Linear growth in response to growth hormone treatment in children with short stature associated with intrauterine growth retardation: The National Cooperative Growth Study experience

Lessons from the national cooperative growth study

“…For example, an initial review of the benefit of GH in cystic fibrosis (9) in patients enrolled in the NCGS led to a formal randomized study (10,11), which has confirmed improved growth, decreased protein catabolism and improved clinical status when GH is used in this population. Similar data reviews have suggested benefit in a variety of conditions, including Noonan syndrome (12), Aarskog syndrome (13), intrauterine growth retardation (14) and several other syndromes associated with short stature (15).…”

Diagnosis and management of Silver–Russell syndrome: first international consensus statement

“…Overall, clinical trials of GH treatment in patients with SGA (in which patients with SRS were included) demonstrated a satisfactory growth response and an increase in predicted adult height of 7-11 cm at pharmacological doses of GH [97][98][99][100]102 . However, the response in patients with SRS was not investigated until a Dutch longitudinal study analysed the response to GH in 62 children with a clinical diagnosis of SRS using the NH-CSS compared with 227 short, non-syndromic children born SGA.…”

“…Finally, young children with SRS who are malnourished might not heal well following surgery 96 . [97][98][99][100][101] . The results of these clinical trials, therefore, validate the use of GH for patients with SRS.…”

Tratamento com hormônio de crescimento em crianças com baixa estatura nascidas pequenas para a idade gestacional

“…(27)(28)(29)(30)(31)(32)(33). O efeito dose-dependente nos primeiros anos de tratamento se tornou evidente (29,30,34,35).…”