Linear IgA bullous dermatosis in association with multiple sclerosis

Vancomycin‐associated linear IgA bullous dermatosis mimicking toxic epidermal necrolysis

“…Although vancomycin is the most frequently involved agent in drug‐induced LABD, this form of presentation has been rarely reported 1–4 . A similar case was described with phenytoin, 5 and there are a few reports of idiopathic LABD mimicking Stevens–Johnson syndrome 6 and TEN 7,8 . When the later is suspected the microscopic examination of the frozen section of a blister roof is helpful to confirm full‐thickness epidermal necrosis.…”

Linear IgA bullous dermatosis

“… 12 There seems to be a real association between ulcerative colitis (UC) and LABD, although the reason for this association is unknown; one study found UC to be present in five out of 70 (7.1%) LABD patients, a prevalence much higher than expected; spontaneous remission of LABD coincident with a total colectomy for UC has also been described. 64,65 Other disease associations include multiple sclerosis, 66 dermatomyositis, 67 Crohn’s disease, 68 hydatidiform mole, 69 and rheumatoid arthritis. 70 LABD developing after a cardiac transplant while the patient was on high‐dose immunosuppressive therapy has also been described.…”

The Role of the Isomorphic Phenomenon in Distinguishing Drug-Induced Linear IgA Bullous Dermatosis

“…Commonly acquired cases are drug-induced or secondary to malignancies, such as chronic lymphocytic lymphoma, multiple myeloma or Hodgkin's lymphoma [1,4]. Other autoimmune diseases have been reported to be associated with LABD, including Crohn's disease, ulcerative colitis, systemic lupus erythematous, and multiple sclerosis [5]. Drug-induced LABD commences shortly after initiation of medications, vancomycin being the most common culprit, with lesions erupting after 1-13 days [1,6].…”