of the theory: we define Z n 2 -supermanifolds and provide examples in the ringed space and coordinate settings. We thus show that formal series are the appropriate substitute for nilpotency. Moreover, the class of Z • 2 -supermanifolds is closed with respect to the tangent and cotangent functors. We explain that any n-fold vector bundle has a canonical 'superization' to a Z n 2 -supermanifold and prove that the fundamental theorem describing supermorphisms in terms of coordinates can be extended to the Z n 2 -context.