Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury

Vimal, V.; Devaki, Thiruvengadam

doi:10.1016/j.biopha.2003.12.007

Cited by 49 publications

(26 citation statements)

References 35 publications

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“…ISO-administration produces cytotoxic free radicals, causes myocardial cell necrosis. Cytotoxic effects of reactive oxygen species are related in their reaction with membrane lipids [37].…”

Section: Discussionmentioning

confidence: 99%

Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats

Rajadurai

Prince

2006

J. Biochem. Mol. Toxicol.

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This study was designed to evaluate the preventive effect of naringin in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with naringin (10, 20, and 40 mg/kg body weight) orally for a period of 56 days. After the treatment period, ISO (85 mg/kg body weight) was administered subcutaneously to rats at an interval of 24 h for 2 days. There was a significant increase in the levels of total, ester, and free cholesterol, triglycerides (TG), and free fatty acids (FFA) in serum and heart and decrease in heart phospholipids (PL) in ISO-induced rats. Altered levels of lipoproteins and activities of 3-hydroxy-3-methylglutaryl-Coenzyme reductase A in liver and heart, lecithin cholesterol acyl transferase and lipoprotein lipase in plasma were also observed in ISO-induced rats. Pretreatment with naringin (10, 20, and 40 mg/kg) for a period of 56 days significantly decreased the levels of total, ester, and free cholesterol, TG, FFA in serum and heart and increased PL in heart. It also minimized the alterations in serum lipoproteins and lipid metabolic enzymes in ISO-induced rats. Thus, naringin has a lipid-lowering effect in ISO-induced MI rats.

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“…ISO-administration produces cytotoxic free radicals, causes myocardial cell necrosis. Cytotoxic effects of reactive oxygen species are related in their reaction with membrane lipids [37].…”

Section: Discussionmentioning

confidence: 99%

Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats

Rajadurai

Prince

2006

J. Biochem. Mol. Toxicol.

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“…Literature data show that administration of isoproterenol subcutaneously as a result has a significant increase in serum markers of myocardial injury, such as SGOT, SGPT, CPK, CK-MB, LDH and troponin [10,21,22]. It is reported that plasma levels of these markers are directly proportional to the degree of necrotic lesions present in the myocardium and thus are markers of myocardial damage [10.23].…”

Section: Discussionmentioning

confidence: 99%

Modelo experimental de infarto do miocárdio induzido por isoproterenol em ratos

Filho¹,

Ferreira²,

Sousa³

et al. 2011

Rev Bras Cir Cardiovasc

103

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Objective: To evaluate and validate, in our laboratory, the essay of myocardial infarction induced by isoproterenol in rats by means of analysis of hematological, biochemical, oxidative stress markers and histopathological parameters.Methods: Thirty young, male, Wistar rats (145 to 230 g) were randomly allocated in two groups: Sham group, which underwent a virtual myocardial infarction induction, and the Infarction group, which underwent a myocardial infarction induction with isoproterenol. The administrations for the infarction induction were performed during two consecutive days and a 24-hour interval between them. Twenty-four hours after the last administration, rats from both groups were anesthetized and sacrificed for blood sample collection to evaluate complete blood count (CBC) and biochemical parameters (SGOT, SGPT, troponin I, urea and creatinin), obtain myocardial fragments for oxidative stress markers analyses (catalase activity and glutathione concentrations) as well as histopathological examinations.Results: There were no death cases in the Sham group, while the mortality rate in the Infarction group was 25%. Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, SGOT, troponin I and urea concentrations, reduced catalase enzyme activity and glutathione concentrations in the myocardium and let to histopathological concentrations as well. It did not exert alterations in terms of hemoglobin, SGPT and creatinin concentrations.Conclusion: The isoproterenol-induced myocardial infarction essay in rats was adequately reproduced in our laboratory, causing alterations in hematological, biochemical, oxidative stress markers and histopathological parameters. Rev Bras Cir Cardiovasc 2011;26(3):469-76 In the literature, there is a series of studies using this model, evaluating the effect of different substances on biochemical, oxidative stress markers and histopathological damage resulting from myocardial in rats [8,9]. DescriptorsThis study aims to evaluate and validate, in our environment, the model of isoproterenol inducedmyocardial infarction in rats, given the scarcity of scientific publications using this model in our country METHODS This study, whose data are from a Master

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“…(Rutaceae), used for the treatment of a variety of disorders (Nadkarni, 1986). The plant is reported to have multiple therapeutic properties such as anti-inflammatory, antipyretic and analgesic (Arul et al, 2005;Shankarananth et al, 2007), anti diabetic (Kamalakkannan et al, 2003;Arumugam et al, 2008;Kesari et al, 2006), anti diarrheal (Shoba and Thomas, 2001), anti hyperlipidemic (Vijaya et al, 2009), antifungal (Rana et al, 1997), antimicrobial, antibacterial and anti parasitic (Ulahannan et al, 2008), anti cancer (Gangadevi and Muthumary, 2008), anti malaria (Elango et al, 2009), hepatoproctective (Singh and Rao, 2008) and cardioprotective (Vimal and Devaki, 2004) potentials.…”

Section: Introductionmentioning

confidence: 97%

Immunomodulatory activity of methanolic fruit extract of Aegle marmelos in experimental animals

Patel¹,

Asdaq²

2010

Saudi Pharmaceutical Journal

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Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury

Cited by 49 publications

References 35 publications

Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats

Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats

Modelo experimental de infarto do miocárdio induzido por isoproterenol em ratos

Immunomodulatory activity of methanolic fruit extract of Aegle marmelos in experimental animals

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